Pancreas divisum as a predisposing factor for chronic and recurrent idiopathic pancreatitis: initial in vivo survey

Gonoi, Wataru; Akai, Hiromu; Hagiwara, Kazuchika; Akahane, Masaaki; Hayashi, Naoto; Maeda, Eriko; Yoshikawa, Tsuneo; Tada, Minoru; Uno, Kansei; Ohtsu, Hiroshi; Koike, Kazuhiko; Ohtomo, Kuni

doi:10.1136/gut.2010.230011

Cited by 80 publications

(41 citation statements)

References 25 publications

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“…PD was present in 35% of patients with pancreatitis versus 2.6% in the general community and had an odds ratio of 23.4 for inducing pancreatitis. 44 However, recent studies have shown an association of genetic mutations and PD in patients with IRAP. We have shown that SPINK1 (pancreatic secretory trypsin inhibitor) gene mutations were present in 40% of patients with IRAP and PD.…”

Section: Pancreas Divisum (Pd)mentioning

confidence: 99%

Recurrent acute pancreatitis: an approach to diagnosis and management

Kedia¹,

Dhingra²,

Garg³

2013

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Recurrent acute pancreatitis (RAP) is defined as more than two attacks of acute pancreatitis (AP) without any evidence of underlying chronic pancreatitis (CP). As the known causes of AP are generally taken care of, RAP usually occurs in the idiopathic group, which forms 20%- In general, empirical cholecystectomy should be discouraged with the availability and widespread use of EUS. Endoscopic sphincterotomy is advised if there is strong suspicion of SOD. Minor papilla sphincterotomy should be carried out in those with PD but with limited expectations. Regular follow-up of patients with IRAP is necessary because most patients are likely to develop CP in due course.

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Section: Pancreas Divisum (Pd)mentioning

confidence: 99%

Recurrent acute pancreatitis: an approach to diagnosis and management

Kedia¹,

Dhingra²,

Garg³

2013

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“…MRCP allows for non-invasive assessment of the distal CBD and pancreatic duct (PD) to detect for ductal dilatation, IDE and anatomical variants such as pancreas divisum which has a prevalence of between 1.5% and 6% 9 (in which case attempts at post resection PD stenting may prove frustratingly futile!). Its accuracy is reported at 81% 3 , though this is in the hands of expert pancreatico-biliary radiologists.…”

Section: Lesion Assessment and Stagingmentioning

confidence: 99%

Endoscopic ampullectomy: A practical guide

Bassan¹,

Bourke²

2012

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Abbreviations: CBD: common bile duct; ERCP: endoscopic retrograde cholangio-pancreatography; EUS: endoscopic ultrasound; IDE: intraductal extension; LST-P: laterally spreading tumor of the papilla; MRCP: magnetic resonance cholangiopancreatography; PD: pancreatic ductEndoscopic ampullectomy is a minimally invasive method of treating superficial lesions of the ampulla of Vater. With careful patient selection and lesion assessment it is a safe and efficacious therapeutic procedure that can obviate the need for potentially major surgical intervention. Strategies for safe and successful endoscopic ampullectomy with a focus on resection technique and recognition and management of complications are presented.

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“…It described their association with idiopathic pancreatitis, concluding that pancreas divisum should be considered as predisposing factor to recurring pancreatitis [34].…”

Section: Pancreas Divisummentioning

confidence: 99%

“…In pancreas divisum normal fusion fails to occur: the dorsal duct drains most of the pancreas through the minor papilla and the ventral duct drains only the head of the pancreas through the major papilla. Pancreas divisum is diagnosed by pancreatography either by ERCP or MRCP [18,33,34].…”

Section: Pancreas Divisummentioning

confidence: 99%

Etiology of acute pancreatitis

2014

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AbstractAcute pancreatitis is a common disease with a benign course in the majority of patients, but it is associated with serious morbidity, and mortality close to 20% in up to 20% of cases. The incidence of acute pancreatitis seems to be rising in western countries. About 75% of all cases are caused by gallstones or alcoholism. The relative rate of gallstones versus alcohol as etiology depends on the age and the area of enrolment. A thorough evaluation allows cause identification in another 10% of cases, leaving about 15–20% as idiopathic. The most common causes, and a growing list of less frequent and sometimes very rare and controversial etiologies, are reviewed in this article. A classification on the pathogenic mechanisms of causes of acute pancreatitis based is used in this Review. The approach, or suggested plan of investigations, to determine the etiology of acute pancreatitis, based on the most recently published Guidelines is outlined.

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Pancreas divisum as a predisposing factor for chronic and recurrent idiopathic pancreatitis: initial in vivo survey

Cited by 80 publications

References 25 publications

Recurrent acute pancreatitis: an approach to diagnosis and management

Recurrent acute pancreatitis: an approach to diagnosis and management

Endoscopic ampullectomy: A practical guide

Etiology of acute pancreatitis

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