Pancreatic Injury after COVID-19 Vaccine—A Case Report

Cieślewicz, Artur; Dudek, Magdalena; Krela‐Kaźmierczak, Iwona; Jabłecka, Anna; Lesiak, Maciej; Korzeniowska, Katarzyna

doi:10.3390/vaccines9060576

Cited by 37 publications

(49 citation statements)

References 13 publications

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“…Walter et al reported a case of acute necrotizing pancreatitis 10 h after the administration of the second dose of Pfizer-BioNTech COVID-19 mRNA vaccine in a 43-year-old male [ 13 ]. Cieslewicz reported a case of AP injury 20 h after Pfizer-BioNTech COVID-19 mRNA vaccination in a 29-year-old female [ 14 ]. As in the latter two cases, our patient presented mild AP shortly after receiving the vaccination without signs or symptoms of an allergic reaction.…”

Section: Discussionmentioning

confidence: 99%

Acute Mild Pancreatitis Following COVID-19 mRNA Vaccine in an Adolescent

et al. 2021

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A 17-year-old male was referred to the emergency room with sharp abdominal pain, pallor, sweating, and vomiting 12 h after the administration of his first Pfizer-BioNTech vaccine for coronavirus disease 2019 (COVID-19). He had abdominal pain, an increase in serum lipase value of > 3 times the upper limits of normal, and magnetic resonance imaging (MRI) findings consistent with acute mild pancreatitis (AP). He was started on treatment with fluid therapy and non-steroidal anti-inflammatory drugs for pain management, after which he recovered rapidly and was discharged on the fourth day after hospitalization. The available data are difficult to interpret as AP is a relatively frequent disease, but its occurrence after vaccination seems extremely rare. Although it is a rare event, AP should be considered after COVID-19 vaccination, especially in those exhibiting abdominal tenderness and vomiting, which should be promptly treated and adequately investigated.

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Section: Discussionmentioning

confidence: 99%

Acute Mild Pancreatitis Following COVID-19 mRNA Vaccine in an Adolescent

et al. 2021

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“…Considerable expression of ACE2 in human pancreatic islets has been reported. In patients with severe COVID-19, the expression of ACE2 inside the pancreas at some levels can cause acute inflammation which prompted acute pancreatitis [16].…”

Section: Underlying Pathogenesis Of Pancreatic Injurymentioning

confidence: 99%

Pancreatic Injury and Coronavirus Disease-2019

Siregar

Zain

Lubis

et al. 2021

Open Access Maced J Med Sci

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BACKGROUND: Coronavirus disease 2019 can induce dysfunction in a couple of organs, including kidney, heart, liver, gut, and pancreas. Pancreatic injury is an inflammatory situation of the exocrine pancreas, precipitated mostly by gallstones and alcohol intake. We found the fact that lack of research about the influence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in pancreatic injury. METHODS: A literature searching was conducted through the PubMed, Science Direct, Medline, and Google Scholar searching engines using the following keywords: (“severe acute respiratory tract syndrome-coronavirus 2019” OR “COVID-19” OR “coronavirus 2019” OR “SARS-CoV-2”) AND (“pancreas” OR “pancreatitis” OR “hyperamylasemia” OR “pancreatic injury” OR “pancreatic damage” OR “pancreatic disturbance”). All articles and abstracts in English from literature review, case report, original article, systematic review, and meta-analysis were involved. RESULTS: A total of 17 literatures were gathered. Through the studies, we found that several pathways may damage pancreas in coronavirus disease 2019 (COVID-19) patients, either due to direct virus-mediated damage of the exocrine pancreas via the angiotensin converting enzyme 2 receptors, the severe COVID-19 contamination which can lead to systemic inflammation and pancreatic injury, or the virus-mediated injury to the islet cells. The prevalence of pancreatitis in patients with COVID-19 was low. Elevated pancreatic enzyme level was one of the sign of pancreatic involvement. CONCLUSION: Pancreatic injury may occur in patients with severe COVID-19 due to several pathways. Assessment of pancreatitis severity may aid in managing pancreatitis in this particular population.

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“…Post-authorization monitoring has proven that adenoviral vector and mRNA-based vaccines are generally safe. However, various rare side effects were reported, including myocarditis, pericarditis [ 5 , 6 ], appendicitis [ 7 ], liver [ 8 ], pancreatic [ 9 ] and kidney injuries [ 10 ], and thrombotic thrombocytopenia [ 11 , 12 ]. The exact mechanisms behind these events require further investigations, although several potential explanations were offered [ 5 , 13 – 15 ].…”

Section: Introductionmentioning

confidence: 99%