Pan-Cancer Analysis of Genomic and Prognostic Characteristics Associated With Coronavirus Disease 2019 Regulators

Zhang, Jian; Jiang, Huali; Du, Kunpeng; Xie, Tao; Wang, Baiyao; Chen, Chengcong; Cen, Bohong; Yuan, Yawei; Ye, Jiacai

doi:10.3389/fmed.2021.662460

Cited by 7 publications

(7 citation statements)

References 42 publications

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“…Some studies reported challenges brought on by COVID‐19 infection in single cancers 41,42 and influences of changes in COVID‐19 receptor–related regulators across different cancers 43,44 . A large number of studies have employed Kaplan–Meier survival analyses to construct prognostic modules to identify better treatments.…”

Section: Discussionmentioning

confidence: 99%

How does SARS‐CoV‐2 infection impact on immunity, procession and treatment of pan cancers

Xiong

Jiang

2023

Journal of Medical Virology

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We identified 14 immune-related differentially Expressed Genes (DEGs) between COVID-19 patients and normal controls and the receiver operator characteristic curve results showed that they could be used to discriminate COVID-19 patients from healthy controls. Single-sample gene set enrichment analysis and CIBERSORT analysis displayed immune landscape of COVID-19 patients that the fraction of immune cells (like B cell subtypes and T cell subtypes) decreased distinctly in the first SARS-CoV-2 infection which may further weaken immunity of cancer patients and increasing inflammatory cells (Neutrophils and Macrophages) may further promote inflammatory response of cancer patients. Based on expression levels of 14 DEGs we found that first SARS-CoV-2 infection may accelerate progression of cancer patients by Kaplan-Meier survival, immune subtypes and tumor microenvironment analyses, and may weaken anti-PD-1 monoclonal antibody treatment effect of cancer patients by weighted gene co-expression network, tumor mutation burden and microsatellite instability analysis. The second SARS-CoV-2 infection was beneficial to control development of tumor seemingly, but it may be difficult for cancer patients to experience destroy successfully from first SARS-CoV-2 infection, let alone benefits from second SARS-CoV-2 infection. In addition, this study also emphasized significance of multi-factor analysis when analyzing impacts of SARS-CoV-2 infection on cancer patients.

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Section: Discussionmentioning

confidence: 99%

How does SARS‐CoV‐2 infection impact on immunity, procession and treatment of pan cancers

Xiong

Jiang

2023

Journal of Medical Virology

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“…Copy number variation (CNV) data and methylation data were gathered from the TCGA. We used the GTEx database to analyze gene performance in normal tissues ( 26 ).…”

Section: Methodsmentioning

confidence: 99%

“…The hypermethylation group exhibited worse survival if the hazard ratio was >0. Hyper-worse was classified as high risk; otherwise, it was considered low risk ( 26 ).…”

Section: Methodsmentioning

confidence: 99%

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Pan-cancer analysis of AIM2 inflammasomes with potential implications for immunotherapy in human cancer: A bulk omics research and single cell sequencing validation

et al. 2022

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BackgroundThe absent in melanoma 2 (AIM2) inflammasome is a multi-protein platform that recognizes aberrant cytoplasmic double-stranded DNA(dsDNA) and induces cytokine maturation, release, and pyroptosis. Some studies found that the AIM2 inflammasome was a double-edged sword in many cancers. However, there have been fewer studies on AIM2 inflammasomes in pan-cancer.MethodsGene expression was analyzed using The Cancer Genome Atlas (TCGA) database and The Genotype-Tissue Expression (GTEx) database. Immunohistochemistry (IHC) was used to validate the expression of the AIM2. We used the survival curve to explore the prognostic significance of the AIM2 inflammasomes in pan-cancer. Mutations and methylation of AIM2 inflammasome-related genes (AIM2i-RGs) were also comprehensively analyzed. Single sample gene set enrichment analysis was used to calculate the AIM2 inflammasomes score and explore the correlation of the AIM2 inflammasomes score with immune-related genes and immune infiltrations. The function of AIM2 inflammasomes in pan-cancer was analyzed at the single-cell level. Single-cell transcriptome sequencing (scRNA-seq) data was used to assess the activation state of the AIM2 inflammasomes in the tumor microenvironment.ResultsWe found that AIM2i-RGs were aberrantly expressed in tumors and were strongly associated with prognosis. In pan-cancer, the expression of AIM2i-RGs was positively associated with copy number variation and negatively associated with methylation. In AIM2i-RGs, missense mutations were the predominant type of single nucleotide polymorphism. Moreover, we found that the drugs dimethyloxallyl glycine (DMOG) and Z-LNle-CHO may be sensitive to the AIM2 inflammasomes. The AIM2 inflammasomes score was significantly and positively correlated with the tumor immunity score and the stroma score. In most tumors, the AIM2 inflammasomes score was significantly and positively correlated with CD8+ T cell abundance in the tumor microenvironment. Additionally, the AIM2 inflammasomes score was significantly correlated with immune checkpoint genes in pan-cancer as well as immune checkpoint therapy-related markers including tumor mutational burden (TMB), microsatellite instability(MSI), and tumor immune dysfunction and exclusion(TIDE). scRNA-seq analysis suggested that AIM2 inflammasomes differ significantly among different cells in the tumor microenvironment. IHC confirmed low expression of AIM2 in colorectal cancer.DiscussionAIM2 inflammasomes may be a new target for future tumor therapy It is likely involved in tumor development, and its high expression may serve as a predictor of tumor immunotherapy efficacy.

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“…The genomic alterations of six SARS-CoV-2 receptor-related regulators [transmembrane serine protease 2 (TMPRSS2), angiotensinogen (AGT), ACE1, solute carrier family 6 member 19 (SLC6A19), ACE2, and angiotensin II receptor type 2 (AGTR2)] and their clinical relevance across a broad spectrum of solid tumors were also evaluated across 33 cancers. This may clarify the potential mechanisms of tumorigenesis and provide a novel approach to cancer treatments [30] . Furthermore, four major similar signaling pathway, have been identified at the intersection of COVID-19 and cancer; namely, cytokine, type I interferon (IFN-I), androgen receptor (AR), and immune checkpoint signaling.…”

Section: Sars-cov-2 and Cancer Interactionsmentioning

confidence: 99%

SARS-CoV-2 and cancer: the intriguing and informative cross-talk

Goubran

Stakiw

Seghatchian

et al. 2022

Transfusion and Apheresis Science

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Pan-Cancer Analysis of Genomic and Prognostic Characteristics Associated With Coronavirus Disease 2019 Regulators

Cited by 7 publications

References 42 publications

How does SARS‐CoV‐2 infection impact on immunity, procession and treatment of pan cancers

How does SARS‐CoV‐2 infection impact on immunity, procession and treatment of pan cancers

Pan-cancer analysis of AIM2 inflammasomes with potential implications for immunotherapy in human cancer: A bulk omics research and single cell sequencing validation

SARS-CoV-2 and cancer: the intriguing and informative cross-talk

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