Pancreatic Adenocarcinoma With Rare Sigmoid Colon Metastasis

Kahl, Ryan; George, Khalid; Patel, Kruti; Stawick, Laurence

doi:10.14309/crj.0000000000000132

Cited by 11 publications

(8 citation statements)

References 13 publications

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“…To the best of our knowledge, only a few cases of synchronous or metachronous colonic metastasis secondary to pancreatic cancer were reported in the literature [2,5]. Therefore, we report a rare and very interesting case of incidental synchronous pancreatic adenocarcinoma with concurrent hepatic and sigmoid colonic metastasis.…”

Section: Introductionmentioning

confidence: 83%

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A Rare Case of Pancreatic Adenocarcinoma With Incidental Synchronous Hepatic and Sigmoid Colonic Metastasis: A Case Report and Literature Review

Alali¹,

Ayesh²,

Fathaddin³

et al. 2022

Cureus

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Metastasis of pancreatic adenocarcinoma to the colon is a very rare condition that might be underdiagnosed and underreported in the literature. We report a very rare case of incidental findings of sigmoid metastasis secondary to pancreatic adenocarcinoma in a 60-year-old Saudi male, who is a non-smoker with a normal medical and surgical history. The patient presented to a primary care clinic with abdominal bloating and vague on/off abdominal pain for almost 1 year as well as unintentional weight loss without lower gastrointestinal (GI) symptoms. After the case was discussed in the multidisciplinary tumor board, the patient was started on systematic palliative chemotherapy. However, after receiving the first cycle, he started to deteriorate rapidly and succumbed to secondary cardiopulmonary arrest. Cases of synchronous metastasis of pancreatic adenocarcinoma to the colon might not be well known or common. However, a high index of suspicion and individualizing the workup tools may need to be used.

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Section: Introductionmentioning

confidence: 83%

“…However, only around 20% have resectable disease at the time of diagnosis. It metastasizes to the liver, lungs, regional lymph nodes, or peritoneum, but very rarely to the colon or the sigmoid [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Pancreatic Adenocarcinoma With Incidental Synchronous Hepatic and Sigmoid Colonic Metastasis: A Case Report and Literature Review

Alali¹,

Ayesh²,

Fathaddin³

et al. 2022

Cureus

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“…Pancreatic cancer is the third leading cause of cancer mortality in the United States, following lung and colon cancer respectively [1]. The etiology of pancreatic adenocarcinoma is predominantly focused on genetic inheritance and mutations.…”

Section: Introductionmentioning

confidence: 99%

“…Environmental factors in disease pathogenesis are well documented and include obesity, tobacco, alcohol, chronic pancreatitis, and diabetes mellitus. Some of the non-modifiable risk factors include metabolic syndrome, diabetes mellitus and hereditary forms of chronic pancreatitis [1]. Current diagnostic and screening protocols remain poor and, ultimately, these cancers are found late with poor prognosis.…”

Section: Introductionmentioning

confidence: 99%

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Locally Invasive Pancreatic Adenocarcinoma Presenting in the Splenic Flexure: A Rare Case Report

Ekanayake

Jenkins

Swade

et al. 2020

Cureus

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Pancreatic adenocarcinoma is a malignant cancer seen predominantly in males presenting with high-risk factors including chronic pancreatitis, familial history of cancer, and tobacco and alcohol abuse. The etiology of pancreatic adenocarcinoma is deceptive, and research continues to investigate its molecular patterns. Herein, we present a case of a 74-year-old Caucasian male who presented to the emergency department (ED) with tarry stools and hematochezia in the rectum for two weeks. Colonoscopy was terminated prematurely due to a mass at 70 cm within the splenic flexure of the colon. Exploratory laparotomy revealed a palpable mass at the splenic flexure invading the spleen. Splenectomy, distal pancreatoduodenectomy, and left hemicolectomy were performed. Pathological imaging revealed locally invasive pancreatic adenocarcinoma presenting in the splenic flexure, pancreatic parenchyma, peripancreatic soft tissue, and colonic wall. The patient is currently undergoing chemotherapy and radiation treatment. Below, we discuss risk factors, pathology, screening methods, and current treatment guidelines regarding pancreatic cancer. When pancreatic adenocarcinoma becomes metastatic, it most commonly involves the liver and lungs, but the review of current literature shows that limited cases of local invasion to the splenic flexure have been reported.

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Metastatic pancreatic cancer with multiple metastases confined to the large intestine: a case report and literature review

Omatsu,

Nakano,

Esaka

et al. 2023

Clin J Gastroenterol

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Pancreatic Adenocarcinoma With Rare Sigmoid Colon Metastasis

Cited by 11 publications

References 13 publications

A Rare Case of Pancreatic Adenocarcinoma With Incidental Synchronous Hepatic and Sigmoid Colonic Metastasis: A Case Report and Literature Review

A Rare Case of Pancreatic Adenocarcinoma With Incidental Synchronous Hepatic and Sigmoid Colonic Metastasis: A Case Report and Literature Review

Locally Invasive Pancreatic Adenocarcinoma Presenting in the Splenic Flexure: A Rare Case Report

Metastatic pancreatic cancer with multiple metastases confined to the large intestine: a case report and literature review

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