Pancreatic Regeneration: Models, Mechanisms, and Inconsistencies

Socorro, Mairobys; Esni, Farzad

doi:10.3998/panc.2017.03

Pancreapedia: Exocrine Pancreas Knowledge Base

DOI: 10.3998/panc.2017.03

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Pancreatic Regeneration: Models, Mechanisms, and Inconsistencies

Mairobys Socorro¹,

Farzad Esni²

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References 77 publications

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Regeneration of β-cells of the islet apparatus of the pancreas. Literature review

2022

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Diabetes of both type 1 and type 2 is characterized by a progressive loss of β-cell mass, which contributes to the disruption of glucose homeostasis. The optimal antidiabetic therapy would be simple replacement of lost cells, but at present, many researchers have shown that the pancreas (PZ) of adults has a limited regenerative potential. In this regard, significant efforts of researchers are directed to methods of inducing the proliferation of β-cells, stimulating the formation of β-cells from alternative endogenous sources and/or the generation of β-cells from pluripotent stem cells. Factors that regulate β-cell regeneration under physiological or pathological conditions, such as mediators, transcription factors, signaling pathways and potential pharmaceuticals, are also being intensively studied. In this review, we consider recent scientific studies carried out in the field of studying the development and regeneration of insulin-producing cells obtained from exogenous and endogenous sources and their use in the treatment of diabetes. The literature search while writing this review was carried out using the databases of the RSIC, CyberLeninka, Scopus, Web of Science, MedLine, PubMed for the period from 2005 to 2021. using the following keywords: diabetes mellitus, pancreas, regeneration, β-cells, stem cells, diabetes therapy.

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Regeneration of β-cells of the islet apparatus of the pancreas. Literature review

2022

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Pancreatic Regeneration: Models, Mechanisms, and Inconsistencies

Cited by 1 publication

References 77 publications

Regeneration of β-cells of the islet apparatus of the pancreas. Literature review

Regeneration of β-cells of the islet apparatus of the pancreas. Literature review

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