Pancreatic and renal function in streptozotocin-induced type 2 diabetic rats administered combined inositol hexakisphosphate and inositol supplement

Foster, Shadae R.; Dilworth, Lowell; Omoruyi, Felix O.; Thompson, Rory; Alexander-Lindo, Ruby

doi:10.1016/j.biopha.2017.09.126

Cited by 9 publications

(7 citation statements)

References 39 publications

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“…These results are not in agreement with liver morphology, absolute liver weight, and serum markers of liver damage [17]. Serum markers of kidney damage, creatinine, uric acid, and urea nitrogen concentrations indicated that treatment of diabetic rats with combined IP6 and inositol supplement caused no adverse effect on kidney integrity [17]. The serum biochemical markers did not agree with absolute and relative kidney weight which could suggest that relative and absolute kidney weight results are either misleading or significant changes in kidney weight occurred before serum biochemical changes.…”

Section: Discussionmentioning

confidence: 93%

“…However, there was a significant increase in relative weights of the liver or kidney in the treated and untreated diabetic groups compared to the normal control group, which may be indicative of liver or kidney hypertrophy. These results are not in agreement with liver morphology, absolute liver weight, and serum markers of liver damage [17]. Serum markers of kidney damage, creatinine, uric acid, and urea nitrogen concentrations indicated that treatment of diabetic rats with combined IP6 and inositol supplement caused no adverse effect on kidney integrity [17].…”

Section: Discussionmentioning

confidence: 99%

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Combined Inositol Hexakisphosphate and Inositol Supplement Consumption Improves Serum Alpha-Amylase Activity and Hematological Parameters in Streptozotocin-Induced Type 2 Diabetic Rats

Foster¹,

Dilworth²,

Sparks

et al. 2019

Advances in Pharmacological Sciences

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This study evaluated the effect of combined inositol hexakisphosphate (IP6) and inositol supplement on organ weight, intestinal ATPase activities, complete blood count, and serum analytes in streptozotocin (STZ)-induced type 2 diabetic rats. High-fat diet and a single intraperitoneal injection of streptozotocin (35 mg/kg body weight) were used to induce type 2 diabetes mellitus in Sprague–Dawley rats. The diabetic groups were then treated with either combined IP6 and inositol supplement or glibenclamide for four weeks. Organ weights, intestinal ATPase activities, complete blood count, serum α-amylase, total protein, albumin, and globulin content were determined. Pancreatic weight was significantly reduced while relative kidney and liver weights were elevated in the group treated with combined IP6 and inositol supplement compared to the nondiabetic control. Serum α-amylase activity for the glibenclamide and combination treated groups was significantly improved compared to that of the untreated diabetic group. Red cell distribution width percentage was significantly lower in the combination treated group compared to that in the untreated diabetic group, while intestinal ATPase activities were unaffected by the treatment regime. Combined IP6 and inositol supplement consumption may protect people with diabetes from increased risk of cardiovascular diseases due to the supplement's ability to maintain red cell distribution width percentage towards the normal control group.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Combined Inositol Hexakisphosphate and Inositol Supplement Consumption Improves Serum Alpha-Amylase Activity and Hematological Parameters in Streptozotocin-Induced Type 2 Diabetic Rats

Foster¹,

Dilworth²,

Sparks

et al. 2019

Advances in Pharmacological Sciences

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“…Long-term hyperglycemia can induce secondary complications such as renal damage (3). Diabetic nephropathy (DN), a major cause of end-stage renal disease and cardiovascular disease (4), is characterized by an elevated lipid profile and increased oxidative stress (5).…”

