Palmatine Attenuates Osteoclast Differentiation and Function through Inhibition of Receptor Activator of Nuclear Factor-.KAPPA.B Ligand Expression in Osteoblast Cells

Lee, Jiwon; Mase, Nobuyuki; Yonezawa, Takayuki; Seo, Hwajeong; Jeon, Won Bae; Yoon, Byung; Nagai, Kazuo; Woo, Je‐Tae

doi:10.1248/bpb.33.1733

Cited by 26 publications

(20 citation statements)

References 47 publications

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“…These compounds can be divided into 6 categories, including flavonoids: icariin (Figure 1) [23–26], genistein (Figure 2) [29], daidzein (Figure 2) [31, 32], kaempferol (Figure 11) [72], quercetin (Figure 11) [73, 74], naringin (Figure 8) [75–77], hesperidin (Figure 11) [78], linarin (Figure 11) [79], bavachalcone (Figure 3) [36], rutin (Figure 11) [80], (+)-catechin (Figure 11) [81], nobiletin (Figure 11) [82], luteolin (Figure 11) [83], baicalein (Figure 11) [84], baicalin (Figure 1) [85], xanthohumol (Figure 11) [86]; coumarins: psoralen (Figure 3) [35], osthole (Figure 11) [87]; lignans: honokiol (Figure 11) [88, 89], isotaxiresinol (Figure 11) [90], magnolol (Figure 11) [91]; polyphenol: resveratrol (Figure 11) [92–95], curcumin (Figure 11) [96–98], tea polyphenols (including epigallocatechin-3-gallate, epigallocatechin, epi-catechin, epicatechin-3-gallate, Figure 11) [99, 100]; anthraquinones: rubiadin (Figure 10), 2-hydroxy-1-methoxy-anthraquinone (Figure 10), 1,3,8-trihydroxy-2-methoxy-anthraquinone (Figure 10) [71]; alkaloids: harmine (Figure 11) [101], coptisine (Figure 11) [102], palmatine (Figure 11) [103], berberine (Figure 11) [104, 105]; and other compounds: curculigoside (Figure 11) [106, 107], asperosaponin VI (Figure 11) [108], limonoid 7-oxo-deacetoxygeduni...…”

Section: Resultsmentioning

confidence: 99%

Potential Antiosteoporotic Agents from Plants: A Comprehensive Review

Jia

Nie

Cao

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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Osteoporosis is a major health hazard and is a disease of old age; it is a silent epidemic affecting more than 200 million people worldwide in recent years. Based on a large number of chemical and pharmacological research many plants and their compounds have been shown to possess antiosteoporosis activity. This paper reviews the medicinal plants displaying antiosteoporosis properties including their origin, active constituents, and pharmacological data. The plants reported here are the ones which are commonly used in traditional medical systems and have demonstrated clinical effectiveness against osteoporosis. Although many plants have the potential to prevent and treat osteoporosis, so far, only a fraction of these plants have been thoroughly investigated for their physiological and pharmacological properties including their mechanism of action. An attempt should be made to highlight plant species with possible antiosteoporosis properties and they should be investigated further to help with future drug development for treating this disease.

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Section: Resultsmentioning

confidence: 99%

Potential Antiosteoporotic Agents from Plants: A Comprehensive Review

Jia

Nie

Cao

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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“…Recently, berberine and coptisine have been reported to inhibit the receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast differentiation from osteoclast precursors, the survival of mature osteoclasts, and ovariectomy-stimulated bone resorption in rats (Li et al 1999; Hu et al 2008; Lee et al 2008; Lee et al 2012). In contrast, the inhibitory effect of palmatine on osteoclast differentiation and function is markedly weaker than that of berberine (Hu et al 2008; Lee et al 2010, 2012). Since both berberine and coptisine affected leaf development, the methylene dioxy substituent at positions 2 and 3 on the benzo ring might be responsible for determining their targets, although their targets might be different from that in RANKL-induced osteoclast differentiation in rats.…”

