2020
DOI: 10.1200/jco.2020.38.15_suppl.3620
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Pan-cancer analysis of FGFR1-3 genomic alterations to reveal a complex molecular landscape.

Abstract: 3620 Background: Activating genomic alterations (GAs) in the fibroblast growth factor receptor (FGFR) gene family occur in many tumor types. FGFR1-3 mutations and rearrangements are of particular interest given evidence of clinical activity of selective FGFR inhibitors in patients (pts) with susceptible alterations. We queried FGFR1-3 GAs in patient tumor samples analyzed using comprehensive genomic profiling (CGP) and performed in vitro characterization of select novel alterations. Methods: Tumor samples wer… Show more

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Cited by 10 publications
(15 citation statements)
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“…In a separate retrospective analysis of 274,694 patient tumour samples, genomic alterations in FGFR1–3 (FGFR4 was not assessed) were detected by next-generation sequencing in 2.3% of patient specimens, of which 64.8% were SNVs and 35.9% were rearrangements. 12 In both studies, almost all tumour types were found to have FGFR alterations, but those with the highest alteration frequency included urothelial cancer, cholangiocarcinoma, endometrial cancer, squamous lung cancers, breast cancer and cervical cancer. 3 , 12 In this section, we catalogue the diversity of FGFR SNVs, gene fusions and CNAs.…”
Section: Fgfr Alterations In Cancermentioning
confidence: 91%
See 3 more Smart Citations
“…In a separate retrospective analysis of 274,694 patient tumour samples, genomic alterations in FGFR1–3 (FGFR4 was not assessed) were detected by next-generation sequencing in 2.3% of patient specimens, of which 64.8% were SNVs and 35.9% were rearrangements. 12 In both studies, almost all tumour types were found to have FGFR alterations, but those with the highest alteration frequency included urothelial cancer, cholangiocarcinoma, endometrial cancer, squamous lung cancers, breast cancer and cervical cancer. 3 , 12 In this section, we catalogue the diversity of FGFR SNVs, gene fusions and CNAs.…”
Section: Fgfr Alterations In Cancermentioning
confidence: 91%
“… 12 In both studies, almost all tumour types were found to have FGFR alterations, but those with the highest alteration frequency included urothelial cancer, cholangiocarcinoma, endometrial cancer, squamous lung cancers, breast cancer and cervical cancer. 3 , 12 In this section, we catalogue the diversity of FGFR SNVs, gene fusions and CNAs.…”
Section: Fgfr Alterations In Cancermentioning
confidence: 91%
See 2 more Smart Citations
“…A recent study provides a glimpse at the burden FGFR isoform 1-3 alterations in cancer. 7 A total of 274,694 tumor specimens were analyzed, and 6314 specimens contained FGFR1-3 alterations (2.3%). Multiple cancer types were found to have FGFR alterations including bladder cancer, cholangiocarcinoma, endometrial cancer, glioma, kidney cancer, cervix cancer, head and neck cancers, melanoma, and plasma cell neoplasms.…”
Section: Fgfr Inhibitorsmentioning
confidence: 99%