Panax notoginseng saponins inhibits atherosclerotic plaque angiogenesis by down-regulating vascular endothelial growth factor and nicotinamide adenine dinucleotide phosphate oxidase subunit 4 expression

Abstract

PNS, which decreases VEGF and NOX4 expression, could alleviate plaque angiogenesis and attenuate atherosclerosis.

Protective Role of Panax Notoginseng Saponins in Hydrocortisone-Induced Injury in HBMECs by Promoting APOA1 Expression

“…Similar results reported that total PNS promotes angiogenesis deriving from rat bone marrow mesenchymal stem cells (34). By contrast, PNS suppresses angiogenesis of atherosclerotic plaque by decreasing vascular endothelial growth factors and the expression of nicotinamide adenine dinucleotide phosphate oxidase subunit 4 (35).…”

The Effect of Rice Bran Extract on Arterial Blood Pressure, Hepatic Steatosis, and Inflammation in Mice Fed with a High-Fat Diet

“…The amplification efficiency of each primer set was quantified to indicate the accuracy and reliability of this analyzing method. The PCR primers used for gene expression analysis [ 30 , 31 ] are shown in Table 1 .…”

Panax notoginseng Promotes Repair of Colonic Microvascular Injury in Sprague‐Dawley Rats with Experimental Colitis

“…However, the effect of PN on regulating the angiogenesis is still controversial. Qiao et al found that PN extract could inhibit angiogenesis of atherosclerotic plaque by downregulating VEGF [ 20 ]. On the contrary, Yang et al found PN had the effects of proangiogenesis and antiapoptosis [ 21 ].…”