Pancreatic Adenocarcinoma: CT and PET/CT

Richter, G. M.

doi:10.1007/978-1-4939-7193-0_90

Cited by 1 publication

(2 citation statements)

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“…Compared to traditional imaging methods, 18 F‐fluorodeoxglucose positron emission tomography/computed tomography ( 18 F FDG PET/CT) imaging has been reported to be particularly helpful in differentiating between AIP and PDAC, especially when biopsy is inconclusive. Functional information obtained by positron emission tomography (PET) can be combined with anatomic information obtained by CT to provide a specific guide for the differentiation of AIP and PDAC.…”

Section: Introductionmentioning

confidence: 99%

“…Functional information obtained by positron emission tomography (PET) can be combined with anatomic information obtained by CT to provide a specific guide for the differentiation of AIP and PDAC. For the last decade, many studies have been conducted to assess the efficacy of 18 F‐FDG PET/CT for the differentiation of AIP and PDAC. However, most of the assessment was based on the visual analysis or thresholding the clinical parameters such as maximum standardized uptake values (SUV max ) and mean retention index (RI).…”

Section: Introductionmentioning

confidence: 99%

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Radiomics analysis for the differentiation of autoimmune pancreatitis and pancreatic ductal adenocarcinoma in ¹⁸F‐FDG PET/CT

et al. 2019

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Purpose To perform a radiomics analysis with comparisons of multidomain features and a variety of feature selection strategies and classifiers, with the goal of evaluating the value of quantified radiomics method for noninvasively differentiating autoimmune pancreatitis (AIP) from pancreatic ductal adenocarcinoma (PDAC) in 18F‐fluorodeoxglucose positron emission tomography/computed tomography (18F FDG PET/CT) images. Methods We extracted 251 expert‐designed features from 2D and 3D PET/CT images of 111 patients, and recombined these features into five feature sets according to their modalities and dimensions. Among the five feature sets, the optimal one was found leveraging four feature selection strategies and four machine learning classifiers based on the area under the receiver operating characteristic curve (AUC). The feature selection strategies include spearman’s rank correlation coefficient, minimum redundancy maximum relevance, support vector machine recursive feature elimination (SVM‐RFE), and no feature selection, while the classifiers are random forest, adaptive boosting, support vector machine (SVM) with the Gaussian radial basis function, and SVM with the linear kernel function respectively. Based on the optimal feature set, these feature selection strategies and classifiers were comparatively studied to achieve the best differentiation. Finally, the quantified radiomics prediction model was developed based on the best combination of the feature selection strategy and classifier, and it was compared with two clinical factors based prediction models, and human doctors using nested cross‐validation in terms of AUC, accuracy, sensitivity, and specificity. Results Comparison experiments demonstrated that CT features and three‐dimensional (3D) features performed better than positron emission tomography (PET) features and three‐dimensional (2D) features respectively, and multidomain features were superior to single domain features. In addition, the combination of SVM‐RFE feature selection strategy and Linear SVM classifier had the highest diagnostic performance (i.e., AUC = 0.93 ± 0.01, ACC = 0.85 ± 0.02, SEN = 0.86 ± 0.03, SPE = 0.84 ± 0.03). The quantified radiomics model developed is significantly superior to both human doctors and clinical factors based prediction models in terms of accuracy and specificity. Conclusions Our preliminary results confirmed that the quantified radiomics method could aid the noninvasive differentiation of AIP and PDAC in 18F FDG PET/CT images and the integration of multidomain features is beneficial for the differentiation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Radiomics analysis for the differentiation of autoimmune pancreatitis and pancreatic ductal adenocarcinoma in ¹⁸F‐FDG PET/CT

et al. 2019

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Pancreatic Adenocarcinoma: CT and PET/CT

Cited by 1 publication

References 76 publications

Radiomics analysis for the differentiation of autoimmune pancreatitis and pancreatic ductal adenocarcinoma in ¹⁸F‐FDG PET/CT

Radiomics analysis for the differentiation of autoimmune pancreatitis and pancreatic ductal adenocarcinoma in ¹⁸F‐FDG PET/CT

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Pancreatic Adenocarcinoma: CT and PET/CT

Cited by 1 publication

References 76 publications

Radiomics analysis for the differentiation of autoimmune pancreatitis and pancreatic ductal adenocarcinoma in 18F‐FDG PET/CT

Radiomics analysis for the differentiation of autoimmune pancreatitis and pancreatic ductal adenocarcinoma in 18F‐FDG PET/CT

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Radiomics analysis for the differentiation of autoimmune pancreatitis and pancreatic ductal adenocarcinoma in ¹⁸F‐FDG PET/CT

Radiomics analysis for the differentiation of autoimmune pancreatitis and pancreatic ductal adenocarcinoma in ¹⁸F‐FDG PET/CT