Section: Introductionmentioning

confidence: 99%

The Antidiabetic and Antinephritic Activities of Auricularia cornea (An Albino Mutant Strain) via Modulation of Oxidative Stress in the db/db Mice

et al. 2019

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This study first systematically analyzed the constituents of an albino mutant strain of Auricularia cornea (AU). After 8 weeks of continuous treatment with metformin (Met) (0.1 g/kg) and AU (0.1 and 0.4 g/kg), db/db mice showed hypoglycemic functioning, indicated by reduced bodyweight, food intake, plasma glucose, serum levels of glycated hemoglobin A1c and glucagon, hepatic levels of phosphoenolpyruvate carboxykinase and lucose-6-phosphatasem, and increased serum levels of insulin. The effect of hypolipidemic functions were indicated by suppressed levels of total cholesterol and triglyceride, and enhanced levels of hepatic glycogen and high-density lipoprotein cholesterol. The renal protective effect of AU was confirmed by the protection in renal structures and the regulation of potential indicators of nephropathy. The anti-oxidative and anti-inflammatory effects of AU were verified by a cytokine array combined with an enzyme-linked immunosorbent assay. AU decreased the expression of protein kinase C α and β2 and phosphor-nuclear factor-κB, and enhanced the expression of catalase, nuclear respiratory factor 2 (Nrf2), manganese superoxide dismutase 2, heme oxygenase-1 and−2, heat shock protein 27 (HSP27), HSP60, and HSP70 in the kidneys of db/db mice. The results confirmed that AU's anti-diabetic and anti-nephritic effects are related to its modulation on oxidative stress.

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“…The role of apolipoprotein L1 (APOL1) is not yet clear but it has been associated with the lipid biology in the podocyte ( Fornoni et al, 2014 ). Copy number variants of the multiple inositol-polyphosphate phosphatase 1 ( MINPP1 ) gene have been associated with varying levels of inositol hexaphosphate (IP6) ( Waugh, 2016 ) and IP6 has been reported to suppress lipid peroxidation ( Foster et al, 2017 ). Apolipoprotein 3 (APOC3) is a key player in triglyceride-rich lipoprotein metabolism ( Ramms and Gordts, 2018 ) and regulated by the peroxisome proliferator-activated receptor-α ( Liu et al, 2015 ).…”

Section: Resultsmentioning

confidence: 99%

Multi-Omic Approach to Identify Phenotypic Modifiers Underlying Cerebral Demyelination in X-Linked Adrenoleukodystrophy

Richmond

Kloet

Vaz

et al. 2020

Front. Cell Dev. Biol.

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X-linked adrenoleukodystrophy (ALD) is a peroxisomal metabolic disorder with a highly complex clinical presentation. ALD is caused by mutations in the ABCD1 gene, and is characterized by the accumulation of very long-chain fatty acids in plasma and tissues. Disease-causing mutations are 'loss of function' mutations, with no prognostic value with respect to the clinical outcome of an individual. All male patients with ALD develop spinal cord disease and a peripheral neuropathy in adulthood, although age of onset is highly variable. However, the lifetime prevalence to develop progressive white matter lesions, termed cerebral ALD (CALD), is only about 60%. Early identification of transition to CALD is critical since it can be halted by allogeneic hematopoietic stem cell therapy only in an early stage. The primary goal of this study is to identify molecular markers which may be prognostic of cerebral demyelination from a simple blood sample, with the hope that blood-based assays can replace the current protocols for diagnosis. We collected six well-characterized brother pairs affected by ALD and discordant for the presence of CALD and performed multi-omic profiling of blood samples including genome, epigenome, transcriptome, metabolome/lipidome, and proteome profiling. In our analysis we identify discordant genomic alleles present across all families as well as differentially abundant molecular features across the omics technologies. The analysis was focused on univariate modeling to discriminate the two phenotypic groups, but was unable to identify statistically significant candidate molecular markers. Our study

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Pancreatic and renal function in streptozotocin-induced type 2 diabetic rats administered combined inositol hexakisphosphate and inositol supplement

Cited by 9 publications

References 39 publications

Combined Inositol Hexakisphosphate and Inositol Supplement Consumption Improves Serum Alpha-Amylase Activity and Hematological Parameters in Streptozotocin-Induced Type 2 Diabetic Rats

Combined Inositol Hexakisphosphate and Inositol Supplement Consumption Improves Serum Alpha-Amylase Activity and Hematological Parameters in Streptozotocin-Induced Type 2 Diabetic Rats

The Antidiabetic and Antinephritic Activities of Auricularia cornea (An Albino Mutant Strain) via Modulation of Oxidative Stress in the db/db Mice

Multi-Omic Approach to Identify Phenotypic Modifiers Underlying Cerebral Demyelination in X-Linked Adrenoleukodystrophy

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