Pancreatic hamartoma: detection of harbouring NAB2::STAT6 fusion gene

Abstract

Conclusion:Of the 13 patients histopathologically diagnosed with hamartoma, two demonstrated NAB2::STAT6 fusions, suggesting the existence of pancreatic hamartomas with molecular-level components identical to those of SFT.

Pancreatic hamartoma: Possibility of a preoperative diagnosis via endoscopic ultrasound–guided fine‐needle aspiration biopsy

“…In our patient, CD34 expression in the stromal cells further evinced the diagnosis of pancreatic hamartoma. Recently, STAT6 expression was reported in the nuclei of the intervening spindle cells of pancreatic hamartoma, although it was negative in our patient 8 …”

“…Recently, STAT6 expression was reported in the nuclei of the intervening spindle cells of pancreatic hamartoma, although it was negative in our patient. 8 The preoperative EUS-FNAB specimen of our patient contained the pancreatic hamartoma lesion. The specimen contained scattered small ducts embedded in fibrous stroma, a finding consistent with hamartoma.…”

“…Pancreatic hamartoma is a very rare, non‐neoplastic, mass‐forming pancreatic lesion, 1 with only 64 cases reported in the English literature and 7 in the Japanese literature, without abstract only (based on literature searches using the PubMed and Japanese Ichushi databases) 1–51 . As pancreatic hamartoma is typically asymptomatic, in more than half the abovementioned reports, the cases has been incidentally discovered 1–51 . Furthermore, preoperative diagnosis using various techniques, such as CT, MRI, or US, is extremely difficult because various neoplasms, such as NET, solid pseudopapillary neoplasm, and adenocarcinoma, are included in the differential diagnosis, as described in the case report and literature review by Noguchi et al 1 In our case, the imaging findings suggested NET, although some features were atypical.…”

“…Our case shows that pancreatic hamartoma can be preoperatively diagnosed using EUS–FNAB. Pancreatic hamartoma is a very rare, non‐neoplastic, mass‐forming pancreatic lesion, 1 with only 64 cases reported in the English literature and 7 in the Japanese literature, without abstract only (based on literature searches using the PubMed and Japanese Ichushi databases) 1–51 . As pancreatic hamartoma is typically asymptomatic, in more than half the abovementioned reports, the cases has been incidentally discovered 1–51 .…”

Are Solitary Fibrous Tumors of the Pancreas the Same Tumor as Pancreatic Hamartomas?

“…The authors mentioned desmoid tumor/fibromatosis, inflammatory myofibroblastic tumors, schwannomas, gastrointestinal stromal tumors, leiomyomas, melanomas, well-differentiated pancreatic neuroendocrine tumors, and sclerosing epithelioid mesenchymal tumors. However, pancreatic hamartoma, which was not mentioned in the paper, is another important differential diagnosis of SFT of the pancreas 2–4 . Pancreatic hamartoma is a rare tumor (or tumor-like lesion) characterized by mature acini and small-sized to medium-sized ducts with a distorted architecture, often accompanied by various amounts of fibrous stroma 2 .…”