Pan-Cancer TCGA Analysis Reveals the Potential Involvement of Lamin B2 in Dysregulating Chromosome Segregation in Human Cancer

Abstract

Lamins are fibrous proteins present just beneath the inner nuclear membrane and play a crucial role in shaping the genomic architecture. Several studies have reported the association of lamins with disease conditions such as cancer. Despite significant progress, the prognostic significance and underlying molecular targets of B-type lamins, especially lamin B2 in pan-cancer, have not been well studied. In this study, we have explored through bioinformatic analysis the potential functions of lamin B2 in driving cancer and its prognostic significance across pan-cancer TCGA datasets. Our results indicate the overexpression of lamin B2 in multiple human cancers, which is also correlated with poor overall and disease-free survival. Besides this, higher lamin B2 is associated with CD4+ Th1 and Th2 cell infiltration. We have identified 9 lamin B2 interacting proteins that are co-expressed with lamin B2 in cancerous conditions and, together with lamin B1, regulate cytokinesis and cell division pathways. Furthermore, we have identified specific molecular targets and independent functions of lamin B2 in dysregulating chromosome segregation and mRNA binding in multiple cancers. Our study, for the first time, has demonstrated the potential functions of lamin B2 and its prognostic significance across different cancers.