2023
DOI: 10.1021/acschemneuro.3c00319
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Palmitoylation Regulates Human Serotonin Transporter Activity, Trafficking, and Expression and Is Modulated by Escitalopram

Christopher R. Brown,
James D. Foster

Abstract: In the central nervous system, serotonergic signaling modulates sleep, mood, and cognitive control. During serotonergic transmission, the synaptic concentration of serotonin is tightly controlled in a spatial and temporal manner by the serotonin transporter (SERT). Dysregulation of this process is implicated in the pathogenesis of major-depressive, obsessive-compulsive, and autism-spectrum disorders, which makes SERT a primary target for prescription therapeutics, most notably selective serotonin reuptake inhi… Show more

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Cited by 4 publications
(1 citation statement)
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“…A combination therapy containing lorcaserin (serotonin 5-HT2C receptor agonist) and buspirone (5-HT1A receptor partial agonist and D3R antagonist as mentioned above) produced modest declines in cocaine self-administration in rhesus monkeys [66]. Serotonin reuptake inhibitors citalopram and escitalopram induced the internalization and decrease in cellular serotonin transporters (SERTs; Figure 1) [67], and decreased compulsive cocaine seeking in mice [65,68]. A double-blind clinical trial compared a placebo with citalopram treatments on the duration of cocaine withdrawal, and provided some evidence for positive effects on the longest duration of withdrawal and negative urine cocaine screens [69].…”
Section: Drugs For Serotoninergic Neuronsmentioning
confidence: 99%
“…A combination therapy containing lorcaserin (serotonin 5-HT2C receptor agonist) and buspirone (5-HT1A receptor partial agonist and D3R antagonist as mentioned above) produced modest declines in cocaine self-administration in rhesus monkeys [66]. Serotonin reuptake inhibitors citalopram and escitalopram induced the internalization and decrease in cellular serotonin transporters (SERTs; Figure 1) [67], and decreased compulsive cocaine seeking in mice [65,68]. A double-blind clinical trial compared a placebo with citalopram treatments on the duration of cocaine withdrawal, and provided some evidence for positive effects on the longest duration of withdrawal and negative urine cocaine screens [69].…”
Section: Drugs For Serotoninergic Neuronsmentioning
confidence: 99%