Paludisme post-transfusionnel

Saleun, J.P.; Deroff, P.; Simitzis, A. M.; Fade, S.; Férec, C.

doi:10.1051/parasite/19876219

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1989

2021

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Induced and Imported Malaria: Then and Now!

Bruce-Chwatt¹

1989

Travel Medicine

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Induced and Imported Malaria: Then and Now!

Bruce-Chwatt¹

1989

Travel Medicine

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Malaria and liver transplantation

Crafa,

Gugenheim,

Fabianl

et al. 1992

Clinical Transplantation

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Transmission of malaria by liver transplantation has not been previously described. A 45‐year‐old Italian man with hepatocellular carcinoma underwent hepatic transplantation in our center; he had no evidence of prior parasite infection. The donor was an 8‐yr‐old child who had been a resident in an endemic malarial area. Retrospective examination of donor sera by immunofluorescent antibody test showed a high titer (1/10240) to Plasmodium falciparum. Twenty days after liver transplantation the recipient became febrile and neurological disorders appeared. Blood films revealed Plasmodium falciparum. Effective therapy by quinine (Quinoforme) was administred but death occurred 41 days after liver transplantation. Autopsy was not permitted. Retrospective examination of donor liver and spleen specimens (Giemsa staining) showed malarial pigment in both organs, macrophage reaction in the spleen and a suspected intraerythrocytic parasite in a liver biopsy. Transmission of malaria following blood transfusion is well documented but in this case blood products were not contaminated by parasites. We suggest that transmission of malaria in our report may be related to the transplanted liver.

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