Palmitoleic acid‐rich oleaginous yeast Scheffersomyces segobiensis DSM 27193 exerts anti‐obesity effects by ameliorating hepatic steatosis and adipose tissue hypertrophy

Abstract

BACKGROUNDYeast biomass, encompassing fatty acids, terpenoids, vitamins, antioxidants, enzymes, and other bioactive compounds have been extensively utilized in food‐related fields. The safety and potential bioactivities of Scheffersomyces segobiensis DSM 27193, an oleaginous yeast strain, are unclear.RESULTSScheffersomyces segobiensis DSM 27193 accumulated large palmitoleic acid (POA) levels (43.4 g kg−1 biomass) according to the results of whole‐cell components. We annotated the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, and predicted the categories and host of the pathogen–host interactions (PHI) genes in S. segobiensis DSM 27193. However, S. segobiensis DSM 27193 did not exert toxic effects in mice. Administration of S. segobiensis DSM 27193 led to substantial weight reduction by diminishing food intake in an obesity mouse model. Additionally, it reversed hepatic steatosis and adipose tissue hypertrophy, and improved abnormalities in serum biochemical profiles such as triglyceride, total cholesterol, low‐density lipoprotein cholesterol, lipopolysaccharide, tumor necrosis factor‐α, interleukin‐1β, and interleukin‐6.CONCLUSIONThis study is the first to illustrate the safety and effects of S. segobiensis DSM 27193 against obesity and offers a scientific rationale for its application in functional food supplements. © 2023 Society of Chemical Industry.

The Mechanism of the Anti-Obesity Effects of a Standardized Brassica juncea Extract in 3T3-L1 Preadipocytes and High-Fat Diet-Induced Obese C57BL/6J Mice

“…Obesity is characterized by the abnormal and excessive buildup of fat in adipose tissue, leading to an unhealthy condition, as outlined by the World Health Organization (WHO) [ 1 , 2 ]. The body mass index (BMI) of an individual is calculated by dividing their weight in kilograms by the square of their height in meters.…”

“…The body mass index (BMI) of an individual is calculated by dividing their weight in kilograms by the square of their height in meters. A BMI score that falls within the range of 25 to 30 is categorized as being overweight or obese [ 1 , 2 , 3 ]. Based on the findings of the WHO’s report on obesity, it has been indicated that there are approximately 1.9 billion adults over the age of 18 who are classified as overweight, with an additional 600 million falling into the category of obesity.…”