Panax ginseng as a potential therapeutic for neurological disorders associated with COVID-19; Toward targeting inflammasome

Shin, Seo Won; Cho, Ik Hun

doi:10.1016/j.jgr.2022.09.004

Cited by 5 publications

(2 citation statements)

References 93 publications

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“…Currently, there are no known specific treatments that can inhibit SARS-CoV-2 infection and cure neurological symptoms such as depression caused by the infection. Due to the lack of definitive treatment options, natural remedies like ginseng and its derivatives are widely employed as immune boosters or health supplements to prevent SARS-CoV-2 infection and alleviate neurological manifestations, including depression, associated with COVID-19 (Shin and Cho 2023 ; Tian et al 2022 ). Ginseng, along with its key active components such as ginsenosides and saponins, exhibits immunomodulatory properties and anti-inflammatory effects by modulating inflammasome activity (Jung and Lee 2022 ).…”

Section: Effects Of Ginseng On Covid-19 Pandemic Caused Depressionmentioning

confidence: 99%

“…In China, ginseng is the "king of herbs" and "the first of the three treasures of traditional chinese medicine". Ginseng was reported to have pharmacological effects on anti-inflammatory, antioxidant, immunostimulant, and antiaging effects(Liu et al 2021a ; Shin and Cho 2023 ; Han et al 2022 ; Kwon et al 2023 ; Su et al 2023 ). In addition, ginseng can regulate the excitability of neurons in the central nervous system (CNS) and produce neuroprotective effects (Liu et al 2020a ; Gong et al 2022 ; Kim et al 2022 ).…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic potential and possible mechanisms of ginseng for depression associated with COVID-19

Zhao,

Zhang,

Chen

et al. 2023

Inflammopharmacol

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Recently, a global outbreak of COVID-19 has rapidly spread to various national regions. As the number of COVID-19 patients has increased, some of those infected with SARS-CoV-2 have developed a variety of psychiatric symptoms, including depression, cognitive impairment, and fatigue. A distinct storm of inflammatory factors that contribute to the initial disease but also a persistent post-acute phase syndrome has been reported in patients with COVID-19. Neuropsychological symptoms including depression, cognitive impairment, and fatigue are closely related to circulating and local (brain) inflammatory factors. Natural products are currently being examined for their ability to treat numerous complications caused by COVID-19. Among them, ginseng has anti-inflammatory, immune system stimulating, neuroendocrine modulating, and other effects, which may help improve psychiatric symptoms. This review summarizes the basic mechanisms of COVID-19 pneumonia, psychiatric symptoms following coronavirus infections, effects of ginseng on depression, restlessness, and other psychiatric symptoms associated with post-COVID syn-dromes, as well as possible mechanisms underlying these effects.

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Section: Effects Of Ginseng On Covid-19 Pandemic Caused Depressionmentioning

confidence: 99%