Pancreatic cancer in patients with chronic calcifying pancreatitis: Computed tomography findings – a retrospective analysis of 48 patients

Mohamed, Amir; Ayav, Ahmet; Belle, Arthur; Orry, Xavier; Chevaux, Jean–Baptiste; Laurent, V.

doi:10.1016/j.ejrad.2016.11.018

Cited by 11 publications

(10 citation statements)

References 27 publications

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“…“Cyst wall” indicates calcification that was found beside the cyst, and “septum” indicates calcification that was present in the cyst bulkhead. A central calcified scar consisted of calcified septations radiating outwards with a sunburst or stellate appearance called as stellate central calcifications [ 6 , 8 , 12 ].…”

Section: Methodsmentioning

confidence: 99%

“…The discrepancies between the three readers’ interpretations were submitted to an imaging seminar, which was led by a senior radiologist (Weimin Chai) with more than 25 years of experience in this field, to resolve the discrepancies by consensus. The radiologists were both blinded to the pathology results and the clinical outcomes [ 8 ]. All discussion and results were recorded by the junior radiologist and approved by the team members.…”

Section: Methodsmentioning

confidence: 99%

“…However, pancreatic calcifications (PC) have also been noted in patients with many other pancreatic diseases [ 6 ]. The pattern of calcifications in different diseases is not clear in China, and whether PC were associated with malignancy of pancreatic diseases is not determined because there are very few articles focusing on these issues and most of them have small sample sizes [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Clinical significance of pancreatic calcifications: a 15-year single-center observational study

et al. 2022

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Objectives Pancreatic calcifications (PC) are considered specific for chronic pancreatitis (CP), but PC may also be present in non-CP diseases. The aims are to understand the pattern of calcifications in different diseases and to determine they were related to malignant diseases. Methods A retrospective study was performed including patients with PC or CP undergoing surgery in the Department of General Surgery of Ruijin Hospital from January 2003 to June 2018. Results PC were observed in 168 (4.5%) of the 3755 patients with pancreatic lesions treated during the study period. The majority of patients with PC had three kinds of CP (73.2%) while 26.8% had other five kinds of non-CP diseases. In patients with non-CP diseases, the incidence of PC in malignant intraductal papillary mucinous neoplasm (IPMN) was significantly higher than benign IPMN (8.3% vs. 0.7%, p = 0.004). In patients of CP with pancreatic mass (n = 81), PC (Odds ratio = 28.6, p = 0.000), advanced age (> 55 years) and parenchymal atrophy were independent predictors for malignancy. In patients of CP without pancreatic mass (n = 110), there were 82 cases (74.5%) with PC and 5 cases (4.5%) with pancreatic ductal adenocarcinoma. The regression model of risk factors was not successful. Conclusions The disease spectrum with PC was very diverse. PC may be related to malignant IPMN in non-CP diseases and is related to malignancy in the patients of CP with pancreatic mass and indications for resection.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical significance of pancreatic calcifications: a 15-year single-center observational study

et al. 2022

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“…A retrospective study analyzed discriminatory signs on CT for patients with chronic calcifying pancreatitis and eventually developed PC. It was concluded that a hypodense mass at diagnosis is a predictive factor ( 39 ). As mentioned above, combinations of CT modalities have improved its efficacy to a large extent.…”

Section: Detection Methodsmentioning

confidence: 99%

Metastatic pancreatic cancer: Mechanisms and detection (Review)

et al. 2021

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Pancreatic cancer (PC) is a lethal malignancy. Its prevalence rate remains low but continues to grow each year. Among all stages of PC, metastatic PC is defined as late-stage (stage IV) PC and has an even higher fatality rate. Patients with PC do not have any specific clinical manifestations. Most cases are inoperable at the time-point of diagnosis. Prognosis is also poor even with curative-intent surgery. Complications during surgery, postoperative pancreatic fistula and recurrence with metastatic foci make the management of metastatic PC difficult. While extensive efforts were made to improve survival outcomes, further elucidation of the molecular mechanisms of metastasis poses a formidable challenge. The present review provided an overview of the mechanisms of metastatic PC, summarizing currently known signaling pathways (e.g. epithelial-mesenchymal transition, NF-κB and KRAS), imaging that may be utilized for early detection and biomarkers (e.g. carbohydrate antigen 19-9, prostate cancer-associated transcript-1, F-box/LRR-repeat protein 7 and tumor stroma), giving insight into promising therapeutic targets.

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“…Calcification of pancreatic adenocarcinoma is reported when it occurs in the background of chronic calcific pancreatitis (CCP). [1] In the absence of CCP, calcification in pancreatic adenocarcinoma is very uncommon. Calcification is more commonly seen in benign pancreatic masses such as solid pseudopapillary epithelial neoplasm, serous cystadenoma, and mucinous cystic neoplasm.…”

Section: Review Of Literaturementioning

confidence: 99%

Pancreatic Adenocarcinoma with Primary Tumor Calcification and Calcified Liver Metastasis: Report of a Rare Case and Review of Literature

Ghosh

Ganguly

Dabkara

et al. 2020

Indian Journal of Medical and Paediatric Oncology

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Calcification is a feature of benign pancreatic diseases such as chronic calcific pancreatitis (CCP) or benign pancreatic tumors such as solid and papillary epithelial neoplasm of the pancreas and serous cystadenoma. The presence of calcification in a primary malignant pancreatic tumor is uncommon except for neuroendocrine tumors of the pancreas. Calcification in adenocarcinoma of the pancreas involving the primary tumor as well as the metastasis resulting thereof is extremely rare in the absence of CCP. To our knowledge, this is the first report of a case of primary adenocarcinoma of the pancreas that presented with calcification of the primary tumor as well as the metastatic liver nodules, accompanied by hypercalcemia.

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Pancreatic cancer in patients with chronic calcifying pancreatitis: Computed tomography findings – a retrospective analysis of 48 patients

Abstract: The presence of a pancreatic mass in a patient with CCP is suggestive of malignancy, especially when few pancreatic calcifications are observed (that are pushed aside by the tumor) and when the tumor causes dilation of the common bile duct and main pancreatic duct.

Cited by 11 publications

References 27 publications

Clinical significance of pancreatic calcifications: a 15-year single-center observational study

Clinical significance of pancreatic calcifications: a 15-year single-center observational study

Metastatic pancreatic cancer: Mechanisms and detection (Review)

Pancreatic Adenocarcinoma with Primary Tumor Calcification and Calcified Liver Metastasis: Report of a Rare Case and Review of Literature

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