Pancreatic intraepithelial neoplasia‐3 arising from ectopic pancreas in the jejunum

Niino, Daisuke; Yasumoto, Makiko; Ishibashi, Yukinao; Ozaki, Kunihiro; Baba, Kenkichi; Nakashima, Tomomi; Yamano, Kanako; Ohshima, Koichi; Sugita, Yasuo

doi:10.1111/pin.12132

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…There are case reports highlighting dysplastic changes and malignant transformation of heterotopic pancreatic tissue in the literature, but it is very rare. 1 We report a case of gastric heterotopic pancreas, which presented with abdominal pain and was challenging to classify due to low grade dysplasia of the ducts.…”

mentioning

confidence: 99%

Gastric heterotopic pancreas with low grade dysplasia of the ducts

Boyacı

Paşaoğlu

Okçu³

et al. 2016

Pathology International

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mentioning

confidence: 99%

Gastric heterotopic pancreas with low grade dysplasia of the ducts

Boyacı

Paşaoğlu

Okçu³

et al. 2016

Pathology International

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Heterotopic Pancreas of the Gastrointestinal Tract and Associated Precursor and Cancerous Lesions

Jun

Son²,

Kim

et al. 2017

American Journal of Surgical Pathology

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Heterotopic pancreas (HP) can be detected by accompanying symptoms or incidentally during gastrointestinal (GI) tract tumor resection. We compared clinicopathologic features among 165 resected HPs (57 gastric [35%], 56 duodenal [34%], 30 omental [18%], and 22 jejunal [13%]). Symptomatic HPs (79/135 GI tract wall HPs, 59%) were larger (P=0.05), more common in younger patients and in a gastric location (both P<0.001), and more frequently associated with lymphoid cuffs (P=0.03) than incidentally found HPs. Gastric/jejunal HPs were more frequently symptomatic (P<0.001), deeply located (P=0.03), and associated with lymphoid cuffs (P=0.008) and pancreatic intraepithelial neoplasia/intraductal papillary mucinous neoplasms (PanIN/IPMN; P=0.001) than duodenal HPs. HP was frequently associated with acinar-ductal metaplasias (117/135 GI tract wall HPs, 87%) and PanINs/IPMNs (68/135, 50%); those with PanINs/IPMNs were larger (P<0.001), more frequently located in stomach (P=0.001), had deeper wall involvement (P=0.03), and more often showed infiltrative growth (P<0.001) and lymphoid cuffs (P=0.02). Four HPs containing PanINs abutted adenocarcinomas, all expressing wild-type KRAS and intact SMAD4/DPC4 expression. Thus, symptomatic HP is associated with younger age, larger size, gastric location, and lymphoid cuffs. HPs containing PanINs/IPMNs (usually low grade) are larger and more common in stomach, have deeper wall location, and show infiltrative growth and lymphoid cuffs. Adenocarcinomas are rarely observed adjacent to HPs with PanINs/IPMNs. KRAS mutational and SMAD4/DPC4 immunohistochemical studies can discriminate between adenocarcinoma derived from HP and concurrent adenocarcinoma with HP.

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Ductal Adenocarcinoma and Pancreatic Intraepithelial Neoplasia

2023

Tumors of the Pancreas

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Pancreatic intraepithelial neoplasia‐3 arising from ectopic pancreas in the jejunum

Cited by 3 publications

References 6 publications

Gastric heterotopic pancreas with low grade dysplasia of the ducts

Gastric heterotopic pancreas with low grade dysplasia of the ducts

Heterotopic Pancreas of the Gastrointestinal Tract and Associated Precursor and Cancerous Lesions

Ductal Adenocarcinoma and Pancreatic Intraepithelial Neoplasia

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