Pancreatic Metastases as the Initial Manifestation of a Neuroendocrine Carcinoma of the Uterine Cervix

Tulio, M; Horta, Mariana; Bispo, Miguel; Costa, Tiago Silva; Chagas, Cristina

doi:10.1097/mpa.0000000000000979

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Even though management guidelines for rare metastases in patients with NENs have been published, to date a comprehensive description and survival analysis of PMs is sparse including mostly case reports. [8,9] Our study provided comprehensive data from a relatively large cohort of NEN patients with PMs and evaluated the prognostic value of these rare metastatic lesions as well as their effect on OS of patients harbouring them.…”

Section: Discussionmentioning

confidence: 99%

“…There are only a few case reports of patients with NENs of the gastrointestinal tract and the uterine with PMs. [8,9] In addition, a study that reviewed autopsy records of 103 cases with pancreatic secondary tumours from 690 cases of malignant tumours (excluding cases of primary pancreatic cancer) reported that only five had PMs of a NEN with the primary being the stomach in two cases and the gallbladder, the extrahepatic bile duct and the ureter in the remaining three cases. [10] Thus, the prevalence of PMs as well as the clinical course, outcome and optimal management of patients with NENs and PMs are largely unknown.…”

Section: Introductionmentioning

confidence: 99%

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Pancreatic metastases in patients with neuroendocrine neoplasms: A multi‐centre cohort study

Tsoli

Daskalakis

Wedin

et al. 2023

J Neuroendocrinology

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Pancreatic metastases (PMs) from neuroendocrine neoplasms (NENs) are rare but the increased sensitivity of new diagnostic tools such as 68 Ga-DOTATATE PET/CT has resulted in their increased recognition at initial diagnosis or follow-up.A retrospective analysis of the data of patients from six tertiary referral centres was performed in order to identify the characteristics and the prognostic significance of PMs in patients with NENs. We used a control group of 69 age-, sexand primary tumourmatched NEN patients from the same cohort with stage IV disease but no PMs. Overall survival (OS) was assessed using the Kaplan-Meier method log-rank analysis was used to assess the impact of various clinical and histopathological variables in OS. We identified 25 patients (11 females) with PMs with a median age at diagnosis of 60 years. The small intestine was the most common primary (80%) with a prevalence of 4.2% PMs (21/506). Fourteen patients presented with synchronous PMs whereas 11 developed metachronous PMs after a median time of 28 months (range: 7-168 months). Grading was available in 24 patients; 16 patients had G1 tumours, four G2, two atypical lung carcinoid, one typical and one atypical thymic carcinoid. Most patients had other concomitant metastases (12 hepatic, 4 lung and 6 bone) while five patients exhibited peritoneal carcinomatosis. Median OS in the PMs group was not reached compared with 212 months in the control group (95% CI: 26-398). The univariate analysis identified no prognostic factors statistically significantly associated with the OS. In conclusion, PMs are encountered with a low prevalence among NEN patients mostly developing in patients with advanced metastatic disease. The presence of PMs does not seem to be associated with a negative prognostic impact in OS.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pancreatic metastases in patients with neuroendocrine neoplasms: A multi‐centre cohort study

Tsoli

Daskalakis

Wedin

et al. 2023

J Neuroendocrinology

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Small-cell neuroendocrine carcinoma of the uterine cervix with pancreatic metastasis: a case report and a review of the literature

Lee

Hwang

Kim

2019

Journal of Obstetrics and Gynaecology

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Metastasesin the pancreas: radiation methods assessment of cryodestruction

Гальчина¹,

Карельская²,

Кармазановский

et al. 2021

Medicinskaâ vizualizaciâ

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Metastases in the pancreas are rather rare tumor lesion of this organ. According to different data, the incidence of metastatic pancreatic lesions varies from 1.8 to 4% of all pancreatictumors.The article presents three clinical observations of metastases of melanoma, renal clearcell cancer, lung cancer in the pancreas. All patients were treatedusing cryosurgical methods with positive dynamics in the postoperative period.A brief review of the literature discussing metastatic lesions of the pancreas is also done, and the management treatment tactics of these patients is described.

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Pancreatic Metastases as the Initial Manifestation of a Neuroendocrine Carcinoma of the Uterine Cervix

Cited by 3 publications

References 9 publications

Pancreatic metastases in patients with neuroendocrine neoplasms: A multi‐centre cohort study

Pancreatic metastases in patients with neuroendocrine neoplasms: A multi‐centre cohort study

Small-cell neuroendocrine carcinoma of the uterine cervix with pancreatic metastasis: a case report and a review of the literature

Metastasesin the pancreas: radiation methods assessment of cryodestruction

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