Pancreatic cancer therapy using an injectable nanobiohybrid hydrogel

Phan, Vu To-Anh; Lee, Eun‐Hye; Maeng, Jin Hee; Thambi, Thavasyappan; Kim, Bong Sup; Donheang, Lee; Lee, Sang Soo

doi:10.1039/c6ra07934b

Cited by 50 publications

(26 citation statements)

References 56 publications

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“…41 The peak around 3365 cm À1 is caused by the amine group (-NH) in the urea linkage. 42 For the PUFs, an -NCO peak was not observed around 2265 cm À1 . The disappearance of the -NCO peak aer reaction with the -OH group in glycerin and water indicates that the urethane and urea linkage was well-formed without an unreacted -NCO group.…”

Section: Physicochemical Characterization Of Pufsmentioning

confidence: 90%

AgNP and rhEGF-incorporating synergistic polyurethane foam as a dressing material for scar-free healing of diabetic wounds

et al. 2017

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Section: Physicochemical Characterization Of Pufsmentioning

confidence: 90%

AgNP and rhEGF-incorporating synergistic polyurethane foam as a dressing material for scar-free healing of diabetic wounds

et al. 2017

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“…PCLA‐PEG‐PCLA (triBLOCK) copolymer was synthesized using a ring‐opening copolymerization reaction of ε‐caprolactone (CL) and d , l ‐Lactide, in the presence of PEG and Sn(Oct) 2 , based on a method described previously . The synthetic procedure is outlined in Scheme 2 a and comprises the following steps: adding 12 g (1.2 mmol) PEG and 0.15 g (0.37 mmol) of Sn(Oct) 2 to a three‐neck round‐bottom flask and vacuum‐drying at 110 °C for 1.5 h to remove trace amounts of water, cooling to 60 °C and adding 5.14 g (45 mmol) CL and 2.16 g (15 mmol) LA, vacuum‐drying the reaction mixture again for 1 h at 60 °C, performing the reaction at 130 °C for 24 h under dry nitrogen, allowing the flask to cool to room temperature and dissolving the crude product in chloroform, precipitating the product in a 50/50 v/v mixture of diethyl ether and n‐hexane, and vacuum‐drying the final product at room temperature for 48 h.…”

Section: Methodsmentioning

confidence: 99%

“…Sol–gel phase transitions of the triBLOCK and triBLOCK mixed heparin‐loaded triBLOCK (Nac‐hep‐triBLOCK:triBLOCK (1:3)) were determined using the tube‐inversion method, in which the sample vials were inverted and the flow of the different states was then observed for 1 min . Briefly, the optimum tuned ratios were selected using a viscosity test.…”

Section: Methodsmentioning

confidence: 99%

“…Stimuli‐responsive hydrogels comprising hydrophilic polyethylene glycol (PEG) and hydrophobic biodegradable polyesters have been studied for use in various biomedical applications . Poly(ε‐caprolactone‐ co ‐lactide)‐b‐poly(ethylene glycol)‐b‐poly(ε‐caprolactone‐ co ‐lactide) (PCLA‐PEG‐PCLA) hydrogels exhibit thermo‐reversible sol‐to‐gel transition in aqueous solutions and represent a promising candidate for injectable sustained release and local drug delivery . The PCLA‐PEG‐PCLA hydrogel is characterized by its capacity to undergo reversible volume‐phase transitions in response to subtle changes in the surrounding temperature.…”

Section: Introductionmentioning

confidence: 99%

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Non‐Anticoagulant Heparin Prodrug Loaded Biodegradable and Injectable Thermoresponsive Hydrogels for Enhanced Anti‐Metastasis Therapy

