Pancreatic function after normothermic ischemia

Cerra, F B; Adams, J.R.; D, Eggert; Eilert, John B.; Bergan, John J.

doi:10.1016/s0002-9610(70)80037-x

Cited by 18 publications

(3 citation statements)

References 6 publications

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“…If this effect were due purely to the transient effects of ischaemic cell membrane damage, then a return to normal would be expected within a few days of transplantation, as in the series of dogs with ischaemic nontransplanted pancreases described by Cerra et al (1970). In our series, however, the hyperinsulinaemia appeared to be permanent, the sole difference (apart from the species) being that the gland was denervated during the removal of the organ from the donor.…”

Section: Survivalmentioning

confidence: 53%

Glucose and Insulin Metabolism after Pancreatic Transplantation

Sells¹,

Calne²,

Hadjiyanakis³

et al. 1972

BMJ

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Section: Survivalmentioning

confidence: 53%

Glucose and Insulin Metabolism after Pancreatic Transplantation

Sells¹,

Calne²,

Hadjiyanakis³

et al. 1972

BMJ

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“…However, three of six rats transplanted with organs preserved at 22°C without photosynthesis became hyperglycemic (glucose concentration ≥ 180 mg/dL). Plasma insulin levels were not examined in the present study, but early hyperinsulinism caused by irreversible ischemia/reperfusion injury of grafts indicates poor outcomes such as death attributable to hypoglycemia [14,15]. We postulated that the cause of the death after transplantation is attributable to ischemic damage that causes early high insulin release from a non-functioning pancreas and subsequent hypoglycemia.…”

Section: Resultsmentioning

confidence: 99%

Organ preservation using a photosynthetic solution

et al. 2012

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BackgroundOrgans harvested from a body lapsing into circulatory deficit are exposed to low O2/high CO2, and reach a critical point where original functionality after transplantation is unlikely. The present study evaluates the effect of respiratory assistance using Chlorella photosynthesis on preservation of the rat pancreas from the viewpoint of donation after cardiac death (DCD).MethodsGas was exchanged through the peritoneum of rats under controlled ventilation with or without Chlorella photosynthetic respiratory assistance. A gas permeable pouch containing Chlorella in solution was placed in the peritoneum and then the space between the pouch and the peritoneum was filled with an emulsified perfluorocarbon gas carrier. Rat DCD pancreases procured 3 h after cardiac arrest were preserved for 30 min in a cold or mildly hypothermic environment or in a mildly hypothermic environment with photosynthetic respiratory support. The pancreases were then heterotopically transplanted into rats with STZ-induced diabetes.ResultsLevels of blood oxygen (PaO2) and carbon dioxide (PaCO2) increased and significantly decreased, respectively, in rats with mechanically reduced ventilation and rats given intraperitoneal photosynthetic respiratory support when compared with those without such support. Transplantation with DCD pancreases that had been stored under photosynthetic respiratory support resulted in the survival of all rats, which is impossible to achieve using pancreases that have been maintained statically in cold storage.ConclusionRespiratory assistance using photosynthesis helps to improve not only blood gas status in the event of respiratory insufficiency, but also graft recovery after pancreas transplantation with a DCD pancreas that has been damaged by prolonged warm ischemia.

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“…Το μόσχευμα μετά του σπληνός, πνευμόνων καί ήπατος εστάλησαν προς ίστολογικήν έξέτασιν το αποτέλεσμα τής οποίας εμφαίνεται εϊς τάς εικόνας (11,12,13,14).…”

Section: όμάς γ'unclassified

Μεταβολαι Της Σακχαραιμικης Καμπυλης Επι Ορθοτοπικης Και Ετεροτοπικης Μεταμοσχευσεως Του Παγκρεατος. (Πειραματικη Μελετη)

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Pancreatic function after normothermic ischemia

Cited by 18 publications

References 6 publications

Glucose and Insulin Metabolism after Pancreatic Transplantation

Glucose and Insulin Metabolism after Pancreatic Transplantation

Organ preservation using a photosynthetic solution

Μεταβολαι Της Σακχαραιμικης Καμπυλης Επι Ορθοτοπικης Και Ετεροτοπικης Μεταμοσχευσεως Του Παγκρεατος. (Πειραματικη Μελετη)

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