Palmitoleic Acid Calcium Salt: A Lubricant and Bactericidal Powder from Natural Lipids

Yamamoto, Yoshiaki; Kawamura, Yuki I.; Yamazaki, Yoji; Kijima, Toshiki; Morikawa, T.; Nonomura, Yoshiaki

doi:10.5650/jos.ess14176

Cited by 23 publications

(24 citation statements)

References 29 publications

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“…The difference between the lubrications of these three Ca salts of fatty acids is caused by their crystal structures. In the cases of C18:0 and C18:1 fatty acid Ca salts, the lubricity is due to three factors 5,6,13 . The first and second factors are cleavage of the lamellar layers and disintegration of the powder aggregates.…”

Section: Lubricant Properties Of Ca Salts Of Fatty Acidsmentioning

confidence: 99%

“…Recently, the selective bactericidal ability of C16:1 fatty acid Ca salts was found for Staphylococcus aureus and Propionibacterium acnes 13 .…”

Section: Bactericidal Properties Of Ca Salts Of Fatty Acidsmentioning

confidence: 99%

“…Recently, we showed that C16:1 fatty acid Ca salt exhibits a high lubrication ability as well as selective bactericidal activity 13 . In this study, we investigated the crystal structure, lubricity, and bactericidal properties of Ca salts of C18:0, C18:1, and C18:2 fatty acids to determine the effect of the degree of unsaturation.…”

Section: Introductionmentioning

confidence: 99%

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Lubricant and Bactericidal Properties of Calcium Salts of Fatty Acids: Effect of Degree of Unsaturation

et al. 2015

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Section: Lubricant Properties Of Ca Salts Of Fatty Acidsmentioning

confidence: 99%

“…Recently, the selective bactericidal ability of C16:1 fatty acid Ca salts was found for Staphylococcus aureus and Propionibacterium acnes 13 .…”

Section: Bactericidal Properties Of Ca Salts Of Fatty Acidsmentioning

confidence: 99%

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Lubricant and Bactericidal Properties of Calcium Salts of Fatty Acids: Effect of Degree of Unsaturation

et al. 2015

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“…Palmitoleic acid has bactericidal properties toward Staphylococcus aureus, Helicobacter pylori, Streptococcus salivarius, Fusobacterium nucleatum and Neisseria gonorrhoeae (Yamamoto et al 2015). Palmitoleic acid and linoleic acid showed identical binding affinity to RRF (Table 1) although palmitoleic acid has been solely docked with Ala41 of RRF (Fig.…”

Section: Resultsmentioning

confidence: 98%

Computational approaches to the in vitro antibacterial activity of Allium hirtifolium Boiss against gentamicin-resistant Escherichia coli: focus on ribosome recycling factor

Ali

Chehri

Karimi

et al. 2017

In Silico Pharmacol.

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Persian shallot, Allium hirtifolium Boiss. (AH), is an Iranian native medicinal plant belongs to Alliaceae family. Here, we investigated in vitro antibacterial activity of hydro-alcoholic extract derived from bulbs of AH. We also employed in silico molecular docking to decipher mechanisms of its antibacterial effects. Minimum inhibitory concentrations (MIC) and minimum bactericidal concentration (MBC) against E. coli ATCC 25922 were determined. Molecular docking was performed for major phytochemicals of AH against ribosome recycling factor (RRF). E. coli ATCC 25922 was gentamicin-resistant while AH showed MIC (42 ± 18 lg/ml) and MBC (106 ± 36 lg/ml) against E. coli. In silico results reported all phytochemicals of AH shown acceptable negative binding affinity (kcal/-mol) with RRF.

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“…The 18 : 0 and 18 : 1 contents also exhibited a similar tendency. Conversely, the content of 16 : 1, which may be associated with moisturizing effects by its strong lubricity, 21) decreased in the order of C group > S group > D group. The branched-chain FA content displayed an order similar to 16 : 1 content: C group > S group > D group, and as did 16 : 0b content.…”

Section: Fig 2 Total Serum Ige Levels and Dermatitis Score For All mentioning

confidence: 95%

Influence of Hot Spring Water on Fatty Acid Composition of Skin Surface Lipids in Hairless Mouse Model of Atopic Dermatitis

Nishimura

Aoyanagi

Uchino

et al. 2016

Biological & Pharmaceutical Bulletin

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When hairless NCN24 mice with atopic dermatitis (AD) were sprayed with a petroleum-containing alkaline salt spring water rich in metaboric acid and sodium bicarbonate, AD symptoms diminished. Reversedphase HPLC with fluorescence detection (HPLC/FD) and online MS revealed that fatty acid (FA) composition of the skin surface lipids was similar to that in non-AD mice compared with that in AD mice. Strong negative correlations were noted between the levels of total serum immunoglobulin E (IgE) and palmitoleic acid and between the levels of total serum IgE and branched-hexadecanoic acid. Conversely, a strong positive correlation was noted between the levels of total serum IgE and linoleic acid. The present study demonstrates that the petroleum-containing spring water alters the FA composition of skin surface lipids in AD mice, which can be used as an index to evaluate inflammation.Key words atopic dermatitis; hot spring water; fatty acid; NCN24 mouse; skin surface lipid; fluorescence detection Atopic dermatitis (AD) is a common inflammatory skin disease that has both genetic and environmental factors in its etiology.1) It is well known that lipids, fatty acids (FAs) and their metabolites play an important role in the control of inflammation in AD.2) There are many reports on the relation between FA composition and inflammation. For example, an abnormal n-6 FA composition in cheek mucosal cells of children with AD 3) and an elevation of serum linoleic acid (18 : 2n-6) level in children with AD compared with that in non-AD children 4) have been observed in studies on AD and lipid metabolism. It has also been observed that arachidonic acid (20 : 4n-6) significantly accumulated in blood cells of NC/Nga mice (an AD animal model) with AD. 2)Using NC/Nga mice, 5,6) we had previously investigated methods for assessing balneotherapy effects on pathogenesis of AD, in which the dermatitis score was used as an index to evaluate inflammation. 7,8) Comprehensive analysis of gene expression in NC/Nga mice with AD revealed significant changes in expression of several genes involved in fatty acid metabolism, such as acetyl CoA carboxylase.8) To our knowledge, however, there have been no reports on FA composition of the skin surface lipids that play an important role in moisturizing and the skin barrier system in AD mouse models. This may be due to difficulty in lipid extraction from mice with hair such as NC/Nga mice.In the present study, we investigated the influence of spring water on the FA composition of skin surface lipids by using a hairless AD mouse model, NCN24 mice (transgenic mice) 9) and reversed-phase HPLC with fluorescence detection (HPLC/ FD).10,11) The spring water examined was available from Toyotomi hot spring (Hokkaido, Japan) that is famous for being effective against AD and psoriasis, and many people from across the country has visited the watering for cure. 12) One of the features of the spring is to include petroleum-containing hot spring water that is rare in Japan. Although there is not enough scientific evide...

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Palmitoleic Acid Calcium Salt: A Lubricant and Bactericidal Powder from Natural Lipids

Cited by 23 publications

References 29 publications

Lubricant and Bactericidal Properties of Calcium Salts of Fatty Acids: Effect of Degree of Unsaturation

Lubricant and Bactericidal Properties of Calcium Salts of Fatty Acids: Effect of Degree of Unsaturation

Computational approaches to the in vitro antibacterial activity of Allium hirtifolium Boiss against gentamicin-resistant Escherichia coli: focus on ribosome recycling factor

Influence of Hot Spring Water on Fatty Acid Composition of Skin Surface Lipids in Hairless Mouse Model of Atopic Dermatitis

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