Pancreatic enzyme activity in the bile of healthy cats and its association with biliary morphology

Fujimoto, Sanji; Torisu, Shidow; Kaneko, Yasuyuki; Mizutani, Shinjiro; Yamamoto, Shushi; Naganobu, Kiyokazu; Nakamura, Kensuke

doi:10.1111/jvim.16196

Cited by 3 publications

(4 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This conclusion is supported by a recent study that evaluated the association between biliary morphology and pancreatic enzyme activity in the bile of healthy cats. 20 This study found that a dilated cystic duct was associated with reflux of pancreatic juice in the bile, which could possibly eventually damage the bile duct epithelium and lead to cholangitis. 20 However, additional studies are needed to determine the clinical relevance of this finding.…”

Section: Discussionmentioning

confidence: 83%

“… 20 This study found that a dilated cystic duct was associated with reflux of pancreatic juice in the bile, which could possibly eventually damage the bile duct epithelium and lead to cholangitis. 20 However, additional studies are needed to determine the clinical relevance of this finding. 20 …”

Section: Discussionmentioning

confidence: 83%

“… 19 In fact, “triaditis,” the term used to describe concurrent inflammation of the pancreas, liver, and small intestine, has been reported in 50% to 56% of cats with pancreatitis, and is thought to be, at least in part, associated with the Y‐shaped junction of the common bile duct and main pancreatic duct in this species. 19 , 20 …”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Abdominal ultrasound and clinicopathologic findings in 22 cats with exocrine pancreatic insufficiency

Auger

Fazio

Steiner

et al. 2021

Veterinary Internal Medicne

View full text Add to dashboard Cite

Background Awareness of exocrine pancreatic insufficiency (EPI) in cats has increased since the development of an assay for feline trypsin‐like immunoreactivity (fTLI). Ultrasound findings in cats with EPI have only been reported rarely and described as nonspecific. Hypothesis/Objectives To describe the ultrasonographic findings, clinical signs, and concurrent diseases in cats with EPI. Animals Twenty‐two client‐owned cats with EPI. Methods Multicenter retrospective descriptive study including cats with serum fTLI concentration ≤8 μg/L and an abdominal ultrasound examination performed within 6 weeks of fTLI measurement. Sonographic measurements of maximal pancreatic thickness and maximal pancreatic duct diameter as well as ratios of pancreatic duct diameter to pancreatic thickness were obtained. Additional sonographic findings, concurrent conditions, and clinical signs were recorded. Results The most common clinical sign was weight loss (15/22 cats). Chronic enteropathy was the most common concurrent disease (13/22 cats). In 39% of cats, the pancreas had minimal or no sonographic alterations. Pancreatic duct dilatation (>2.5 mm), pancreatic duct tortuosity with variable diameter, or both were seen in 6/13 cats. The pancreatic parenchyma was subjectively thin in 6 cats. A significant relationship was found between subjectively thin pancreatic parenchyma and increased pancreatic duct size : pancreatic thickness ratio (P = .004). Diffuse gastrointestinal dilatation with echogenic content was observed in 8/22 cats. Conclusion Exocrine pancreatic insufficiency often causes minimal to no sonographic pancreatic changes. Nonetheless, the findings of thin pancreatic parenchyma, pancreatic duct dilatation, or diffuse small intestinal dilatation with echogenic contents in cats with unexplained weight loss or unformed feces should raise clinical suspicion for EPI.

show abstract

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 83%

See 1 more Smart Citation

Abdominal ultrasound and clinicopathologic findings in 22 cats with exocrine pancreatic insufficiency

Auger

Fazio

Steiner

et al. 2021

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…20 –24 One report in humans proposed that patients with anomalous GB morphology were prone to inflammation and, in particular, formation of choleliths; 25 a 2021 paper in veterinary medicine suggested that biliary morphology may play a role in facilitating pancreatic juice regurgitation. 26 Therefore, some controversy over the clinical relevance of GB morphologic anomalies remains and must be further investigated in the veterinary literature.…”

Section: Discussionmentioning

confidence: 99%

Ultrasonographic prevalence and proposed morphologic classification of bilobed gallbladder in cats

Spain¹,

Penninck

Thelen

2021

Journal of Feline Medicine and Surgery

View full text Add to dashboard Cite

Objectives Morphologic anomalies of the feline gallbladder (GB) have been previously reported in the literature. These morphologic variants are frequently encountered on routine abdominal ultrasound examination. The aim of this study was to provide an ultrasonographic classification system of these variants and document the overall incidence in the feline population. Methods A prospective, descriptive study was undertaken; cats that had an abdominal ultrasound examination that included at least one sagittal and transverse plane image of the GB were included. GB shape was evaluated and categorized based on a classification scheme of morphologic variants modified from the human literature. Septated (S), bilobed (B1, B2, B3), duplex (D) and complex (C) categories were described. Results Of 516 cats included in the study, 389 had normal GB morphology, while 127 had anomalous GB morphology. The overall incidence rate of anomalous GB morphology was 24.61%. When examined by morphologic type, the septated (S) morphology had an incidence of 9.69%. A bilobed (B) morphology was the most commonly observed classification; incidence was 14.35% within our population; incidence of B1, B2 and B3 subtypes were 2.91%, 6.98% and 4.46%, respectively. Duplex GBs only made up 0.39% of the total population. The incidence of complex (C) morphologies was 0.19%. Conclusions and relevance The incidence of GB morphologic anomalies was higher in our population than previously reported. Identification of these anomalies on routine ultrasound evaluation is common; numerous different morphologies can be identified and a standardized classification scheme is proposed. Complete evaluation of morphology can be challenging, particularly with regard to cystic duct anatomy. Clinical significance is uncertain and future studies are warranted to determine the relationship between morphologic variants and hepatobiliary disease.

show abstract

1,2,3-triazole clubbed and dichloro substituted novel aurones as potential anticancer agents targeting digestive enzymes: Design, synthesis, DFT, ADME and molecular docking studies

Kumar,

Saroha,

Arya

et al. 2025

Journal of Molecular Structure

View full text Add to dashboard Cite

Pancreatic enzyme activity in the bile of healthy cats and its association with biliary morphology

Cited by 3 publications

References 29 publications

Abdominal ultrasound and clinicopathologic findings in 22 cats with exocrine pancreatic insufficiency

Abdominal ultrasound and clinicopathologic findings in 22 cats with exocrine pancreatic insufficiency

Ultrasonographic prevalence and proposed morphologic classification of bilobed gallbladder in cats

1,2,3-triazole clubbed and dichloro substituted novel aurones as potential anticancer agents targeting digestive enzymes: Design, synthesis, DFT, ADME and molecular docking studies

Contact Info

Product

Resources

About