Pancreatic Disease

Agonist activation of arachidonate‐regulated Ca2+‐selective (ARC) channels in murine parotid and pancreatic acinar cells

“…Nevertheless, to explore this idea further, we attempted to assess the relative contribution of the ARC channels to the overall [Ca 2+ ] i signals generated by agonists acting at muscarinic and CCK receptors using isotetrandrine. Both CCK receptors and muscarinic receptors are known to couple to the activation of cPLA 2 resulting in the generation of arachidonic acid (Tsunoda & Owyang, 1995;González et al 1999;Lankisch et al 1999;Mizuno et al 2000;Siegel et al 2001) and, as noted above, isotetrandrine acts to uncouple this receptor activation of cPLA 2 (Hashizume et al 1991;Akiba et al 1992). This inhibition, in turn, would be expected to inhibit the agonist-induced activation of the ARC channels, at least to the extent that they are dependent on arachidonic acid generated via the receptor activation of cPLA 2 .…”