PanCanSurvPlot: A Large-scale Pan-cancer Survival Analysis Web Application

Abstract

The identification of reliable tumor prognostic markers can help clinicians and researchers predict tumor development and patient survival outcomes more accurately, which plays a vital role in clinical diagnosis, treatment effectiveness assessment, and prognostic evaluation. Existing web tools supporting online survival analysis are gradually failing to meet the increasing demands of researchers in terms of the dataset size, richness of survival analysis methods, and diversity of customization features. Therefore, there is an urgent need for a large-scale, one-stop pan-cancer survival analysis web server. We developed PanCanSurvPlot (https://smuonco.shinyapps.io/PanCanSurvPlot/), a Shiny web tool that has incorporated a total of 215 cancer-related datasets from the GEO and TCGA databases, covering nearly 100,000 genes (mRNAs, miRNAs, and lncRNAs), approximately 45,000 samples, 51 different cancer types, and 13 different survival outcomes. The website also provides two cutoff methods based on median and optimal cutpoints. All survival analysis results from the log-rank test and univariate Cox regression are presented in a clear and straightforward summary table. Finally, users can customize color schemes and cutpoint levels to quickly obtain high-quality Kaplan–Meier survival plots that meet publication requirements.

TSPAN6 reinforces the malignant progression of glioblastoma via interacting with CDK5RAP3 and regulating STAT3 signaling pathway

“…In addition, the mRNA and protein levels of CDK5RAP3 were overexpressed in glioblastoma clinical samples compared with normal tissues (Figure 6 D and 6 E) 24 . The overexpression of CDK5RAP3 was corelated with poor overall survival of glioblastoma patients (Figure 6 F) 25 . Furthermore, CDK5RAP3 knockdown successfully reversed the enhanced migrative and invasive abilities induced by TSPAN6 overexpression in glioblastoma cells (Figure 6 G and 6 H, Figure S4 B).…”

HSPB8 Facilitates the Oncogenesis and Advancement of Bladder Cancer via Activation of HSP27

“…Similarly, higher clinical stages of bladder cancer also displayed augmented HSPB8 expression (Figure 1 D). To explore the potential impact of HSPB8 on the prognosis of bladder cancer patients, we utilized the PanCanSurvPlot 9 online tool to conduct survival analyses on tissue samples from both TCGA and GEO databases. The findings revealed that patients with high HSPB8 expression in the TCGA database had a significantly lower overall survival rate ( P < 0.05) and disease-specific survival ( P < 0.05).…”

Integrated transcriptome, proteome and single‐cell sequencing uncover the prognostic and immunological features of colony‐stimulating factor 3 receptor in pan‐cancer

“…We used the PanCanSurvPlot 16 (https://smuonco.shinyapps.io/PanCanSurvPlot/) to obtain the survival plots of CSF3R in cancer patients, including overall survival (OS) and disease‐specific survival (DSS).…”

“…PanCanSurvPlot 16 Survival plots of CSF3R in cancer patients cBioPortal 17,18 Genetic alterations of CSF3R and the survival significance in cancer patients…”