Pancreatic response in healthy dogs fed diets of various fat compositions

James, Fleur; Mansfield, CS; Steiner, Jöerg M.; Williams, David A.; Robertson, Ian D.

doi:10.2460/ajvr.70.5.614

Cited by 33 publications

(43 citation statements)

References 9 publications

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“…A previous study evaluated the effect of various diets on serum PLI concentrations, and dogs fed a diet with a crude fat content of 5% or 16%, dogs fed a diet with a crude fat content of 16% and a pancreatic enzyme supplement, and dogs fed a diet with a crude fat content of 5% and a pancreatic enzyme supplement and medium chain triglyceride oil did not show a significant difference in serum cPLI concentrations. 11 These findings would agree with the findings of the current study. 11 Withholding food in patients prior to sample collection for cPLI analysis may be less important than for measurement of other marker substances.…”

Section: Discussionsupporting

confidence: 93%

“…11 These findings would agree with the findings of the current study. 11 Withholding food in patients prior to sample collection for cPLI analysis may be less important than for measurement of other marker substances. However, it must be stressed that the dogs used in the current as well as the previous study were clinically healthy, and dogs evaluated for a potential diagnosis of pancreatitis may show a different response.…”

Section: Discussionsupporting

confidence: 93%

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Influence of feeding on serum canine pancreatic lipase immunoreactivity concentrations

Steiner

Ruaux

Williams

2014

VMRR

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Measurement of serum concentration of pancreatic lipase immunoreactivity (PLI) has been shown to be highly specific for exocrine pancreatic function and sensitive for the diagnosis of canine pancreatitis. Currently, it is recommended that food be withheld for at least 12 hours before collecting a blood sample for analysis from dogs. However, it is unknown whether feeding has any influence on serum canine PLI concentration. Thus, the goal of this study was to evaluate the influence of feeding on serum canine PLI concentrations in healthy dogs. Food was withheld from eight healthy adult Beagle dogs for at least 17 hours and a baseline serum sample (0 minutes) was collected. Dogs were fed and serum samples were collected at 15, 30, 45, 60, 75, 90, 105, 150, 180, 210, 240, 300, 360, 420, and 480 minutes. There was no significant difference in serum canine PLI concentrations at any time after feeding (P=0.131). We conclude that feeding has no significant influence on serum canine PLI concentrations.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Influence of feeding on serum canine pancreatic lipase immunoreactivity concentrations

Steiner

Ruaux

Williams

2014

VMRR

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“…After study completion, the serum was shipped on dry ice to the Gastrointestinal Laboratory at Texas A&M University for measurement of gastrin concentrations. Serum gastrin concentrations were measured with an automated chemiluminescent, enzyme‐labeled immunometric assay as previously described …”

Section: Methodsmentioning

confidence: 99%

Repeated Famotidine Administration Results in a Diminished Effect on Intragastric pH in Dogs

Tolbert

Graham

Odunayo

et al. 2016

Veterinary Internal Medicne

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BackgroundFamotidine is an acid suppressant commonly administered to dogs. Prolonged famotidine use in people results in decreased efficacy, but the effect in dogs is unknown.Hypothesis/ObjectivesTo compare the effect of repeated oral administration of famotidine or placebo on intragastric pH and serum gastrin in dogs. We hypothesized that famotidine would have a diminished effect on intragastric pH on day 13 compared to day 1.AnimalsSix healthy adult colony Beagles.MethodsRandomized, 2‐factor repeated‐measures crossover design. All dogs received oral placebo or 1.0 mg/kg famotidine q12h for 14 consecutive days. Intragastric pH monitoring was used to continuously record intragastric pH on treatment days 1–2 and 12–13. Mean pH as well as mean percentage time (MPT) that intragastric pH was ≥3 or ≥4 were compared between and within groups by analysis of variance. Serum gastrin was measured on days 0, 3, and 12 for each treatment.ResultsContinued administration of famotidine resulted in a significant decrease in mean pH, MPT ≥3, and MPT ≥4 (P < .0001) on day 12 and 13. This resulted in a mean decrease in pH by 1.63 on days 12 and 13 compared to days 1 and 2. Furthermore, a mean decrease of MPT ≥3 and MPT ≥4 by 33 and 45% was observed for the same time period, respectively.Conclusions and Clinical ImportanceContinued administration of famotidine results in a diminished effect on intragastric pH in dogs. Caution is advised when recommending long‐term, daily oral administration of famotidine to dogs.

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“…Not only did the EFG dogs return to voluntary intake more quickly when food was introduced ( P = 0.05) but they also reached their maximum voluntary intake faster than the DFG dogs. This likely could be a positive influence on voluntary intake as the presence of intraluminal nutrients may stimulate central hunger impulses via complex neurologic signaling pathways …”

Section: Discussionmentioning

confidence: 99%

Retrospective evaluation of the impact of early enteral nutrition on clinical outcomes in dogs with pancreatitis: 34 cases (2010–2013)

Harris

Parnell

Griffith

et al. 2017

J Vet Emergen Crit Care

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Results of the study suggested that feeding within 48 hours of hospitalization for canine pancreatitis has a positive impact on return to voluntary intake and decreases the frequency of GI in these patients, independent of CSIS. The traditional protocol of withholding food during hospitalization may not be necessary nor yield the most benefit for patient recovery; subsequently early enteral refeeding should be considered.

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Pancreatic response in healthy dogs fed diets of various fat compositions

Abstract: Results did not indicate a significant effect of dietary fat content or addition of supplemental MCT oil or pancreatic enzymes in diets on serum cTLI, cPLI, or gastrin concentrations in healthy dogs.

Cited by 33 publications

References 9 publications

Influence of feeding on serum canine pancreatic lipase immunoreactivity concentrations

Influence of feeding on serum canine pancreatic lipase immunoreactivity concentrations

Repeated Famotidine Administration Results in a Diminished Effect on Intragastric pH in Dogs

Retrospective evaluation of the impact of early enteral nutrition on clinical outcomes in dogs with pancreatitis: 34 cases (2010–2013)

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