Palmoplantar pustulosis: Factors causing and influencing the course of the disease

Abstract

Palmoplantar pustulosis (PPP) is a chronic inflammatory disease, most often occurring in middle-aged women. In the course of the condition, painful skin lesions appear on the hands and feet, i.e., areas that are extremely important in everyday life. Therefore, the disease significantly reduces quality of life. The pathogenesis of this disease is poorly understood, although it is known that genetic, immunological and environmental factors play a role in its development. Clinical observations confirm the role of nicotine and contact allergens in the development of the lesions. The skin lesions can also occur as a side effect of certain medications. In some cases, PPP coexists with other diseases, i.e., seronegative arthropathies, as well as celiac and thyroid diseases. There is also a connection between the disease and infectious bacterial foci. Exacerbation of the skin lesions is triggered by stress. Therefore, patients require multidirectional tests, since finding the cause of the disease is essential to administering effective treatment.

Psoriasis, bone and bowel: a comprehensive review and new insights

“…Palmoplantar pustulosis (PPP) is a variant of psoriasis affecting about 18% of psoriatic patients [50,51]. As opposed to PV, PPP is more frequently seen in females at the age of 50-70 years especially in the smokers without a positive family history [51][52][53]. In a Swedish study (1998), it was demonstrated that 8% of PPP patients had CD and 24% of whom showed raised levels of IgA AGAs [54].…”

Pustulose palmo-plantar

“…A PPP é uma dermatose inflamatória crónica, rara, com erupções pustulosas nas palmas ou plantas (1). Afeta principalmente mulheres e fumadores (2). Alguns autores consideram-na variante de psoríase, enquanto outros acreditam ser uma entidade distinta (2).…”

“…Afeta principalmente mulheres e fumadores (2). Alguns autores consideram-na variante de psoríase, enquanto outros acreditam ser uma entidade distinta (2). Caracteriza-se histologicamente por hiperqueratose alternada com focos de paraqueratose e existência de células inflamatórias perivasculares.…”

“…PPP is a rare, chronic inflammatory dermatosis with pustular eruptions on the palms or soles (1). It mainly affects women and smokers (2). Some authors consider it a variant of psoriasis, while others believe it is a distinct entity (2).…”

Principal Component Analysis to Differentiate Patients with Palmoplantar Pustulosis from Those with Palmoplantar Pustular Psoriasis

“…The eccrine gland and duct have nicotine acetylcholine receptors (nAChRs) that are stimulated by smoking, and smoking can alter nAChR expression and result in inflammation 1 . It is known that this inflammatory process begins in the acrosyringia, arising from precipitating factors such as focal infection, smoking, and metal allergy 2 .…”