Pan-uvéite dans les suites d’instillations intravésicales de BCG (Bacille de Calmette et Guérin)

Jacob, M.; Gambrelle, J.; Fleury, J.; Durieu, I.; Kodjikian, Laurent; Duquesne, N; Grangé, J.D.

doi:10.1016/s0181-5512(06)73809-8

Cited by 19 publications

(3 citation statements)

References 7 publications

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“…Patients may also present with systemic symptoms resembling reactive arthritis [191-193]. Less commonly, patients may present with bilateral panuveitis [194,195], chorioretinitis [196], vitiligo [189], and/or optic neuritis [195]. …”

Section: Reviewmentioning

confidence: 99%

Drug-induced uveitis

London

Moorthy

Cunningham

2013

J OPHTH INFLAMM INFECT

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Section: Reviewmentioning

confidence: 99%

Drug-induced uveitis

London

Moorthy

Cunningham

2013

J OPHTH INFLAMM INFECT

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“…The mechanism behind this phenomenon is immune sensitization revealed by BCG with cross-reaction against the ocular antigen. Bilateral panuveitis (Jacob et al 2006 ), chorioretinitis (Guex-Crosier et al 2003 ), and/or optic neuritis (Hegde and Dean 2005 ) are rarely seen in patients, and mycobacterial choroiditis has been reported in only two previous case reports (Guex-Crosier et al 2003 ).…”

Section: Discussionmentioning

confidence: 99%

Vogt–Koyanagi–Harada disease following BCG vaccination and tuberculosis

2016

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Introduction To describe the characteristics, diagnosis, and treatment of the first documented case of Vogt–Koyanagi–Harada (VKH) disease following BCG vaccination (Patient 1) and the first documented case of both VKH disease and tuberculosis (Patient 2).Two patients were diagnosed with VKH disease and monitored using fundus photography, fundus autofluorescence, fluorescein angiography (FA), spectral-domain optical coherence tomography, and enhanced depth imaging optical coherence tomography (EDI-OCT).Case description A 39-year-old patient (Patient 1) had bilateral granulomatous anterior uveitis and serous retinal detachment. FA showed multiple punctuate hyperfluorescent lesions and multilobular pools of dye. EDI-OCT revealed serous retinal detachment, subretinal septa, and cystoid spaces. A 40-year-old woman (Patient 2) presented with a 3-week history of decreased vision, headache and tinnitus. Fundus examination showed bilateral disc swelling with serous retinal detachment and retinal folds. She had been diagnosed with tuberculosis. EDI-OCT showed fluctuation of the internal limiting membrane (ILM), retinal folds, retinal pigment epithelial (RPE)-Bruch membrane undulation, choroidal folds, serous retinal detachment. Both of the patients received high dosage of steroid treatment during the diagnosis. A fast recovery in VKH symptoms was observed following the treatment.Discussion and evaluationImmunological mechanisms and dysregulation of the immune system may play a significant role in the association between VKH disease and BCG.ConclusionsEDI-OCT imaging demonstrated structural changes in the photoreceptor layer, RPE-Bruch membrane, choroid, outer retina, ILM in acute VKH.

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“…There are also rare cases described in the literature of some other major complications such as mycotic abdominal aortic aneurysm [8], infection of an implantable defibrillator [9], vertebral osteomyelitis [10] and bilateral panuveitis [11]. No infection of the pancreatic head was found in a review of the literature on PubMed.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic and psoas abscesses as a late complication of intravesical administration of bacillus Calmette-Guerin for bladder cancer: a case report and review of the literature

et al. 2009

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IntroductionBacillus Calmette-Guerin (BCG) is a live attenuated strain of Mycobacterium bovis that has been used to treat urothelial carcinoma since 1976, and has been reported to eradicate disease in more than 70% of patients with in situ and stage I disease. To the best of our knowledge, we report the first case of disseminated bacillus Calmette-Guerin infection causing multiple abscesses affecting the pancreatic head and right psoas muscle, diagnosed 5 years after intravesical treatment with bacillus Calmette-Guerin therapy for bladder cancer.Case presentationAn 83-year-old Caucasian man was hospitalized with a 2-month history of back pain, anorexia, generalized weakness and a 47-pound weight loss. He had previously undergone two transurethral resections for high-grade transitional cell carcinoma of the bladder and had received 12 intravesical bacillus Calmette-Guerin instillations without any complications. He complained of abdominal pain in his right flank. A computed tomography scan of the abdomen showed multiple abscesses affecting the pancreatic head and right psoas muscle. Growth of Mycobacterium bovis was determined in cultures of the purulent material obtained by surgical drainage of the abscesses.ConclusionsThis case illustrates the fact that although intravesical administration of bacillus Calmette-Guerin is generally considered to be safe, it is not exempt from complications and these could appear immediately after treatment or as a delayed complication many years later.

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Pan-uvéite dans les suites d’instillations intravésicales de BCG (Bacille de Calmette et Guérin)

Cited by 19 publications

References 7 publications

Drug-induced uveitis

Drug-induced uveitis

Vogt–Koyanagi–Harada disease following BCG vaccination and tuberculosis

Pancreatic and psoas abscesses as a late complication of intravesical administration of bacillus Calmette-Guerin for bladder cancer: a case report and review of the literature

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