pANCA, ASCA, and OmpC Antibodies in Patients with Ankylosing Spondylitis without Inflammatory Bowel Disease

Vries, M.K. de; Horst‐Bruinsma, Irene E. van der; Hoogstraten, Ingrid M.W. van; Bodegraven, Ad A. van; Blomberg, B. Mary E. von; Ratnawati, Hana; Dijkmans, Ben A. C.

doi:10.3899/jrheum.100269

Cited by 39 publications

(16 citation statements)

References 24 publications

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“…Disease localization was documented according to the Vienna classi cation [12]. All serum samples were obtained before anti-TNFα therapy was initiated [13]. All patients were treated with standard rst line immunosuppressive drugs.…”

Section: Crohn᾽s Disease and Uc Patientsmentioning

confidence: 99%

Increased IgA Glycoprotein-2 Specic Antibody Titres in Refractory Celiac Disease

Groß

Bakker

Bodegraven

et al. 2014

JGLD

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Background & Aims: In most cases celiac disease (CD) is successfully treated with a gluten-free diet (GFD). However, some patients become refractory to the GFD. Refractory CD (RCD) patients have an increased risk for developing enteropathy associated T-cell lymphoma and early diagnosis is therefore of importance. Currently, RCD diagnosis relies on endoscopy and adequate serological markers are lacking. Antibodies against glycoprotein-2 (GP2A) were described in Crohn's disease (CrD) and active CD but not in ulcerative colitis (UC), suggesting this is a specific marker for small intestinal lesions.Methods: Sera obtained from patients visiting our outpatient clinic for routine serological tests for diagnosis and/or follow-up of inflammatory bowel disease (n=78), active CD (n=45), GFD (n=34) and RCD (n=15) were analysed for GP2A titres.Results: Increased GP2A-IgA levels in CrD and active CD as compared to controls (p<0.001) and lack thereof in UC was confirmed. However, we could not confirm the association with small bowel localization within the CrD patient group. Within CD patients, we demonstrated a significant decrease of GP2A-IgA titres upon a GFD and increased levels in RCD patients as compared to patients on a GFD. Although GP2A-IgA was not associated with the degree of villous atrophy, GP2A-IgA levels were able to distinguish RCD patients from GFD patients (ROC AUC=0.79, p=0.002).Conclusion: Follow-up of GP2A-IgA titres in CD patients on a GFD may help to identify patients at risk for developing RCD.Abbreviations: ABSA: anti-bovine serum albumine; ASCA: anti- Saccharomyces cerevisiae antigen; AU:artificial units; AUC: area under the curve; CD: celiac disease; CrD: Crohn's disease; EATL: enteropathyassociated T-cell lymphoma; EmA: anti-endomysium antibodies; GFD: gluten free diet; GP2A: glycoprotein 2 antibodies; IEL: intraepithelial lymphocytes; RCD: refractory celiac disease; ROC: receiver operator curve; TG2A: transglutaminase-2 antibodies; UC: ulcerative colitis.

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Section: Crohn᾽s Disease and Uc Patientsmentioning

confidence: 99%

Increased IgA Glycoprotein-2 Specic Antibody Titres in Refractory Celiac Disease

Groß

Bakker

Bodegraven

et al. 2014

JGLD

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“…ANCA positivity in patients with AS has been reported by several researchers, with 0-28% of AS patients exhibiting ANCA positivity (7)(8)(9)(10). In these reports, the ANCApositive AS patients showed no symptoms of vasculitis or pulmonary manifestations.…”

Section: Discussionmentioning

confidence: 47%

Diffuse Alveolar Hemorrhage in a Patient with Ankylosing Spondylitis

et al. 2013

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Ankylosing spondylitis (AS) primarily affects the spine and axial skeleton. Various pulmonary manifestations have been reported; however, diffuse alveolar hemorrhage (DAH) has not been previously described in a patient with AS. A 49-year-old man with longstanding AS visited our hospital complaining of progressive dyspnea and hemoptysis. DAH was diagnosed based on the findings of chest computed tomography and bronchoscopy. No positive findings suggested any cause of DAH other than weakly positive results for perinuclear antineutrophil cytoplasmic antibodies on indirect immunofluorescence. Following the administration of steroid and plasmapheresis therapy, the patient's symptoms and chest radiographic findings improved. Further clinical case reports and investigations are needed to clarify whether DAH represents a possible pulmonary manifestation of AS.

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“…These include ASCA, ANCA, anti-I2, anti-OmpC and anti-CBir1 antibodies 20. In prior studies from our group examining biomarkers of intestinal inflammation in AS subjects without clinical evidence of IBD, median anti-I2 response was greater in patients with AS, and abnormal faecal calprotectin levels were observed at a significantly higher frequency 9 16.…”

Section: Discussionmentioning

confidence: 97%

Relationship between the gut and the spine: a pilot study of first-degree relatives of patients with ankylosing spondylitis

Kehl

Learch

et al. 2017

RMD Open

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pANCA, ASCA, and OmpC Antibodies in Patients with Ankylosing Spondylitis without Inflammatory Bowel Disease

Cited by 39 publications

References 24 publications

Increased IgA Glycoprotein-2 Specic Antibody Titres in Refractory Celiac Disease

Increased IgA Glycoprotein-2 Specic Antibody Titres in Refractory Celiac Disease

Diffuse Alveolar Hemorrhage in a Patient with Ankylosing Spondylitis

Relationship between the gut and the spine: a pilot study of first-degree relatives of patients with ankylosing spondylitis

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