Section: Discussionmentioning

confidence: 99%

Berberine enhances defects in the establishment of leaf polarity in asymmetric leaves1 and asymmetric leaves2 of Arabidopsis thaliana

et al. 2012

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Leaves develop as flat lateral organs from the indeterminate shoot apical meristem. The establishment of polarity along three-dimensional axes, proximal–distal, medial–lateral, and adaxial–abaxial axes, is crucial for the growth of normal leaves. The mutations of ASYMMETRIC LEAVES1 (AS1) and AS2 of Arabidopsis thaliana cause defects in repression of the indeterminate state and the establishment of axis formation in leaves. Although many mutations have been identified that enhance the adaxial–abaxial polarity defects of as1 and as2 mutants, the roles of the causative genes in leaf development are still unknown. In this study, we found that wild-type plants treated with berberine produced pointed leaves, which are often observed in the single mutants that enhance phenotypes of as1 and as2 mutants. The berberine-treated as1 and as2 mutants formed abaxialized filamentous leaves. Berberine, an isoquinoline alkaloid compound naturally produced in various plant sources, has a growth inhibitory effect on plants that do not produce berberine. We further showed that transcript levels of meristem-specific class 1 KNOX homeobox genes and abaxial determinant genes were increased in berberine-treated as1 and as2. Berberine treated plants carrying double mutations of AS2 and the large subunit ribosomal protein gene RPL5B showed more severe defects in polarity than did the as2 single mutant plants. We suggest that berberine inhibits (a) factor(s) that might be required for leaf adaxial cell differentiation through a pathway independent of AS1 and AS2. Multiple pathways might play important roles in the formation of flat symmetric leaves.Electronic supplementary materialThe online version of this article (doi:10.1007/s11103-012-9929-7) contains supplementary material, which is available to authorized users.

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“…Palmatine (C 21 H 25 NO 4 , Pal), an active naturally occurring isoquinoline alkaloids, is another important bioactive component derived from C . chinensis besides berberine [9, 10]. Modern pharmacological investigations show that Pal exerts a broad variety of potentially useful pharmacological and therapeutic properties ranging from antibacterial to anticancer [11–18].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Helicobacter pylori and Its Associated Urease by Palmatine: Investigation on the Potential Mechanism

Zhou

Tan

et al. 2017

PLoS ONE

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In this paper, we evaluated the anti-Helicobacter pylori activity and the possible inhibitory effect on its associated urease by Palmatine (Pal) from Coptis chinensis, and explored the potential underlying mechanism. Results indicated that Pal exerted inhibitory effect on four tested H. pylori strains (ATCC 43504, NCTC 26695, SS1 and ICDC 111001) by the agar dilution test with minimum inhibitory concentration (MIC) values ranging from 100 to 200 μg/mL under neutral environment (pH 7.4), and from 75 to 100 μg/mL under acidic conditions (pH 5.3), respectively. Pal was observed to significantly inhibit both H. pylori urease (HPU) and jack bean urease (JBU) in a dose-dependent manner, with IC50 values of 0.53 ± 0.01 mM and 0.03 ± 0.00 mM, respectively, as compared with acetohydroxamic acid, a well-known urease inhibitor (0.07 ± 0.01 mM for HPU and 0.02 ± 0.00 mM for JBU, respectively). Kinetic analyses showed that the type of urease inhibition by Pal was noncompetitive for both HPU and JBU. Higher effectiveness of thiol protectors against urease inhibition than the competitive Ni2+ binding inhibitors was observed, indicating the essential role of the active-site sulfhydryl group in the urease inhibition by Pal. DTT reactivation assay indicated that the inhibition on the two ureases was reversible, further supporting that sulfhydryl group should be obligatory for urease inhibition by Pal. Furthermore, molecular docking study indicated that Pal interacted with the important sulfhydryl groups and inhibited the active enzymatic conformation through N-H ∙ π interaction, but did not interact with the active site Ni2+. Taken together, Pal was an effective inhibitor of H. pylori and its urease targeting the sulfhydryl groups, representing a promising candidate as novel urease inhibitor. This investigation also gave additional scientific support to the use of C. chinensis to treat H. pylori-related gastrointestinal diseases in traditional Chinese medicine. Pal might be a potentially beneficial therapy for gastritis and peptic ulcers induced by H. pylori infection and other urease-related diseases.

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Palmatine Attenuates Osteoclast Differentiation and Function through Inhibition of Receptor Activator of Nuclear Factor-.KAPPA.B Ligand Expression in Osteoblast Cells

Cited by 26 publications

References 47 publications

Potential Antiosteoporotic Agents from Plants: A Comprehensive Review

Potential Antiosteoporotic Agents from Plants: A Comprehensive Review

Berberine enhances defects in the establishment of leaf polarity in asymmetric leaves1 and asymmetric leaves2 of Arabidopsis thaliana

Inhibition of Helicobacter pylori and Its Associated Urease by Palmatine: Investigation on the Potential Mechanism

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