Andrgie

Mekuria

Addisu

et al. 2019

Macromolecular Bioscience

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required for successful cancer metastasis are: detachment of cancer cells from the primary mass, invasion of the local host tissue stroma, penetration of local lymphatic and blood vessels, survival during circulation, arrest in the capillaries of other organs, formation of microemboli, extravasation, and proliferation within the organ parenchyma. [8][9][10][11] The main challenges for metastasis treatment are systemic complexity, therapeutic resistance, and difficulty in early diagnosis. [10] Currently, there are no medicines available to specifically prevent cancer cell metastasis, but the development of inhibitory agents that selectively suppress or block metastasis-associated mechanisms provide an alternative for metastatic treatments. [12,13] Anti-metastasis therapy mainly focuses on interrupting the metastatic cascade of tumor cells. Even if the types of therapy depend on the timing of diagnosis, the typical anti-metastasis strategies are designed to block the initiation of metastasis, intercept and eradicate circulating tumor cells, and limit the formation of tumor cell colonies at distant organs. [14] For instance, MMP inhibitors, the Axl kinase inhibitor R428, miR-10b antagonists, and the fascin inhibitor Migrastatin are used as anti-metastatic agents for impairing the initial dissemination events. However effective anti-metastatic therapeutic agents must be capable of destroying the proliferation and survival of already disseminated tumor cells, rather than only seeking to block the exit of these cells from the primary tumor. [8] Treatments that involve a targeted sustained release of chemotherapeutic agents are the most prevalent approach to cancer treatment and inhibition of tumor metastasis. [15] Studies on cancer research have investigated hydrogels, nanoparticles, micelles, and liposomes for enhancing the efficacy of tumor treatment. Current studies on polymer-based tumor therapeutic systems focus on achieving the following goals: 1) providing anti-metastatic effects, 2) specific drug release in the tumor tissue, 3) enhanced antitumor efficacy, and 4) good biocompatibility and biodegradable properties of the nanoparticles. [16] Nevertheless, intravenous administration of therapeutic agents often leads to adverse systemic effects and rapid clearance from the circulating blood. Furthermore, frequent administration of anti-metastatic agents Injectable HydrogelsMetastasis is a pathogenic spread of cancer cells from the primary site to surrounding tissues and distant organs, making it one of the primary challenges for effective cancer treatment and the major cause of cancer mortality. Heparin-based biomaterials exhibit significant inhibition of cancer cell metastasis. In this study, a non-anticoagulate heparin prodrug is developed for metastasis treatment with a localized treatment system using temperature sensitive, injectable, and biodegradable (poly-(ε-caprolactone-co-lactide)-bpoly(ethylene glycol)-b-poly(ε-caprolactone-co-lactide) polymeric hydrogel. The drug molecule (heparin) is conjugated with th...

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“…Hydrogels can be divided into chemical and physical gels depending on the nature of crosslinking [ 30 ]. These systems possess unique properties to improve the efficacy of the therapeutic agents and minimize undesirable side effects [ 31 ]. For an effective therapy, topical and transdermal application of antineoplastic agents from a drug delivery system can mitigate the side effects while improving the drug's efficacy [ 32 ].…”

Section: Drug Delivery Systems Based On Hydrogelsmentioning

confidence: 99%

Recent Advances in Hydrogel-Based Drug Delivery for Melanoma Cancer Therapy: A Mini Review

Vishnubhakthula

Elupula

Durán-Lara

2017

Journal of Drug Delivery

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The purpose of this study is to describe some of the latest advances in using hydrogels for cancer melanoma therapy. Hydrogel formulations of polymeric material from natural or synthetic sources combined with therapeutic agents have gained great attention in the recent years for treating various maladies. These formulations can be categorized according to the strategies that induce cancer cell death in melanoma. First of all, we should note that these formulations can only play a supporting role that releases bioactive agents against cancer cells rather than the main role. This strategy involves delivering the drug via transdermal pathways, resulting in the death of cancerous cells. Another strategy utilizes magnetic gel composites to combat melanoma via hyperthermia therapy. This review discusses both transdermal and hyperthermia therapies and the recent advances that have occurred in the field.

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Pancreatic cancer therapy using an injectable nanobiohybrid hydrogel

Abstract: Nanobiohybrid hydrogels, composed of biocompatible inorganic nanoparticles and biodegradable polymeric hydrogels, have been developed as the sustained delivery carrier of gemcitabine for the treatment of pancreatic cancer.

Cited by 50 publications

References 56 publications

AgNP and rhEGF-incorporating synergistic polyurethane foam as a dressing material for scar-free healing of diabetic wounds

AgNP and rhEGF-incorporating synergistic polyurethane foam as a dressing material for scar-free healing of diabetic wounds

Non‐Anticoagulant Heparin Prodrug Loaded Biodegradable and Injectable Thermoresponsive Hydrogels for Enhanced Anti‐Metastasis Therapy

Recent Advances in Hydrogel-Based Drug Delivery for Melanoma Cancer Therapy: A Mini Review

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