Pancreatic cancer associated with obesity and diabetes: an alternative approach for its targeting

Pothuraju, Ramesh; Rachagani, Satyanarayana; Junker, Wade M.; Chaudhary, Sanjib; Saraswathi, Viswanathan; Kaur, Sukhwinder; Batra, Surinder K.

doi:10.1186/s13046-018-0963-4

Cited by 90 publications

(71 citation statements)

References 183 publications

(177 reference statements)

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“…Overweight, that frequently characterized type 2 diabetes, could play a crucial role in carcinogenesis [62,63]. Adipose tissue is a complex endocrine organ able to secrete a variety of bioactive molecules (cytokines, free fatty acids, TNFalfa, plasminogen activator inhibitor-1 (PAI-1) and adiponectin) which may lead malignant transformation and progression [64]. Further, adipose tissue microenvironment promotes concomitant systemic endocrine alterations (obesity-related insulin resistance, hyperinsulinemia, sustained hyperglycemia) which, in turn, are involved in cancer development [65].…”

Section: Long-standing Diabetes Several Mechanisms Have Been Suggestementioning

confidence: 99%

Exploring the link between diabetes and pancreatic cancer

Pizzato

Turati

Rosato

et al. 2019

Expert Review of Anticancer Therapy

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Introduction: Epidemiological studies indicate an association between type 2 diabetes and pancreatic cancer but the complex and multidirectional relationship between them remains unclear. Areas covered: We summarized epidemiological evidence on diabetes and pancreatic cancer exploring the time-risk relationship. We described mechanisms linking long-standing diabetes to pancreatic cancer. We discussed pancreatic cancer-associated diabetes and its implication in the early detection of pancreatic cancer. Expert opinion: The markedly increased risk of pancreatic cancer in patients with new-onset diabetes compared with long-standing diabetes indicates a complex and bidirectional connection, with long-standing diabetes being a predisposing factor for pancreatic cancer (increasing the risk of the malignancy 1.5-to 2fold) and new-onset diabetes an early manifestation of the tumour. Identifying clinical features and biomarkers to distinguish pancreatic cancer-associated diabetes from type 2 diabetes is an important goal to improve management and survival of this cancer. Imaging (MRI) for middle age patients with new-onset diabetes may be considered.

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Section: Long-standing Diabetes Several Mechanisms Have Been Suggestementioning

confidence: 99%

Exploring the link between diabetes and pancreatic cancer

Pizzato

Turati

Rosato

et al. 2019

Expert Review of Anticancer Therapy

View full text Add to dashboard Cite

show abstract

“… 1 , 2 Some studies have shown that smoking, obesity, diabetes and pancreatitis are risk factors for PC, and approximately 10% of PC patients have a family background. 3 - 6 The prevalence of obesity is high in Chinese population. 7 - 9 Delineating obesity could be a beneficial strategy to combat PC.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Knockdown EIF3C Suppresses Cell Proliferation and Increases Apoptosis in Pancreatic Cancer Cell

et al. 2020

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Increasing evidence shows that eukaryotic initiation factor subunit (EIF3C) plays a crucial role in development of tumors. However, the underlying roles of EIF3Cin the development of pancreatic cancer (PC) remain unknown. In this study, we examined the expression of EIF3C in PC tissues, their adjacent normal tissues and 3 cell lines (SW1990, PANC-1 and AsPC-1). Moreover, the EIF3C-shRNA lentivirus was constructed to suppress EIF3C expression. Following this, the cell colony formation assay was employed to evaluate proliferation ability of PC cells. Meanwhile, the cell cycle and apoptotic assays were also performed by flow cytometry. We found that level of EIF3C in PC tissues was significantly increased compared with that in adjacent normal tissues. Furthermore, the knockdown of EIF3C can significantly reduce cell proliferation, block cell cycle in G2/M and induce apoptosis in both SW1990 and PANC-1 cells. Our findings suggest that EIF3C plays a crucial role in the progression of PC and may be a potential target in the treatment of PC.

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“…The prevalence of childhood obesity remains increasing in recent decades, which is alarming because it is also associated with health consequences such as metabolic syndrome, diabetes, cardiovascular diseases and even many types of cancers in adulthood 1 2. Once a child is obese that is more likely to remain during adulthood 3–5.…”

Section: Introductionmentioning

confidence: 99%

Maternal postload 1-hour glucose level during pregnancy and offspring’s overweight/obesity status in preschool age

Shi¹,

Huang

Wang

et al. 2020

BMJ Open Diab Res Care

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BackgroundChildhood obesity is associated with adverse outcomes such as metabolic syndrome, diabetes, and cardiovascular diseases in adulthood. Identifying risk factors related to excessive adiposity in early childhood is of great importance for obesity intervention. The results of studies for associations between maternal with gestational diabetes and offspring obesity are conflicting. Nonetheless, the association of maternal glucose across a spectrum of glucose values with childhood adiposity outcomes is less clear.AimTo assess the association of maternal glucose across a spectrum of glucose values with childhood adiposity at age 5 years.MethodsA population-based cohort study was conducted between 2011 and 2018. Using the healthcare records data were from the Medical Birth Registry in Xiamen, China. The primary outcome was offspring obese/obesity. Primary predictors were maternal oral glucose tolerance test values during pregnancy.Results6090 mother–child pairs were analyzed. The mean age of the children at follow-up was 5.2 years. At multiple logistic regression, after adjustment for variables, including maternal pre-pregnancy body mass index (BMI), birth weight of offspring, and insulin therapy, ORs for offspring overweight/obesity were 1.13 (95% CI 0.90 to 1.42) for maternal fasting glucose levels, 1.12 (95% CI 1.04 to 1.22) for 1-hour glucose, and 1.04 (95% CI 0.95 to 1.14) for 2-hour glucose. The adjusted association of offspring BMI Z-score with maternal 1-hour glucose level remained significant. There were no significant associations between BMI Z-score and maternal fasting glucose and 2-hour glucose level. Exploratory sex-specific analyses indicated generally consistent associations for boys and girls.ConclusionMaternal postload 1-hour glucose across a spectrum of glucose values during pregnancy was an independent risk for offspring weight gain at age 5 years, indicating the importance of screen and management of maternal 1-hour glucose level, except for fasting glucose and 2-hour glucose level during pregnancy in order to prevent offspring weight gain in early childhood.

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Pancreatic cancer associated with obesity and diabetes: an alternative approach for its targeting

Cited by 90 publications

References 183 publications

Exploring the link between diabetes and pancreatic cancer

Exploring the link between diabetes and pancreatic cancer

RETRACTED: Knockdown EIF3C Suppresses Cell Proliferation and Increases Apoptosis in Pancreatic Cancer Cell

Maternal postload 1-hour glucose level during pregnancy and offspring’s overweight/obesity status in preschool age

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