Pancreatic abscess: A review of seventeen cases

Vohra, Rohit; Verma, Geetika; Kaushik, Sushmita; Sabharwal, Atika

doi:10.1002/bjs.1800710221

Cited by 23 publications

(7 citation statements)

References 4 publications

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“…On the other hand, there is a substantial record of the benefit of antibiotic administration before (19), during (30), and after (32) drainage. Moreover, abscesses of different locations and origins have been efficiently cured with systemic anti-infective chemotherapy alone (12,23,29,35).…”

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confidence: 99%

Antibiotic Abscess Penetration: Fosfomycin Levels Measured in Pus and Simulated Concentration-Time Profiles

Sauermann

Karch²,

Langenberger³

et al. 2005

Antimicrob Agents Chemother

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The present study was performed to evaluate the ability of fosfomycin, a broad-spectrum antibiotic, to penetrate into abscess fluid. Twelve patients scheduled for surgical or computer tomography-guided abscess drainage received a single intravenous dose of 8 g of fosfomycin. The fosfomycin concentrations in plasma over time and in pus upon drainage were determined. A pharmacokinetic model was developed to estimate the concentration-time profile of fosfomycin in pus. Individual fosfomycin concentrations in abscess fluid at drainage varied substantially, ranging from below the limit of detection up to 168 mg/liter. The fosfomycin concentrations in pus of the study population correlated neither with plasma levels nor with the individual ratios of abscess surface area to volume. This finding was attributed to highly variable abscess permeability. The average concentration in pus was calculated to be 182 ؎ 64 mg/liter at steady state, exceeding the MIC 50/90 s of several bacterial species which are commonly involved in abscess formation, such as streptococci, staphylococci, and Escherichia coli. Hereby, the exceptionally long mean half-life of fosfomycin of 32 ؎ 39 h in abscess fluid may favor its antimicrobial effect because fosfomycin exerts time-dependent killing. After an initial loading dose of 10 to 12 g, fosfomycin should be administered at doses of 8 g three times per day to reach sufficient concentrations in abscess fluid and plasma. Applying this dosing regimen, fosfomycin levels in abscess fluid are expected to be effective after multiple doses in most patients.

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confidence: 99%

Antibiotic Abscess Penetration: Fosfomycin Levels Measured in Pus and Simulated Concentration-Time Profiles

Sauermann

Karch²,

Langenberger³

et al. 2005

Antimicrob Agents Chemother

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“…[24][25][26][27] Effective treatment involves drainage of the abscess followed by appropriate antibiotic therapy. Many of the patients in past reports were immunosuppressed to some degree, and all had received antibiotic therapy, which increases the risk of serious candidal infection in very ill patients.…”

Section: Discussionmentioning

confidence: 99%

Candida albicans -Infected Pancreatic Pseudocyst: Report of a Case

2004

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“…Kaushik et al . reported a range of 3−60 days 12 . Warshaw and Jin reported a mean duration of 32 days, with 26 (58%) of 45 patients presenting within 2 weeks of onset of pancreatitis 4 .…”

Section: Discussionmentioning

confidence: 99%

“…Kaushik et al . reported a mortality of 60% managed by surgery 12 . Warshaw and Jin noted an improvement in mortality in patients with pancreatic abscess accounted for by an increase in the experience of the treating centre managing this particular problem, meticulous surgical technique and early recognition of postoperative complications 4 .…”

Section: Discussionmentioning

confidence: 99%