Pancreas: Healing response in critical illness

Bentrem, David J.; Joehl, Raymond J.

doi:10.1097/01.ccm.0000081428.35729.73

Cited by 33 publications

(24 citation statements)

References 91 publications

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“…Excessive inflammatory reaction plays a vital role in SAP pathogenesis [3][4][5][6] . In this experiment, the influence of dexamethasone on inflammator y mediators in treatment of SAP rats was studied and its relationship with the apoptosis of pancreatic acinar cells was discussed.…”

Section: Discussionmentioning

confidence: 99%

Effects of large dose of dexamethasone on inflammatory mediators and pancreatic cell apoptosis of rats with severe acute pancreatitis

Zhang

Chen²,

Hu³

et al. 2007

WJG

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AIM:To investigate the influence of high dose of dexamethasone on inflammatory mediators and apoptosis of rats with severe acute pancreatitis (SAP).METHODS: SAP rats were randomly assigned to the model group and treatment group while the normal rats were assigned to the sham operation group. The mortality, ascite volumes, ascites/body weight ratio and pancreas pathological changes of all rats were observed at 3, 6 and 12 h after operation. Their contents of amylase and endotoxin in plasma and contents of tumor necrosis factor (TNF-α), phospholipase A2 (PLA2) and IL-6 in serum were also determined. The microarray sections of their pancreatic tissues were prepared, terminal transferase dUTP nick end labeling (TUNEL) staining was performed and apoptotic indexes were calculated. RESULTS:There was no marked difference between treatment group and model group in survival. The contents of amylase and endotoxin in plasma and contents of TNF-α, PLA2 and IL-6 in serum, ascite volumes, ascites/body weight ratio and pancreas pathological scores were all lower in treatment group than in model group to different extents at different time

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Section: Discussionmentioning

confidence: 99%

Effects of large dose of dexamethasone on inflammatory mediators and pancreatic cell apoptosis of rats with severe acute pancreatitis

Zhang

Chen²,

Hu³

et al. 2007

WJG

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“…Following damage, pathologic processes that occur in the pancreas include interstitial edema, necrosis of parenchymal cells, intrapancreatic trypsin activation, inflammatory cell infiltration, and activation and proliferation of PaSCs. In human and rodent pancreatic tissues, activated PaSCs are usually found in areas of extensive necrosis and inflammation where an environment rich in cytokines, growth factors, and reactive oxygen species prevails (56)(57)(58). Time-course studies using several animal models of experimental pancreatitis (59)(60)(61) indicate that parenchymal necrosis and inflammation precede PaSC activation, thereby suggesting that a necrotic, inflammatory process is a prerequisite for activation of these cells.…”

Section: Pascs and Pancreatic Inflammationmentioning

confidence: 99%

The pancreatic stellate cell: a star on the rise in pancreatic diseases

Omary¹,

Lugea²,

Lowe³

et al. 2007

J. Clin. Invest.

612

614

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“…Accordingly, death in the first week after onset of acute pancreatitis is mainly due to SIRS accompanied by MOF. In mild cases, however, mild or moderate SIRS may occur and is presumed to be beneficial [64]. …”

Section: Acute Pancreatitis As a Working Modelmentioning

confidence: 99%

Prevention of Infectious Complications in Surgical Patients: Potential Role of Probiotics

Besselink

Timmerman²,

Minnen³

et al. 2005

Dig Surg

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Infectious complications in surgical patients often originate from the intestinal microflora. In the critically ill patient, small bowel motility is disturbed, leading to bacterial overgrowth and subsequent bacterial translocation due to dysfunction of the gut mucosal barrier. The optimal prophylactic strategy should act on all these factors, but such a strategy is not yet available. For several decades, antibiotic prophylaxis to prevent translocation of pathogenic bacteria has been studied with conflicting results. Selective decontamination of the digestive tract has shown good results, but fear for bacterial multiresistance has prevented worldwide implementation. In recent years, probiotics, living bacteria with a potential beneficial effect to their host, have shown promising results in several randomized placebo-controlled trials. Currently, in vitro and experimental research focuses on the effects of probiotics on the microflora responsible for gut-derived infections, structural mucosal barrier function and the immune system.

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Pancreas: Healing response in critical illness

Cited by 33 publications

References 91 publications

Effects of large dose of dexamethasone on inflammatory mediators and pancreatic cell apoptosis of rats with severe acute pancreatitis

Effects of large dose of dexamethasone on inflammatory mediators and pancreatic cell apoptosis of rats with severe acute pancreatitis

The pancreatic stellate cell: a star on the rise in pancreatic diseases

Prevention of Infectious Complications in Surgical Patients: Potential Role of Probiotics

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