Pancreatic cystic neoplasms: Review of current knowledge, diagnostic challenges, and management options

Jana, Tanima; Shroff, Jennifer; Bhutani, Manoop S.

doi:10.4103/1477-3163.153285

Cited by 23 publications

(12 citation statements)

References 122 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Solid pseudopapillary tumors,[ 39 40 ] cystic neuroendocrine neoplasms of the pancreas,[ 41 42 43 44 ] acinar cell neoplasms,[ 45 ] and pancreatic adenocarcinomas (adenosquamous and/or anaplastic carcinoma)[ 46 ] can occasionally appear as cystic masses.…”

Section: True Cysts — Nonneoplasmsmentioning

confidence: 99%

Morphological differentiation and follow-up of pancreatic cystic neoplasms using endoscopic ultrasound

et al. 2015

View full text Add to dashboard Cite

Endoscopic ultrasound (EUS) is a key modality for the evaluation of suspected pancreatic cystic neoplasms (PCNs), as the entire pancreatic gland can be demonstrated with high spatial resolution from the stomach and duodenum. Detailed information can be acquired about the internal contents of the cyst(s) [septum, capsule, mural nodules (MNs)], its relation with the main pancreatic duct (MPD), and any parenchymal changes in the underlying gland. PCNs comprise true cysts and pseudocysts. True cysts can be neoplastic or nonneoplastic. Here, we describe serous cystic neoplasm (SCN), mucinous cystic neoplasm (MCN), and intraductal papillary mucinous neoplasm (IPMN) as prototype neoplastic cysts, along with nonneoplastic lymphoepithelial cysts (LECs).

show abstract

Section: True Cysts — Nonneoplasmsmentioning

confidence: 99%

Morphological differentiation and follow-up of pancreatic cystic neoplasms using endoscopic ultrasound

et al. 2015

View full text Add to dashboard Cite

show abstract

“…The differential diagnoses of pancreatic cystic tumors might include pancreatic schwannoma, SCN, mucinous cystic neoplasm, pancreatic neuroendocrine tumor (P-NET), solid pseudopapillary neoplasm (SPN), and intraductal papillary mucinous neoplasm (IPMN) [ 8 , 9 , 10 ]. These tumors share imaging features using various modalities, and preoperative differential diagnosis of pancreatic schwannoma from the others is difficult.…”

Section: Discussionmentioning

confidence: 99%

A Surgically Resected Pancreatic Schwannoma with Obstructive Jaundice with Special Reference to Differential Diagnosis from Other Cystic Lesions in the Pancreas

Watanabe

Araki

Ishii

et al. 2018

Case Rep Gastroenterol

View full text Add to dashboard Cite

Pancreatic schwannomas are uncommon. About 60% of pancreatic schwannomas develop cystic lesions, and the differential diagnosis from other cystic pancreatic tumors is difficult. A 43-year-old man presented for evaluation of liver dysfunction detected during a medical checkup. Blood testing detected obstructive jaundice. A computed tomography scan revealed a well-defined polycystic tumor of about 5 cm at the pancreatic head. We performed surgical resection to treat the patient’s symptoms and facilitate long-term management. Histopathological examination revealed spindle-shaped cells. Immunohistochemical studies showed S100 protein expression and the absence of CD34 and c-kit protein expression. Finally, we diagnosed a schwannoma. Pancreatic schwannoma is usually asymptomatic. The present case presented with obstructive jaundice, which is reportedly a rare symptom. Pancreatic schwannomas should be considered as a differential diagnosis of pancreatic cystic tumors. Dilatation of the pancreatic duct and the 18-fluorodeoxyglucose positron emission tomography findings are important for the differential diagnosis.

show abstract

“…[14, 38] In the absence of invasive disease, and in the absence of a site of predominant disease, total pancreatectomy should be considered. This operation should be reserved for selected patients with obvious diffuse disease or to those in whom the intraoperative finding of high grade dysplasia on frozen section dictates completion pancreatectomy.…”

Section: Outcome and Long-term Recommendationsmentioning

confidence: 99%

Therapeutic Approach to Cystic Neoplasms of the Pancreas

Efishat

Allen

2016

Surgical Oncology Clinics of North America

View full text Add to dashboard Cite

Given the widespread use of high quality cross-sectional imaging, cystic lesions of the pancreas are being diagnosed more frequently. Management of these lesions is challenging as it largely depends on radiologic and cyst fluid markers to discriminate between benign and pre-cancerous lesions, however the accuracy of these tests is limited, and unable to predict malignancy with certainty. While asymptomatic serous cystadenomas (SCA) can be managed conservatively, mucinous cystic neoplasms (MCN) and intraductal papillary mucinous neoplasms (IPMN) are more difficult to manage given their variable potential for malignancy. A selective approach, based on the preoperative likelihood of high-grade dysplasia or invasive disease, is now the standard of care. Current research is focusing on the development of pre-operative markers for discriminating between histopathologic sub-types, and for identifying the degree of dysplasia in patients with precancerous mucinous lesions. Improvements in these diagnostic tools will hopefully limit resection to patients with high-risk lesions, and spare patients with low-risk or benign lesions the risks of pancreatectomy.

show abstract

Pancreatic cystic neoplasms: Review of current knowledge, diagnostic challenges, and management options

Cited by 23 publications

References 122 publications

Morphological differentiation and follow-up of pancreatic cystic neoplasms using endoscopic ultrasound

Morphological differentiation and follow-up of pancreatic cystic neoplasms using endoscopic ultrasound

A Surgically Resected Pancreatic Schwannoma with Obstructive Jaundice with Special Reference to Differential Diagnosis from Other Cystic Lesions in the Pancreas

Therapeutic Approach to Cystic Neoplasms of the Pancreas

Contact Info

Product

Resources

About