Palpebral cutaneous melanomas: a review of 17 cases from a tertiary center

Taş, Faruk; Ertürk, Kayhan

doi:10.1111/ijd.14212

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…Therefore, recent studies have focused on the molecular mechanisms underlying melanoma progression and metastases as well as on novel strategies for early effective therapy, including immune checkpoint inhibitors. [24][25][26] However, how to successfully inhibit melanoma metastases remains a major barrier to be overcome. Recently, increasing evidence has revealed that MACF1 plays an essential role in various cellular processes, and is involved in the control of microtubule dynamics that relates with cell proliferation and migration, thereby suggesting that MACF1 function is an important for cellular motility.…”

Section: Discussionmentioning

confidence: 99%

<p>Decreasing Microtubule Actin Cross-Linking Factor 1 Inhibits Melanoma Metastasis by Decreasing Epithelial to Mesenchymal Transition</p>

Wang¹,

Jian²,

Dou³

et al. 2020

CMAR

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Background: The microtubule actin cross-linking factor 1 (MACF1) is involved in cellular migration, adhesion, and invasion processes. Its abnormal expression initiates tumor cell proliferation and metastasis in numerous cancer types. Methods: In this study, we utilized short hair-pin RNA interference of MACF1 to assess the inhibitory effects on the metastatic potential of B16F10 melanoma cells both in vitro and in vivo a mouse model. Results: The MACF1 expression was increased in B16F10 cells-induced tumor tissues; while the down-regulation of MACF1 impacted the B16F10 melanoma cell metastatic behavior by decreasing the ability of colony formation and invasion in vitro as well as inhibiting B16F10 cells-induced tumor growth and lung metastasis in vivo. The results of Western blot and immunohistochemistry indicated that the expression of E-cadherin and Smad-7 was significantly increased whereas the expression of N-cadherin and TGF-β1 was significantly decreased in tumor tissue of mice challenged with the B16F10/MACF1-RNAi cells when compared with the B16F10 cells challenged mice. Conclusion: The data presented in this study demonstrated that down-regulated MACF1 expression decreased B16F10 melanoma metastasis in mice by inhibiting the epithelial to mesenchymal transition program. Thus, MACF1 may be a novel target for melanoma therapy.

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Section: Discussionmentioning

confidence: 99%

<p>Decreasing Microtubule Actin Cross-Linking Factor 1 Inhibits Melanoma Metastasis by Decreasing Epithelial to Mesenchymal Transition</p>

Wang¹,

Jian²,

Dou³

et al. 2020

CMAR

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“…Moreover, 28% of patients will develop recurrence at a new site [13], and roughly one third will have more than one episode of recurrence [3]. Similarly, despite complete excision of the lesion on histopathology, nearly one quarter (21–24%) of patients with EM go on to develop local recurrence [8, 11, 14].…”

Section: Introductionmentioning

confidence: 99%

Conjunctival Melanoma with Ipsilateral, Non-Contiguous Eyelid Involvement: A Case Report and Comprehensive Review of the Literature

2020

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• Concurrent pigmentation of the ipsilateral eyelid can occur in up to 15% of cases of conjunctival melanoma. • While conjunctival melanoma may extend into the eyelid in 1% of cases (AJCC cT3b), cases of noncontiguous conjunctival melanoma and eyelid melanoma are very rare with only 5 clearly documented reports in the English literature. Novel Insights • We report a rare case of conjunctival melanoma with non-contiguous eyelid melanoma and provide a comprehensive review of the literature. • This case highlights the importance of long-term follow-up for patients diagnosed with conjunctival melanoma as some instances of secondary eyelid involvement occur several years following the initial diagnosis.

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National Review of Melanomas in Turkey and Comparison with Clinicopathological Features of Melanomas Diagnosed at a Northwestern Academic Tertiary Center

Buyucek

Gamsızkan

Coşkun

et al. 2021

SN Compr. Clin. Med.

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Palpebral cutaneous melanomas: a review of 17 cases from a tertiary center

Abstract: Palpebral skin melanoma is associated with favorable clinical features, and it is correlated with better survival rates.

Cited by 5 publications

References 13 publications

<p>Decreasing Microtubule Actin Cross-Linking Factor 1 Inhibits Melanoma Metastasis by Decreasing Epithelial to Mesenchymal Transition</p>

<p>Decreasing Microtubule Actin Cross-Linking Factor 1 Inhibits Melanoma Metastasis by Decreasing Epithelial to Mesenchymal Transition</p>

Conjunctival Melanoma with Ipsilateral, Non-Contiguous Eyelid Involvement: A Case Report and Comprehensive Review of the Literature

National Review of Melanomas in Turkey and Comparison with Clinicopathological Features of Melanomas Diagnosed at a Northwestern Academic Tertiary Center

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