Panax ginseng and aging related disorders: A systematic review

Zanuso, Bárbara de Oliveira; Santos, Ana Rita de Oliveira dos; Miola, Vitor Fernando Bordin; Campos, Leila M Gissoni; Spilla, Caio Sérgio Galina; Barbalho, Sandra Maria

doi:10.1016/j.exger.2022.111731

Cited by 61 publications

(32 citation statements)

References 111 publications

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“…Sarcopenia, from the Greek sarx for "meat" and penia for "loss" is a multifactorial condition related to the loss of muscle mass due to aging, eating habits, physical inactivity, or even caused by another disease [1,2]. Currently, it has been discussed with a focus on muscle function, such as muscle strength, instead of only based on muscle mass [3,4].…”

Section: Introductionmentioning

confidence: 99%

Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review

et al. 2023

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Sarcopenia is a multifactorial condition related to the loss of muscle mass and strength due to aging, eating habits, physical inactivity, or even caused by another disease. Affected individuals have a higher risk of falls and may be associated with heart disease, respiratory diseases, cognitive impairment, and consequently an increased risk of hospitalization, in addition to causing an economic impact due to the high cost of care during the stay in hospitals. The standardization of appropriate treatment for patients with sarcopenia that could help reduce pathology-related morbidity is necessary. For these reasons, this study aimed to perform a systematic review of the role of nutrition and drugs that could ameliorate the health and quality of life of sarcopenic patients and PRISMA guidelines were followed. Lifestyle interventions have shown a profound impact on sarcopenia treatment but using supplements and different drugs can also impact skeletal muscle maintenance. Creatine, leucine, branched-chain amino acids, omega 3, and vitamin D can show benefits. Although with controversial results, medications such as Metformin, GLP-1, losartan, statin, growth hormone, and dipeptidyl peptidase 4 inhibitors have also been considered and can alter the sarcopenic’s metabolic parameters, protect against cardiovascular diseases and outcomes, while protecting muscles.

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Section: Introductionmentioning

confidence: 99%

Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review

et al. 2023

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“…Panax ginseng and Panax notoginseng are often used to slow down the symptoms, such as traumatic injury, blood stasis, swelling and pain ( Tianhong et al, 2014 ; Chen et al, 2017 ; Wu et al, 2018 ). The ginsenosides, chemical constituents found in Panax ginseng and Panax notoginseng, can inhibit the effects of inflammatory cytokines, block signaling pathways that induce inflammation, and inhibit cells that participate in inflammatory processes ( de Oliveira Zanuso et al, 2022 ). What’s more, increasing evidence has demonstrated that ginsenosides are involved in neuroprotective effects in the central nervous system diseases due to their antioxidant, anti-apoptotic, and anti-inflammatory features ( Lu et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Mechanisms of Ginsenoside Rb1 in Central Nervous System Diseases

et al. 2022

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Panax ginseng and Panax notoginseng, two well-known herbs with enormous medical value in Asian countries, have a long usage history in China for the therapy of some diseases, such as stroke. Ginsenoside Rb1 is one of most important active ingredients in Panax ginseng and Panax notoginseng. In the last two decades, more attention has focused on ginsenoside Rb1 as an antioxidative, anti-apoptotic and anti-inflammatory agent that can protect the nervous system. In the review, we summarize the neuroprotective roles of ginsenoside Rb1 and its potential mechanisms in central nervous system diseases (CNSDs), including neurodegenerative diseases, cerebral ischemia injury, depression and spinal cord injury. In conclusion, ginsenoside Rb1 has a potential neuroprotection due to its inhibition of oxidative stress, apoptosis, neuroinflammation and autophagy in CNSDs and may be a promising candidate agent for clinical therapy of CNSDs in the future.

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“…Two well-known adaptogenic plants [4][5][6][7][8][9], Red Ginseng (Panax ginseng CA Mey) [10] and Red Sage/Danshen (Salvia miltiorrhiza Bunge) [11], are used in Traditional Chinese Medicine (TCM) as an effective treatment of diseases and conditions associated with inflammaging and aging-related diseases [4][5][6][7][8][9][10][11][12][13][14][15][16][17]. In Europe, Red Ginseng (RG) is approved as an herbal medicinal product to enhance cognitive functions and physical capacities in weakness, loss of concentration, exhaustion, tiredness, and convalescence [10].…”

Section: Introductionmentioning

confidence: 99%

Network Pharmacology of Ginseng (Part III): Antitumor Potential of a Fixed Combination of Red Ginseng and Red Sage as Determined by Transcriptomics

Panossian¹,

Abdelfatah

Efferth

2022

Pharmaceuticals

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Background: This study aimed to assess the effect of a fixed combination of Red Ginseng and Red Sage (RG–RS) on the gene expression of neuronal cells to evaluate the potential impacts on cellular functions and predict its relevance in the treatment of stress and aging-related diseases and disorders. Methods: Gene expression profiling was conducted by transcriptome-wide mRNA microarray analyses of murine HT22 hippocampal cell culture after treatment with RG–RS preparation. Ingenuity pathway analysis (IPA) was performed with datasets of significantly upregulated or downregulated genes and the expected effects on the physiological and cellular function and the diseases were identified. Results: RG–RS deregulates 1028 genes associated with cancer and 139 with metastasis, suggesting a predicted decrease in tumorigenesis, the proliferation of tumor cells, tumor growth, metastasis, and an increase in apoptosis and autophagy by their effects on the various signaling and metabolic pathways, including the inhibition of Warburg’s aerobic glycolysis, estrogen-mediated S-phase entry signaling, osteoarthritis signaling, and the super-pathway of cholesterol biosynthesis. Conclusion: The results of this study provide evidence of the potential efficacy of the fixed combination of Red Ginseng (Panax ginseng C.A. Mey.) and Red Sage/Danshen (Salvia miltiorrhiza Bunge) in cancer. Further clinical and experimental studies are required to assess the efficacy and safety of RG–RS in preventing the progression of cancer, osteoarthritis, and other aging-related diseases.

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Panax ginseng and aging related disorders: A systematic review

Cited by 61 publications

References 111 publications

Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review

Insights into Pathogenesis, Nutritional and Drug Approach in Sarcopenia: A Systematic Review

Neuroprotective Mechanisms of Ginsenoside Rb1 in Central Nervous System Diseases

Network Pharmacology of Ginseng (Part III): Antitumor Potential of a Fixed Combination of Red Ginseng and Red Sage as Determined by Transcriptomics

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