Pancreatic endocrine tumor with neoplastic venous thrombus and bilobar liver metastasis. A case report

Barbier, Louise; Turrini, Olivıer; Sarran, Anthony; Delpero, Jean‐Robert

doi:10.1016/j.jviscsurg.2010.02.006

Cited by 10 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are only a few case reports analysing the relationship between DVT and liver metastasis. There is one case report of pancreatic endocrine tumour with neoplastic venous thrombus and bilobar liver metastasis (Barbier et al, 2010). The liver is the major organ that synthesizes procoagulants and anticoagulants.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic Carcinoma, Thrombosis and Mean Platelet Volume: Single Center Experience from the Southeast Region of Turkey

Afşar¹,

Günaldı²,

Kum³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: The aim of this study was to investigate the general characteristics of patients with deep vein thrombosis (DVT) and pancreatic cancer as well as evaluate the relationship between mean platelet volume (MPV), DVT and survival. Materials and Methods: Seventy-seven patients with pancreatic cancer, who were admitted to Cukurova University Medical Faculty, Department of Medical Oncology, were enrolled in the study Results: The mean age was 59±20. Forty-nine (63.6%) were men and 28 women (36.4%) . Sixty-eight (88.3%) patients had adenocarcinoma and 9 (11.7%) had a malignant epithelial tumor. Thirty-six (46.7%) had liver metastasis at diagnosis. Twenty-six (33.8%) patients were alive, 20 (26%) were dead and in 31 (40.2%) the status was unknown. Only 14 (18.1%) patients had DVT. In 42 (54.5%) patients MPV values were normal, in 28 (36.4%) patients they were above normal, and in 7 (9.1%) patients they were below normal. There was no statistically significant difference between gender, tumour localization, chemotherapy and survival rates (p:0.56, p:0.11, p:0.21). There was no significant difference between DVT, gender, localisation, histological subtype, the presence of metastasis, stage and if the patient had been treated with chemotherapy (p:0.5, p:0.6, p:0.2, p:0.32, p:0.1, p:0.84). There was also no significant difference between MPV and DVT (p:0.57) but there was a significant difference between liver metastasis and DVT (p:0.02). Age, stage, the presence of metastasis and DVT were prognostic in pancreatic cancer patients. Conclusions: Cases of pancreatic cancer with liver metastasis should be studied more carefully as thrombosis is more common in these patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Pancreatic Carcinoma, Thrombosis and Mean Platelet Volume: Single Center Experience from the Southeast Region of Turkey

Afşar¹,

Günaldı²,

Kum³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…1,2 Because of the paucity of data reported in the literature, the results of surgical resection of PNETs with MVI as well as the prognostic impact of venous invasion in these patients remain scarcely evaluated. 2,[9][10][11][12][13][14][15] This study aimed to evaluate the incidence, the impact on surgical outcomes and the survival of patients having PNETs with MVI resected at our centre.…”

Section: Introductionmentioning

confidence: 99%

Macrovascular venous invasion of pancreatic neuroendocrine tumours: impact on surgical outcomes and survival

Addeo

D’Alessandro

Avérous

et al. 2019

HPB

View full text Add to dashboard Cite

Background: This study evaluates the impact of macrovascular venous invasion (MVI) on surgical and survival outcomes of pancreatic neuroendocrine tumours (PNETs). Methods: We retrospectively reviewed data of 125 patients operated for PNETs. Operative, pathological,and survival outcomes were compared between PNETs with and without MVI.Results: Macrovascular venous invasion was detected in 25 of 125 PNETs (20%) presenting as tumour thrombi (n = 12) or venous wall invasion (n = 13). MVI was associated with larger tumours, a higher rate of lymph node involvement, less differentiated tumours, and a higher rate of perineural invasion. Resection of PNETS with MVI more often necessitated combined hepatic, venous and multivisceral resections, had a higher rate of intraoperative blood transfusion (p = 0.04) but similar morbidity (44% vs. 42%) and mortality (0 vs. 1%) as PNETs without MVI. PNETs with MVI had a lower median overall survival rate (60 vs. 149 months; p = 0.03). Multivariate analysis revealed that PNETs of the pancreatic head, synchronous liver metastases and higher tumour grade were prognostic factors for overall survival.Conclusions: MVI is found in more advanced PNETs. Resection of PNETs with MVI is characterized by increased transfusion rate and reduced overall survival.

show abstract

“…But splanchnic or PVT is exceedingly rare in solid metastatic tumors. [30][31][32] When we compare cholangiocarcinoma and metastatic liver tumor groups with HCC and cirrhosis with PVT groups, we detect interesting findings. Despite the significantly higher levels of the procoagulants (platelets, fibrinogen, CFs V, VII, VIII, IX, and XI) in cholangiocarcinoma and metastatic liver tumor groups, we cannot detect any PVT in these 2 groups.…”

Section: Discussionmentioning

confidence: 99%

Hemostatic Abnormalities in Cirrhosis and Tumor-Related Portal Vein Thrombosis

Alkım

Ayaz

Şaşmaz³

et al. 2011

Clin Appl Thromb Hemost

View full text Add to dashboard Cite

In order to investigate the relationship between hemostatic abnormalities and portal vein thrombosis (PVT) in hepatocellular carcinoma (HCC), platelets, prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time, fibrinogen, d-dimer, fibrinogen degradation products (FDPs), protein C, protein S, antithrombin, plasminogen, antiplasmin, coagulation factors (CFs) V, VII, VIII, IX, XI, and XIII, von Willebrand factor (vWF), prothrombin fragment 1 + 2 (PF 1 + 2), tissue-type plasminogen activator (tPA), and plasminogen activator inhibitor 1 (PAI-1) were studied in patients with HCC, cholangiocarcinoma, and metastatic liver tumors and in cirrhosis patients with or without PVT. Platelet, antithrombin, protein C, plasminogen, and CFs V, VII, IX, XI, and XIII levels of HCC group were found lower and PT, aPTT, thrombin time, vWF, FDPs, PF 1 + 2, tPA, and PAI-1 levels were higher than the control group. Our findings suggested that the abnormalities of coagulation and fibrinolysis systems have some role in provoking thrombosis of portal veins in HCC, in addition to the invasion of portal veins by hepatoma cells.

show abstract

Pancreatic endocrine tumor with neoplastic venous thrombus and bilobar liver metastasis. A case report

Cited by 10 publications

References 30 publications

Pancreatic Carcinoma, Thrombosis and Mean Platelet Volume: Single Center Experience from the Southeast Region of Turkey

Pancreatic Carcinoma, Thrombosis and Mean Platelet Volume: Single Center Experience from the Southeast Region of Turkey

Macrovascular venous invasion of pancreatic neuroendocrine tumours: impact on surgical outcomes and survival

Hemostatic Abnormalities in Cirrhosis and Tumor-Related Portal Vein Thrombosis

Contact Info

Product

Resources

About