Pancreatic Diseases and Diabetes

Unnikrishnan, Ranjit; Mohan, Viswanathan

doi:10.1002/9781118924853.ch21

Cited by 5 publications

(5 citation statements)

References 64 publications

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“…Another, increasingly frequent, form of pancreatic diabetes occurs in children with cystic fibrosis (CF) [39]. Pancreatic damage occurs due to ductal obstruction by abnormally viscid pancreatic secretions, leading to exocrine and ultimately endocrine pancreatic insufficiency.…”

Section: Introductionmentioning

confidence: 99%

Challenges in diagnosis and management of diabetes in the young

Unnikrishnan

Shah

Mohan

2016

Clin Diabetes Endocrinol

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The prevalence of diabetes in children and adolescents is increasing worldwide, with profound implications on the long-term health of individuals, societies, and nations. The diagnosis and management of diabetes in youth presents several unique challenges. Although type 1 diabetes is more common among children and adolescents, the incidence of type 2 diabetes in youth is also on the rise, particularly among certain ethnic groups. In addition, less common types of diabetes such as monogenic diabetes syndromes and diabetes secondary to pancreatopathy (in some parts of the world) need to be accurately identified to initiate the most appropriate treatment. A detailed patient history and physical examination usually provides clues to the diagnosis. However, specific laboratory and imaging tests are needed to confirm the diagnosis. The management of diabetes in children and adolescents is challenging in some cases due to age-specific issues and the more aggressive nature of the disease. Nonetheless, a patient-centered approach focusing on comprehensive risk factor reduction with the involvement of all concerned stakeholders (the patient, parents, peers and teachers) could help in ensuring the best possible level of diabetes control and prevention or delay of long-term complications.

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Section: Introductionmentioning

confidence: 99%

Challenges in diagnosis and management of diabetes in the young

Unnikrishnan

Shah

Mohan

2016

Clin Diabetes Endocrinol

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“…[24] Association of diabetes with pancreatic cancer is controversial with some studies, suggesting a two-fold increase in patients of diabetes of >5 years duration and others suggesting diabetes to be protective against pancreatic cancer. [25]…”

Section: Discussionmentioning

confidence: 99%

“…FCPD constitutes <1% of all cases of diabetes. [2] It has been suggested that the risk of developing pancreatic cancer is the highest in patients with FCPD as compared to all other forms of pancreatitis and is believed to be 100-fold greater than those without FCPD. [3] This case series intends to highlight the increased occurrence of pancreatic cancer in FCPD, an observation not previously reported from this part of India.…”

Section: Introductionmentioning

confidence: 99%

Pancreatic carcinoma in fibrocalcific pancreatic diabetes: An eastern India perspective

Chakraborty

Dutta

Biswas

et al. 2012

Indian J Endocr Metab

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“…The first report of pancreatic pathology leading to diabetes was published more than 200 years ago by Cawley [2], who described the presence of pancreatic calcification in a patient with diabetes. It is now well known that various forms of pancreatic pathology can result in diabetes, chief among them being chronic pancreatitis, cystic fibrosis, hemochromatosis and malignancy [3].…”

Section: Introductionmentioning

confidence: 99%

Fibrocalculous pancreatic diabetes (FCPD)

Unnikrishnan

Mohan

2014

Acta Diabetol

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Fibrocalculous pancreatic diabetes (FCPD) is an uncommon form of diabetes that occurs as a result of chronic calcific pancreatitis, in the absence of alcohol abuse. The disease is restricted to tropical regions of the world, and southern India has the highest known prevalence of FCPD. The typical patient with FCPD is a lean adolescent or young adult of either sex, presenting with history of recurrent bouts of abdominal pain and steatorrhea. Demonstration of large, discrete pancreatic calculi by plain radiographs or ultrasonography of the abdomen is diagnostic. While the exact etiology of FCPD is unknown, genetic, nutritional and inflammatory factors have been hypothesized to play a role. Diabetes in FCPD is often brittle and difficult to control; most patients require multiple doses of insulin for control of glycemia. However, in spite of high blood glucose levels, patients rarely develop ketosis. Malabsorption responds to pancreatic enzyme supplementation. Surgical removal of stones is indicated for symptomatic relief of intractable pain. While patients with FCPD develop microvascular complications as frequently as those with type 2 diabetes, macrovascular disease is uncommon. Development of pancreatic malignancy is the most dreaded complication and should be suspected in any patient who complains of weight loss, back pain or jaundice.

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Pancreatic Diseases and Diabetes

Cited by 5 publications

References 64 publications

Challenges in diagnosis and management of diabetes in the young

Challenges in diagnosis and management of diabetes in the young

Pancreatic carcinoma in fibrocalcific pancreatic diabetes: An eastern India perspective

Fibrocalculous pancreatic diabetes (FCPD)

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