2015
DOI: 10.14814/phy2.12443
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Pancreatic functions in high salt fed female rats

Abstract: Salt consumption has been increased worldwide and the association of high salt diets with enhanced inflammation and target organ damage was reported. Little data were available about the effect of high salt diet on exocrine function of pancreas, while the relation between high salt intake and insulin sensitivity was controversial. This study was designed to investigate the effect of high salt diet on exocrine and endocrine pancreatic functions, and to elucidate the possible underlying mechanism(s). Twenty adul… Show more

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Cited by 12 publications
(8 citation statements)
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References 52 publications
(55 reference statements)
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“…The result defines the nutritional status, called the Lee index, which correlates positively with adipose tissue mass. [74,75]. In this study, the values obtained from this index reveal a slight, but significant, increase in the IF group values compared to the control group ( Figure 2D), which does not mean that the IF animals are obese, but corroborates the largest adipose reserve found ( Figure 4A-D).…”
Section: Discussionsupporting
confidence: 44%
“…The result defines the nutritional status, called the Lee index, which correlates positively with adipose tissue mass. [74,75]. In this study, the values obtained from this index reveal a slight, but significant, increase in the IF group values compared to the control group ( Figure 2D), which does not mean that the IF animals are obese, but corroborates the largest adipose reserve found ( Figure 4A-D).…”
Section: Discussionsupporting
confidence: 44%
“…Glucose concentrations were measured by the glucose oxidase method (enzymatic glucose, ANALISA Diagnóstica, Belo Horizonte, MG, Brazil), and insulinemia was measured by enzyme‐linked immunosorbent assays (ELISA) (Sensitive Rat Insulin, SRI‐13K, Millipore, St. Charles, MO). Insulin resistance was evaluated by the homeostasis model assessment of insulin resistance (HOMA‐IR) index, which was calculated according to the following formula: HOMA‐IR = fasting glycemia (mmol/L) × fasting insulinemia (µIU/mL)/22.5 …”
Section: Methodsmentioning
confidence: 99%
“…Due to ROS overproduction, excessive salt intake worsens hepatic lipid peroxidation and accelerates high-fat induced nonalcoholic fatty liver disease and nonalcoholic steatohepatitis [36][37][38]. Additionally, a chronic exposure of HSD is indicated to cause pancreatic fibrosis in Wistar rats [39]. Studies also revealed that an HSD might get involved in gastroesophageal reflux [40], pancreatic cancer, and esophageal cancer [41][42][43]; however, more mechanism-revealing studies are needed (Table 1).…”
Section: Hsd and The Gi Disordersmentioning
confidence: 99%