Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with gastric cancer

Shitara, K.; Fleitas, T.; Kawakami, H.; Curigliano, G.; Narita, Y.; Wang, F.; Wardhani, S.O.; Basade, M.; Rha, S.Y.; Wan Zamaniah, W.I.; Sacdalan, D.L.; Ng, M.; Yeh, K.H.; Sunpaweravong, P.; Sirachainan, E.; Chen, M.-H.; Yong, W.P.; Peneyra, J.L.; Ibtisam, M.N.; Lee, K.-W.; Krishna, V.; Pribadi, R.R.; Li, J.; Lui, A.; Yoshino, T.; Baba, E.; Nakayama, I.; Pentheroudakis, G.; Shoji, H.; Cervantes, A.; Ishioka, C.; Smyth, E.

doi:10.1016/j.esmoop.2023.102226

ESMO Open

2024

DOI: 10.1016/j.esmoop.2023.102226

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Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with gastric cancer

K. Shitara,

T. Fleitas,

H. Kawakami

et al.

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Cited by 19 publications

References 79 publications

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Is there any difference between Eastern and Western clinical practice guidelines in management of gastric cancer?

Jalaeefar,

Mousavi,

Shirkhoda

et al. 2024

Cancer Reports

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Background and Recent findingsGastric cancer (GC) has been known as one of the most common causes of cancer mortality both in Western and Eastern countries. However, there might be differences between how it is managed in different countries. Thus, we aimed to investigate these differences.Materials and MethodsThe most well‐known clinical guidelines in field of GC management including Korean GC Association (KGCA), Japanese GC Association (JGCA), National Comprehensive Cancer Network (NCCN), European Society for Medical Oncology (ESMO), British Society of Gastroenterology (BSG), and National Institute for health and Care Excellence (NICE) have been reviewed.ResultsThe contents of these guidelines were categorized under eight headings including (1) genetic predisposition, (2) prevention, (3) management of gastric polyp, atrophy, dysplasia and metaplasia, (4) diagnosis, (5) pathology and molecular biology, (6) treatment, (7) supportive and palliative care, and (8) follow up. Difference in each section was discussed.ConclusionConsidering KGCA and JGCA as Eastern and NCCN, ESMO, BSG, and NICE as Western guidelines, it is revealed that both sets of guidelines share common practices such as prioritizing comprehensive diagnostic evaluations, personalizing treatment plans, and palliative care. However, main differences can be seen in treatment regimens, the adoption of newer therapies like immunotherapy, and the utilization of emerging techniques such as HIPEC. These differences reflect the diverse clinical landscapes, research focuses, and healthcare systems within these regions.

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Is there any difference between Eastern and Western clinical practice guidelines in management of gastric cancer?

Jalaeefar,

Mousavi,

Shirkhoda

et al. 2024

Cancer Reports

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Comprehensive histopathological analysis of gastric cancer in European and Latin America populations reveals differences in PDL1, HER2, p53 and MUC6 expression

Martínez-Ciarpaglini,

Barros,

Caballero

et al. 2025

Gastric Cancer

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Introduction Gastric cancer (GC) burden is currently evolving with regional differences associated with complex behavioural, environmental, and genetic risk factors. The LEGACy study is a Horizon 2020-funded multi-institutional research project conducted prospectively to provide comprehensive data on the tumour biological characteristics of gastroesophageal cancer from European and LATAM countries. Material and methods Treatment-naïve advanced gastroesophageal adenocarcinoma patients were prospectively recruited in seven European and LATAM countries. Formalin-fixed paraffin-embedded primary tumour endoscopic biopsy samples were collected and submitted for central morphological and immunohistochemical characterization and TP53 molecular assessment and Helicobacter pylori infection. Results A total of 259 patients were included in the study: 137 (53%) from LATAM and 122 (47%) from Europe. Significant biological differences were detected between European and LATAM patients. Low representation of chromosomal instability (CIN) and HER2 positive cases were found in LATAM. MUC6 and PD-L1 were more frequently overexpressed in European cases, showing a significant correlation across the entire study population, with this association being especially pronounced in MMRdeficient cases. Both TP53 mutation by next-generation sequencing and p53 immunohistochemical aberrant pattern were linked with features associated with chromosomal instability. No regional differences were observed in H. pylori prevalence or abundance, indicating that the afore mentioned variations cannot be attributed to this factor. Conclusion Our findings underscore a need for region-specific approaches in gastroesophageal cancer diagnosis and treatment. MUC6 emerges as a putative immune regulator that needs further investigation. Research tailored to the unique biological profiles in different global regions is crucial to effectively address the observed disparities.

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Biomarker-oriented chemo-immunotherapy for advanced gastric cancer

Kono,

Nakajima,

Mimura

2024

Int J Clin Oncol

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Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with gastric cancer

Cited by 19 publications

References 79 publications

Is there any difference between Eastern and Western clinical practice guidelines in management of gastric cancer?

Is there any difference between Eastern and Western clinical practice guidelines in management of gastric cancer?

Comprehensive histopathological analysis of gastric cancer in European and Latin America populations reveals differences in PDL1, HER2, p53 and MUC6 expression

Biomarker-oriented chemo-immunotherapy for advanced gastric cancer

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