Pancreatic acinar cell carcinoma—case report and literature review

Zhang, Xingmao; Zhang, Hongjuan; He, Qiang

doi:10.1186/s12885-018-5008-z

Cited by 12 publications

(7 citation statements)

References 18 publications

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“…[3] NETs usually show strong enhancement on postcontrast images and malignant IPMN is associated with dilatation of main pancreatic duct; both of these findings were absent in this case. Rare primary tumors associated with calcification include acinar cell carcinoma, [4] liposarcoma, and chondrosarcoma. [5] Some case reports have described psammomatous calcification within the primary adenocarcinoma of the pancreas.…”

Section: Review Of Literaturementioning

confidence: 99%

Pancreatic Adenocarcinoma with Primary Tumor Calcification and Calcified Liver Metastasis: Report of a Rare Case and Review of Literature

Ghosh

Ganguly

Dabkara

et al. 2020

Indian Journal of Medical and Paediatric Oncology

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Calcification is a feature of benign pancreatic diseases such as chronic calcific pancreatitis (CCP) or benign pancreatic tumors such as solid and papillary epithelial neoplasm of the pancreas and serous cystadenoma. The presence of calcification in a primary malignant pancreatic tumor is uncommon except for neuroendocrine tumors of the pancreas. Calcification in adenocarcinoma of the pancreas involving the primary tumor as well as the metastasis resulting thereof is extremely rare in the absence of CCP. To our knowledge, this is the first report of a case of primary adenocarcinoma of the pancreas that presented with calcification of the primary tumor as well as the metastatic liver nodules, accompanied by hypercalcemia.

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Section: Review Of Literaturementioning

confidence: 99%

Pancreatic Adenocarcinoma with Primary Tumor Calcification and Calcified Liver Metastasis: Report of a Rare Case and Review of Literature

Ghosh

Ganguly

Dabkara

et al. 2020

Indian Journal of Medical and Paediatric Oncology

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“…Acinar cell carcinoma (ACC) is a rare pancreatic epithelial malignancy derived mainly from pancreatic acinar cells and terminal branches of the pancreatic duct, accounting for approximately 1% of all pancreatic tumors ( 1 ). The hallmark pathological feature of ACC is its exocrine function and its potent capacity to invade and metastasize ( 2 ), which makes treatment of ACC more difficult than that of other pancreatic tumors and leads to an extremely pessimistic prognosis ( 3 ). The 5-year mortality rate of patients with ACC exceeds 50%, and its lethality ranks among the highest among all malignancies ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Imaging and Clinicopathological Features of Acinar Cell Carcinoma

Xin

et al. 2022

Front. Oncol.

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BackgroundAcinar cell carcinoma (ACC) is a rare pancreatic epithelial malignancy that poses a significant threat. However, there are few related clinical studies. The present study aimed to analyze the imaging and pathological features of ACC to provide a reference for better diagnosis and treatment planning.MethodsThirty-nine with ACC, referred to Qianfoshan Hospital, Qilu Hospital and Provincial Hospital in Shandong Province from December 2012 to December 2020, were enrolled. Their imaging and clinicopathological features were analyzed. They were followed up for 1 year, and Cox regression was used to analyze the factors affecting patient prognosis.ResultsACC was more common in the middle-aged and elderly and peaked at approximately 60 years. The clinical manifestations of the patients were mostly flatulence and upper abdomen pain. The tumor was located in the head of the pancreas in 19 cases, with an average size of 5.8 cm. We found nerve invasion and liver metastasis in one case each. 8 patients showed irregular amorphous tumor calcification on plain computed tomography and 5 showed high and low signals on T1- and T2-weighted images, respectively. Immunohistochemistry revealed 100.0% positive rates for CK, β-catenin, and Ki-67. Thirty-three patients underwent surgical resection, and the 2-year overall mortality rate was 25.6%. Cox analysis revealed that smoking was an independent risk factor affecting patient prognosis.ConclusionAn in-depth understanding of the imaging and clinicopathological features of ACC is conducive to better diagnosis and treatment planning for ACC and subsequent improvement in patient prognosis.

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“…Nevertheless, most malignant tumors originating from the exocrine pancreas are pancreatic ductal adenocarcinoma (PDAC), with pancreatic acinar cell carcinoma (PACC) accounting for less than 1% of primary pancreatic neoplasms [2][3][4]. Because of the rarity of PACC, it is difficult to know the exact characteristics of this disease and clinical course, as most studies reported to date only have limited numbers with data from single-center studies or multicenter studies [5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics of Resected Acinar Cell Carcinoma of the Pancreas: A Korean Multi-Institutional Study

Shin

Hwang

Jang

et al. 2021

Cancers

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Given the rare incidence of pancreatic acinar cell carcinoma (PACC), its post-resection clinical outcomes remain unclear. Treatment strategies for PACC have relied on those of pancreatic ductal adenocarcinoma (PDAC). The present study retrospectively investigated clinicopathologic characteristics of resected PACC registered in the Korea Tumor Registry System Biliary Pancreas database. Among 59 patients with a mean age of 59.2 years and a male predominance (83.1%), 43, 5, 7, and 4 had pure PACC, ductal differentiations, mixed neuroendocrine carcinomas, and intraductal and papillary variants, respectively. The mean tumor size was 4.6 cm, consisting of eight at T1, 26 at T2, and 25 at T3 stages. Metastasis to regional lymph node was identified in 15 (25.4%) patients. Thirty-one (52.5%) patients received adjuvant therapy. Five-year survival rate was 57.4%. The median survival was 78.8 months. In survival comparison according to the stage with AJCC system, N stage (lymph node metastasis), but not T stage, showed significant differences (p = 0.027). Resected PACC appeared to have clinical outcomes distinct from those of PDAC in this nationwide study. Therefore, large-scale multinational studies are needed to overcome the rarity of PACC and to establish an appropriate treatment strategies and staging system.

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Pancreatic acinar cell carcinoma—case report and literature review

Cited by 12 publications

References 18 publications

Pancreatic Adenocarcinoma with Primary Tumor Calcification and Calcified Liver Metastasis: Report of a Rare Case and Review of Literature

Pancreatic Adenocarcinoma with Primary Tumor Calcification and Calcified Liver Metastasis: Report of a Rare Case and Review of Literature

Imaging and Clinicopathological Features of Acinar Cell Carcinoma

Clinical Characteristics of Resected Acinar Cell Carcinoma of the Pancreas: A Korean Multi-Institutional Study

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