Pancreatic fat infiltration, β-cell function and insulin resistance: A study of the young patients with obesity

Wen, Yue; Chen, Cen; Kong, Xiaodong; Xia, Zefeng; Kong, Wen; Si, Keke; Han, Ping; Liu, Weiyin Vivian; Li, Xin

doi:10.1016/j.diabres.2022.109860

Cited by 16 publications

(8 citation statements)

References 41 publications

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“…In contrary to our results Lee et al 18 found that there is no differences between fatty pancreas and non-fatty pancreas group as regard FPG and this can be explained by early diagnosis of fatty pancreas so that β cell function was still preserved or slightly affected as the authors don't assess the β cell function, they only measure HOMA-IR as a measure of insulin resistance. Yu Wen et al 19 who reported that the associations of pancreatic fat fraction with β-cell function and glucose levels were present only in type 2 diabetes mellitus group not in non-type 2 diabetes mellitus group.…”

Section: Discussionmentioning

confidence: 99%

Fatty pancreas: an initial indicator of ectopic fat deposition and metabolic syndrome

Rizk

Lymon

Hafez

et al. 2022

Preprint

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BACKGROUND: Pancreatic steatosis is fat accumulation in the pancreatic gland without fat replacement, this excessive pancreatic lipid content may enter a continuous vicious cycle of hydrolysis and fatty acid re-esterification thereby generating toxic intermediates, which may induce β-cell dysfunction and apoptosis. Several studies were made to study whether these fat depositions are harmful or inert. This study aimed to assess the implications of fat deposition in pancreas on pancreatic β-cell functions in obese patients. SUBJECTS AND METHODS: We included 200 obese female subjects with BMI ≥30 kg/m2 and age (25-50 years) who visited an obesity clinic in Mansoura Specialized Medical hospital after exclusion of any medical conditions or taking drugs which affect lipid metabolism or beta cell function. The subjects were further subdivide fatty pancreatic group including 136 female subjects with ages range from 25 to 52 years old and non-fatty pancreatic group including 64 female subjects with ages range from 23 to 45 years old. All subjects were subjected to anthropometric measurement including height, weight, BMI, WC and laboratory investigations including lipid profile and HBA1C, oral glucose tolerance with measurement of glucose and insulin at 0,30,60 and 120 minutes with calculation of insulin sensitivity and resistance indices. RESULTS: We found that a significant increase in BMI, WC, total cholesterol, LDL-C,TG and glucose and a significant decrease in HDL-C in fatty pancreas group compared to non-fatty pancreas group. Fatty pancreas had negative correlation with β cell functions in the form of decrease insulin secretion and decrease in insulin sensitivity in the form of decrease DI and IGI and increase in HOMA-IR. We found also no relation between fatty liver and fatty pancreas.

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Section: Discussionmentioning

confidence: 99%

Fatty pancreas: an initial indicator of ectopic fat deposition and metabolic syndrome

Rizk

Lymon

Hafez

et al. 2022

Preprint

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“…Although it is widely accepted that T2DM commonly coexists with IPFD [12], the physiopathological infuence of IPFD remains controversial. Some studies found that IPFD was signifcantly associated with insulin resistance and β-cell function [13][14][15]; however, others hold a negative view [6,[16][17][18]. A recent study demonstrated that lipid droplet accumulation in β cells was associated with insulin resistance in T2DM individuals [19].…”

Section: Discussionmentioning

confidence: 99%

Association between Intrapancreatic Fat Deposition and Lower High-Density Lipoprotein Cholesterol in Individuals with Newly Diagnosed T2DM

Wang

Cai

et al. 2023

International Journal of Endocrinology

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Background. Intrapancreatic fat deposition (IPFD) usually occurs in individuals with type 2 diabetes mellitus (T2DM), but its physiopathological influence remains controversial. The present study aimed to investigate IPFD and its associations with various aspects of glucose and lipid metabolism in individuals with newly diagnosed T2DM. Methods. A total of 100 individuals were included, consisting of 80 patients with newly diagnosed T2DM and 20 age- and sex-matched healthy controls. Then, we assessed IPFD using magnetic resonance imaging (MRI) and various parameters of glucose and lipid metabolism. Results. Individuals with newly diagnosed T2DM had a significantly higher IPFD (median: 12.34%; IQR, 9.19–16.60%) compared with healthy controls (median: 6.35%; IQR, 5.12–8.96%) p < 0.001 . In individuals with newly diagnosed T2DM, IPFD was significantly associated with FINS and HOMA-IR in unadjusted model (β = 0.239, p = 0.022 ; β = 0.578, p = 0.007 , respectively) and adjusted model for age and sex (β = 0.241, p = 0.022 ; β = 0.535, p = 0.014 , respectively), but these associations vanished after adjustment for age, sex, and BMI. The OR of lower HDL-C for the prevalence of high IPFD was 4.22 (95% CI, 1.41 to 12.69; p = 0.010 ) after adjustment for age, sex, BMI, and HbA1c. Conclusions. Lower HDL-C was an independent predictor for a high degree of IPFD.

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“…Lipids, including triglycerides, cholesterol, and free fatty acids (FFAs), play essential roles as energy substrates and signaling molecules in cellular metabolism [ 80 ]. However, excessive lipid accumulation, particularly in non-adipose tissues such as skeletal muscle, liver, and pancreatic β-cells, can lead to cellular dysfunction and insulin resistance [ 81 ]. Lipid accumulation and lipotoxicity contribute to insulin resistance in several ways.…”

Section: Mechanisms Of Insulin Resistancementioning

confidence: 99%

Positive Effects of Physical Activity on Insulin Signaling

Małkowska

2024

CIMB

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Physical activity is integral to metabolic health, particularly in addressing insulin resistance and related disorders such as type 2 diabetes mellitus (T2DM). Studies consistently demonstrate a strong association between physical activity levels and insulin sensitivity. Regular exercise interventions were shown to significantly improve glycemic control, highlighting exercise as a recommended therapeutic strategy for reducing insulin resistance. Physical inactivity is closely linked to islet cell insufficiency, exacerbating insulin resistance through various pathways including ER stress, mitochondrial dysfunction, oxidative stress, and inflammation. Conversely, physical training and exercise preserve and restore islet function, enhancing peripheral insulin sensitivity. Exercise interventions stimulate β-cell proliferation through increased circulating levels of growth factors, further emphasizing its role in maintaining pancreatic health and glucose metabolism. Furthermore, sedentary lifestyles contribute to elevated oxidative stress levels and ceramide production, impairing insulin signaling and glucose metabolism. Regular exercise induces anti-inflammatory responses, enhances antioxidant defenses, and promotes mitochondrial function, thereby improving insulin sensitivity and metabolic efficiency. Encouraging individuals to adopt active lifestyles and engage in regular exercise is crucial for preventing and managing insulin resistance and related metabolic disorders, ultimately promoting overall health and well-being.

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Pancreatic fat infiltration, β-cell function and insulin resistance: A study of the young patients with obesity

Cited by 16 publications

References 41 publications

Fatty pancreas: an initial indicator of ectopic fat deposition and metabolic syndrome

Fatty pancreas: an initial indicator of ectopic fat deposition and metabolic syndrome

Association between Intrapancreatic Fat Deposition and Lower High-Density Lipoprotein Cholesterol in Individuals with Newly Diagnosed T2DM

Positive Effects of Physical Activity on Insulin Signaling

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