Pan-alimentary assessment of motility, luminal content, and structures: an MRI-based framework

Bertoli, Davide; Mark, Esben Bolvig; Liao, Donghua; Brock, Christina; Brock, Birgitte; Knop, Filip K.; Krogh, Klaus; Frøkjær, Jens Brøndum; Drewes, Asbjørn Mohr

doi:10.1080/00365521.2023.2233036

Cited by 5 publications

(1 citation statement)

References 65 publications

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“…A previously described panenteric MRI framework was utilized in this study [ 15 ]. In this paper, we will only briefly outline the methods.…”

Section: Methodsmentioning

confidence: 99%

MRI-Based Quantification of Pan-Alimentary Function and Motility in Subjects with Diabetes and Gastrointestinal Symptoms

Bertoli,

Mark,

Liao

et al. 2023

JCM

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Background: Diabetes-induced gastrointestinal (GI) symptoms are common but difficult to correctly diagnose and manage. We used multi-segmental magnetic resonance imaging (MRI) to evaluate structural and functional GI parameters in diabetic patients and to study the association with their symptomatic presentation. Methods: Eighty-six participants (46 with diabetes and GI symptoms, 40 healthy controls) underwent baseline and post-meal MRI scans at multiple timepoints. Questionnaires were collected at inclusion and following the scans. Data were collected from the stomach, small bowel, and colon. Associations between symptoms and collected data were explored. Utilizing machine learning, we determined which features differentiated the two groups the most. Key Results: The patient group reported more symptoms at inclusion and during MRI scans. They showed 34% higher stomach volume at baseline, 40% larger small bowel volume, 30% smaller colon volume, and less small bowel motility postprandially. They also showed positive associations between gastric volume and satiety scores, gastric emptying time and reflux scores, and small bowel motility and constipation scores. No differences in gastric emptying were observed. Small bowel volume and motility were used as inputs to a classification tool that separated patients and controls with 76% accuracy. Conclusions: In this work, we studied structural and functional differences between patients with diabetes and GI symptoms and healthy controls and observed differences in stomach, small bowel, and colon volumes, as well as an adynamic small bowel in patients with diabetes and GI symptoms. Associations between recorded parameters and perceived symptoms were also explored and discussed.

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“…A previously described panenteric MRI framework was utilized in this study [ 15 ]. In this paper, we will only briefly outline the methods.…”

Section: Methodsmentioning

confidence: 99%

MRI-Based Quantification of Pan-Alimentary Function and Motility in Subjects with Diabetes and Gastrointestinal Symptoms

Bertoli,

Mark,

Liao

et al. 2023

JCM

Self Cite

View full text Add to dashboard Cite

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Pan‐Alimentary Magnetic Resonance Imaging of Severe Gastroparesis May Facilitate Diagnosis and Treatment

Engelbrecht,

Videbech,

Ilkjær

et al. 2024

Clinical Case Reports

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Gastrointestinal disease in systemic sclerosis: the neglected organ system?

McMahan,

Pandolfino,

Perlman

et al. 2024

Current Opinion in Rheumatology

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Purpose of review Identifying outcomes and clinical trial endpoints enabled the discovery of new inflammatory bowel disease (IBD) treatments. Herein, we describe efforts to advance the study of gastrointestinal (GI) manifestations in systemic sclerosis (SSc). Recent findings Insights into the scope of the problem, as well as advancements in the measurement and treatment of SSc-GI, are underway. Proposed SSc esophageal endophenotypes are now defined, risk stratification methods are growing, and imaging and functional studies are now employed to guide therapeutic interventions. Additional progress is being made in characterizing the gut microbiome in patients with SSc. Research into the role of the immune response in the pathogenesis of SSc-GI disease is also ongoing, evolving simultaneously with the development of methods to facilitate data collection with real-time capture of diet, exercise, and medication data. Summary Multidisciplinary teams are working to deepen our understanding of SSc-GI disease pathogenesis, to identify biomarkers for risk stratification and the assessment of disease activity, and to develop and validate outcomes and clinical trial endpoints to pave the way toward effective therapy for SSc-GI disease.

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Pan-alimentary assessment of motility, luminal content, and structures: an MRI-based framework

Cited by 5 publications

References 65 publications

MRI-Based Quantification of Pan-Alimentary Function and Motility in Subjects with Diabetes and Gastrointestinal Symptoms

MRI-Based Quantification of Pan-Alimentary Function and Motility in Subjects with Diabetes and Gastrointestinal Symptoms

Pan‐Alimentary Magnetic Resonance Imaging of Severe Gastroparesis May Facilitate Diagnosis and Treatment

Gastrointestinal disease in systemic sclerosis: the neglected organ system?

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