Pancreatic neuroendocrine tumors (PNETs): incidence, prognosis and recent trend toward improved survival

Halfdanarson, Thorvardur R.; Rabe, Kari G.; Rubin, Joseph; Petersen, Gloria M.

doi:10.1093/annonc/mdn351

Cited by 760 publications

(558 citation statements)

References 23 publications

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“…It was a nonfunctioning tumour of size 12x7x3 cm which had metastasized to the ovary. In a study conducted by Halfdanarson et al [15] mean age of patients with pancreatic NETs was 58.8 years and 60.2% had metastasized. These findings are in agreement with the present study.…”

Section: Discussionmentioning

confidence: 95%

Gastroenteropancreatic Neuroendocrine Tumours – An Institutional Experience

Joseph

2015

Int Jour of Biomed Res

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Objectives: 1) To study the histomorphological spectrum of gastroenteropancreatic neuroendocrine tumours (GEP NETs) and to analyze it`s clinicopathological features. 2) To classify the GEP-NETs as per WHO 2010 classification system. 3) To analyze the expression of the NET marker Neuron specific enolase (NSE) in the above histomorphological spectrum. Methods: A retrospective study was done with collected cases of GEP-NET (over 7 year period). Clinical data was collected from medical records. The histopathology slides were retrieved from archives and reviewed. Immunohistochemical (IHC) studies were done with marker NSE. Results: The study included 11 cases of GEP-NETs. The age of the patients ranged from 13 to 65 years. The most common anatomic location was the appendix and colon with 3 cases each (27.27%). Most of the tumours were grade I (6 cases). None of the tumours were associated with carcinoid syndrome. Six out of eleven cases had metastasis at time of diagnosis (54.54%). IHC studies done with NSE resulted in positivity seen in all 10 cases in which it was done. Conclusions: Gastroenteropancreatic neuroendocrine tumours are rare and occur over a wide age range. Most of these tumours present late with metastasis at time of diagnosis. The most common location of these tumours was in the appendix and proximal colon. NSE is a good marker for these tumours and is beneficial in confirming the diagnosis.

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Section: Discussionmentioning

confidence: 95%

Gastroenteropancreatic Neuroendocrine Tumours – An Institutional Experience

Joseph

2015

Int Jour of Biomed Res

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“…13 Many small NF-PNETs are discovered incidentally on cross-sectional imaging (CT/MRI) which is being performed more frequently nowadays. 2,14 Recently, the H. Lee Moffitt Cancer Center concluded that 40% of PNETs were discovered incidentally and 55% of tumors were in stage I according to American Joint Committee on Cancer (AJCC) classification. 15 The WHO classification of PNETs was updated in 2010.…”

Section: Discussionmentioning

confidence: 99%

Behavior of small, asymptomatic, nonfunctioning pancreatic neuroendocrine tumors (NF-PNETs)

Lee

Jung

2014

Pancreatology

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“…Compared with PDA, however, the prognosis is usually much better, with approximately 40 % of affected patients surviving 10 years after diagnosis [126][127][128]. PanNETs are heterogeneous and clinically can be divided into functioning (syndromic) or nonfunctioning (nonsyndromic) tumors.…”

Section: Pancreatic Neuroendocrine Tumorsmentioning

confidence: 99%

The genetic classification of pancreatic neoplasia

2015

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Cancer is caused by the accumulation of inherited and/or acquired alterations in specific genes. The recent decline in the cost of DNA sequencing has allowed tumor sequencing to be conducted on a large scale, which, in turn, has led to an unprecedented understanding of the genetic events that drive neoplasia. This understanding, when integrated with meticulous histologic analyses and with clinical findings, has direct clinical implications. The recent sequencing of all of the major types of cystic and noncystic neoplasms of the pancreas has revealed opportunities for molecular diagnoses and for personalized treatment. This review summarizes the results from these recent studies focusing on the clinical relevance of genomic data.

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Pancreatic neuroendocrine tumors (PNETs): incidence, prognosis and recent trend toward improved survival

Abstract: PNETs are uncommon neoplasms but the incidence may be increasing. Age, grade, stage, and functional status predict survival in patients with PNETs. Survival has improved over time, but this is not explained by earlier diagnosis or stage migration.

Cited by 760 publications

References 23 publications

Gastroenteropancreatic Neuroendocrine Tumours – An Institutional Experience

Gastroenteropancreatic Neuroendocrine Tumours – An Institutional Experience

Behavior of small, asymptomatic, nonfunctioning pancreatic neuroendocrine tumors (NF-PNETs)

The genetic classification of pancreatic neoplasia

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