Pancreas Transplantation Prevents Morphologic and Ultrastructural Changes in Pulmonary Parenchyma of Alloxan-Induced Diabetic Rats

Spadella, César Tadeu; Suarez, Olivia Adayr Xavier; Lucchesi, Amanda Natália; Catâneo, Antônio José Maria

doi:10.1016/j.transproceed.2010.05.112

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…Assessment of the morphological characteristics of lung tissue showed that diabetic animals exhibited different pulmonary structure when compared to healthy rats. Increase in bronchovascular wall thickening, presence of inflammatory infiltrate and pulmonary edema were some of the anatomopathological findings, corroborating other studies (Goldman, 2003;Eren et al, 2010;Spadella et al, 2010;Hagiwara et al, 2011). These investigations also demonstrated morphofunctional alterations in the lung tissue of diabetic rats.…”

Section: Discussionsupporting

confidence: 90%

Ethanol extract of Cissampelos sympodialis ameliorates lung tissue damage in streptozotocin-induced diabetic rats

Medeiros

Pereira

Silva

et al. 2020

Braz. J. Pharm. Sci.

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Section: Discussionsupporting

confidence: 90%

Ethanol extract of Cissampelos sympodialis ameliorates lung tissue damage in streptozotocin-induced diabetic rats

Medeiros

Pereira

Silva

et al. 2020

Braz. J. Pharm. Sci.

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“…Several studies conducted in our laboratory have previously shown that PT is not only able to restore the endocrine balance in ALX-induced diabetic rats but can also prevent or stabilize the progression of diabetic lesions in the kidneys, eyes, nerves and lungs of these animals [45][46][47][48]. These findings have been confirmed by others in humans [4][5][6][7].…”

Section: Discussionsupporting

confidence: 68%

Pancreas Transplantation Delays the Progression of Morphological, Morphometric and Ultrastructural Changes in Testes of Alloxan-Induced Diabetic Rats

Spadella

Trindade

Lucchesi

et al. 2017

Exp Clin Endocrinol Diabetes

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The aim of this study was to assess the effects of pancreas transplantation on the progression of testicular lesions in diabetic rats. Diabetic rats were subjected to pancreas transplantation and sacrificed after 6, 14, 26 and 50 weeks of follow-up, using non-diabetic and untreated diabetic rats as controls. Successful pancreas transplantation corrected all of the metabolic changes observed in diabetic rats, including low levels of testosterone. The testicular mass was decreased, and the relative weight of the testes was high in diabetic rats. The seminiferous tubules of diabetic rats showed progressive atrophy of the germinal epithelium, with cytoplasmic vacuolization, detachment of germ cells to the tubular lumen and the appearance of giant cells. Leydig cells were abnormally distributed, and hyperplasia of Sertoli cells was observed. Sperm were not detectable within the tubular lumen in late follow-up. The diameter, total area, lumen area, and germinal epithelium area of the seminiferous tubules were low, and tubular density was high in diabetic rats. Ultrastructural changes were also observed in these rats, compromising the cytoplasm, organelles and cellular nuclei of the germ, Sertoli, and Leydig cells. The most frequent changes consisted of accumulation of lipid droplets and electron-dense dark material in the cell cytoplasm, cellular degeneration and apoptosis. Similar to non-diabetic rats, pancreas-transplanted rats showed progressive testicular lesions, but they were much less severe and occurred much later than in the untreated diabetic controls. Diabetes causes morphological and ultrastructural changes in rat testes, but the progression of lesions can be significantly delayed by successful pancreas transplantation, which may have a positive impact on male infertility due to diabetes.

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Rodent Models for Metabolic Syndrome Research

Panchal

Brown

2010

BioMed Research International

319

257

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Rodents are widely used to mimic human diseases to improve understanding of the causes and progression of disease symptoms and to test potential therapeutic interventions. Chronic diseases such as obesity, diabetes and hypertension, together known as the metabolic syndrome, are causing increasing morbidity and mortality. To control these diseases, research in rodent models that closely mimic the changes in humans is essential. This review will examine the adequacy of the many rodent models of metabolic syndrome to mimic the causes and progression of the disease in humans. The primary criterion will be whether a rodent model initiates all of the signs, especially obesity, diabetes, hypertension and dysfunction of the heart, blood vessels, liver and kidney, primarily by diet since these are the diet-induced signs in humans with metabolic syndrome. We conclude that the model that comes closest to fulfilling this criterion is the high carbohydrate, high fat-fed male rodent.

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Pancreas Transplantation Prevents Morphologic and Ultrastructural Changes in Pulmonary Parenchyma of Alloxan-Induced Diabetic Rats

Abstract: We conclude that PT can control morphologic and ultrastructural changes in pulmonary parenchyma, suggesting a promising perspective for preventing other chronic diabetic lesions.

Cited by 4 publications

References 17 publications

Ethanol extract of Cissampelos sympodialis ameliorates lung tissue damage in streptozotocin-induced diabetic rats

Ethanol extract of Cissampelos sympodialis ameliorates lung tissue damage in streptozotocin-induced diabetic rats

Pancreas Transplantation Delays the Progression of Morphological, Morphometric and Ultrastructural Changes in Testes of Alloxan-Induced Diabetic Rats

Rodent Models for Metabolic Syndrome Research

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