Pancreatic Adenocarcinoma

Ryan, David P.; Hong, Theodore S.; Bardeesy, Nabeel

doi:10.1056/nejmra1404198

Cited by 2,010 publications

(1,917 citation statements)

References 73 publications

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“…Worldwide, the incidence of all types of pancreatic cancer (85% of which are PDAC) ranges from 1 to 10 cases per 100, 000 people (Ryan et al, 2014), Accounted for 2% of all malignant tumor incidence in china. At present, The 5-year survival rate of PDAC was only 3-5%, was the lowest in all cancers.…”

Section: Introductionmentioning

confidence: 99%

Annexin A2 and CD105 Expression in Pancreatic Ductal Adenocarcinoma is Associated with Tumor Recurrence and Prognosis

Huang

Hong²,

Wang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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To investigate the value of expression of annexin A2, microvessel density (MVD) and CD105 in pancreatic ductal adenocarcinoma (PDAC) tissues and adjacent normal tissues, immunohistochemical staining was used. The positive expression rate of Annexin A2 and the MVD in pancreatic ductal adenocarcinoma tissues was higher than that in in adjacent normal tissues (p<0.005). Expression of Annexin A2 and MVD correlated with histological grade (p<0.05). MVD of cancers in TNM stage Ⅱb was higher than that in TNM stageⅠ~Ⅱa (p<0.026). Cancerous tissues with Annexin A2 staining grade 3+ had lower MVD than the tissues with the other Annexin A2 staining grade (p<0.05). Patients with high MVD had worse prognosis. However , our study did not confirm Annexin A2 was an independent risk factor for patients with PDAC. We confirmed MVD labeled by CD105 was an independent risk factor for patients with PDAC and had moderate predictive value of prognosis.

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Section: Introductionmentioning

confidence: 99%

Annexin A2 and CD105 Expression in Pancreatic Ductal Adenocarcinoma is Associated with Tumor Recurrence and Prognosis

Huang

Hong²,

Wang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…About one fifth of pancreatic cancers arise from cystic lesions that can potentially be identified in early, treatable stages with non-invasive imaging techniques such as computed tomography (CT) and magnetic resonance imaging (MRI). Cystic lesions are relatively common, occurring in at least 2% of adults 3 , with some studies describing the incidental finding of pancreatic cysts in more than 10% of abdominal MRIs obtained for non-pancreatic indications 4 . It should therefore come as no surprise that cystic lesions account for one third of all pancreatic surgeries 5 .…”

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confidence: 99%

Light scattering spectroscopy identifies the malignant potential of pancreatic cysts during endoscopy

et al. 2017

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Pancreatic cancers are usually detected at an advanced stage and have poor prognosis. About one fifth of these arise from pancreatic cystic lesions. Yet not all lesions are precancerous, and imaging tools lack adequate accuracy for distinguishing precancerous from benign cysts. Therefore, decisions on surgical resection usually rely on endoscopic ultrasound-guided fine needle aspiration (EUS-FNA). Unfortunately, cyst fluid often contains few cells, and fluid chemical analysis lacks accuracy, resulting in dire consequences, including unnecessary pancreatic surgery for benign cysts and the development of cancer. Here, we report an optical spectroscopic technique, based on a spatial gating fibre-optic probe, that predicts the malignant potential of pancreatic cystic lesions during routine diagnostic EUS-FNA procedures. In a double-blind prospective study in 25 patients, with 14 cysts measured in vivo and 13 postoperatively, the technique achieved an overall accuracy of 95%, with a 95%confidence interval of 78–99%, in cysts with definitive diagnosis.

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“…For patients who do not benefit from surgery the 5-year survival rate is less than 5%. 1 Despite significant scientific advances in our understanding of PDAC pathobiology and extensive efforts to develop new therapeutic tools to tackle this cancer, the survival rate for PDAC patients has not improved significantly over past decades. Many obstacles specific to this tumor, such as late diagnosis, early metastatic spread, and resistance to chemotherapy and radiotherapy, have hampered clinical progress against PDAC.…”

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confidence: 99%

“…Histologically, pancreatic tumors are characterized by a prominent stroma made up of extracellular matrix components, activated cancer-associated fibroblasts, immune cells, nerve fibers, and few and abnormal blood vessels. 1 This stromal architecture creates a physical barrier for drug delivery and for proper diffusion of oxygen and nutrients toward cancer cells. Despite nutrient deprivation and hypoxic stress the tumor cells are proliferating, attesting to their ability to rewire their metabolism in order to cope with adverse environmental conditions and form a tumor mass.…”

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confidence: 99%