Panax notoginseng saponins radiosensitize colorectal cancer cells by regulating the SNHG6/miR-137 axis

Xu, Caihui; Li, Teng; Liu, Haiyan; Chen, Gongbin; Guo, Yinmou

doi:10.1039/c9ra07622k

Cited by 5 publications

(1 citation statement)

References 34 publications

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“…Several studies on P. notoginseng have concluded that this plant increased the sensitivity of cancer cells to radiation or chemical therapies, so it could be used in combination with these in the treatment of cancer patients. [7][8][9] According to ancient oriental documents, P. notoginseng could decrease the growth of tumors in cancer. According to clinical experience, many patients with fibroids such as in the breast, uterus, and prostate have been treated with P. notoginseng ventricular long-term doses, and the results have found that the tumor sizes were not greatly increased.…”

Section: Introductionmentioning

confidence: 99%

Antitumor Effects of Ethanol Extract from Raw and Steaming Vietnamese Panax notoginseng Roots on Sarcoma 180 Tumor-Bearing Mice

2021

TJNPR

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In addition, water extracted from P. notoginseng has been confirmed to inhibit human lung carcinoma cells, with the inhibition rate reaching 89%. 13 Several studies have shown that steaming P. notoginseng roots increased the antitumor activity. [14][15][16][17] In Vietnam, P. notoginseng grows wildly and is also grown in the high mountains in the north. However, research to evaluate the effect on tumors of raw or steamed P. notoginseng roots is lacking. The study evaluated and compared the antitumor effects of saponin-rich extracts from steamed and raw P. notoginseng roots collected in Vietnam on Swiss mice bearing solid sarcoma TG 180 tumors. Materials and methods Plant materialThe roots used were from 4-year-old tuberous P. notoginseng (Burk.) F.H. grown in Simacai village, Lao Cai province, in the north of Vietnam. The roots were collected in July 2015 and indentified by Dr.

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Section: Introductionmentioning

confidence: 99%

Antitumor Effects of Ethanol Extract from Raw and Steaming Vietnamese Panax notoginseng Roots on Sarcoma 180 Tumor-Bearing Mice

2021

TJNPR

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Panax notoginseng Saponins Ameliorate Gamma Radiation‐Mediated Damages in Human Peripheral Blood Monocytes and Swiss Albino Mice

Yang,

Zhao

2024

Cell Biochemistry & Function

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In this study, the protective effects of Panax notoginseng saponins (PNS) against gamma radiation‐induced DNA damage and associated physiological alterations in Swiss albino mice were investigated. Exposure to gamma radiation led to a dose‐dependent increase in cytokinesis‐blocked micronuclei (CBMN) double‐strand DNA breaks (DSBs), dicentric aberrations (DC), formation in peripheral blood mononuclear cells. However, pretreatment with PNS at concentrations of 1, 5, and 10 µg/mL significantly attenuated the frequencies of DC and CBMN in a concentration‐dependent manner. PNS administration before radiation exposure also reduced radiation‐induced DSBs in BL, indicating protection against reactive oxygen species generation and DNA damage. Notably, pretreatment with PNS at 10 µg/mL prevented the overexpression of γ‐H2AX, proteins associated with DNA damage response, in irradiated mice. In addition, in vivo studies showed intraperitoneal administration of PNS (25 mg/kg body weight) for 1 h before radiation exposure mitigated lipid peroxidation levels and restored antioxidant status, countering oxidative damage induced by gamma radiation. Furthermore, PNS pretreatment reversed the decrease in hemoglobin (Hb) content, white blood cell count, and red blood cell count in irradiated mice, indicating preservation of hematological parameters. Overall, PNS demonstrated an anticlastogenic effect by modulating radiation‐induced DSBs and preventing oxidative damage, thus highlighting its potential as a protective agent against radiation‐induced DNA damage and associated physiological alterations. Clinically, PNS will be beneficial for cancer patients undergoing radiotherapy, but their pharmacological properties and toxicity profiles need to be studied.

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Long non-coding RNAs - SNHG6 emerge as potential marker in colorectal cancer

Jurkiewicz,

Szczepaniak,

Zielińska

2024

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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Panax notoginseng saponins radiosensitize colorectal cancer cells by regulating the SNHG6/miR-137 axis

Abstract: Panax notoginseng saponins (PNS) have recently attracted great attention for their anti-cancer activity in colorectal cancer (CRC).

Cited by 5 publications

References 34 publications

Antitumor Effects of Ethanol Extract from Raw and Steaming Vietnamese Panax notoginseng Roots on Sarcoma 180 Tumor-Bearing Mice

Antitumor Effects of Ethanol Extract from Raw and Steaming Vietnamese Panax notoginseng Roots on Sarcoma 180 Tumor-Bearing Mice

Panax notoginseng Saponins Ameliorate Gamma Radiation‐Mediated Damages in Human Peripheral Blood Monocytes and Swiss Albino Mice

Long non-coding RNAs - SNHG6 emerge as potential marker in colorectal cancer

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