Pamidronate disodium antagonizes vitamin D3-induced toxicosis

Uses and Effectiveness of Pamidronate Disodium for Treatment of Dogs and Cats with Hypercalcemia

“…Deterioration of renal function has been noted in humans treated with bisphosphonates, and pamidronate (1.05-2.0 mg/kg) was therefore given as a slow (approximately 4-hour) IV infusion diluted in normal saline as described for treatment of hypervitaminosis D in dogs. 16 Pamidronate administration was preceded and followed by a minimum of 4 hours of diuresis with IV fluids. Nephrotoxicity was not identified in the animals in our study by using this infusion protocol.…”

“…Previous reports have demonstrated that pamidronate can be used effectively to correct hypercalcemia caused by calcipotriene 5 and vitamin D 3 -induced toxicosis in dogs. 16 In one study, pamidronate was administered at 1.3-2.0 mg/kg and effectively lowered serum calcium concentrations. 16 A repeated dose of pamidronate 1 week later was found to be safe in dogs with hypervitaminosis D. 23 The doses of pamidronate used in the animals in our study ranged from 1.05 to 2.0 mg/kg.…”

“…16 In one study, pamidronate was administered at 1.3-2.0 mg/kg and effectively lowered serum calcium concentrations. 16 A repeated dose of pamidronate 1 week later was found to be safe in dogs with hypervitaminosis D. 23 The doses of pamidronate used in the animals in our study ranged from 1.05 to 2.0 mg/kg. These doses were chosen based on reports of the successful use of pamidronate as a treatment for dogs with hypervitaminosis D. Large patient size and cost of the drug lead clinicians to choose doses lower than reported in the literature for 1 of these animals.…”

“…11 The bisphosphonates recently have been used in human medicine to treat osteoporosis, glucocorticoid-induced osteoporosis, 11 osteitis deformans, heterotropic ossification, hypercalcemia of malignancy in patients with breast cancer or multiple myeloma, 12,13 and bone metastasis. 14,15 In veterinary medicine, the bisphosphonate pamidronate has been used to treat hypercalcemia caused by cholecalciferol intoxication 5,16,17 and hypercalcemia of malignancy, 18 and alendronate has been used in the palliative management of osteosarcoma. 19 The purpose of our study was to describe the use of pamidronate in 7 dogs and 2 cats with hypercalcemia caused by calcipotriene ingestion (3 dogs), nocardia infection (1 cat), lymphosarcoma (2 dogs), thyroid carcinoma (1 dog), idiopathic hypercalcemia and chronic renal failure (1 cat), and multiple endocrine neoplasia (1 dog).…”

Study of Thermal Behavior of Vitamin D3 by Pyrolysis ‐ GC ‐ MS in Combination with Boiling Point ‐ Retention Time Correlation

“…2,3 Now, it is also used to suppress cancer cell proliferation in the clinical practice. [5][6][7][8] To evaluate the potential influence of the broiled foods, the fry, and the foods on fire of their storage, it is necessary to know the ingredients variation of the vitamin D 3 that exists as crude and/or additive forms in the foods under high temperature. 4 However, with the increasing concern about food security, many countries have announced to forbid the use of vitamin D 3 in certain foods for some reasons.…”