Pancreatic stellate cells contribute to regeneration early after acute necrotising pancreatitis in humans

The Plasticity of Pancreatic Stellate Cells Could Be Involved in the Control of the Mechanisms that Govern the Neogenesis Process in the Pancreas Gland

“…These observations, plus the identification of the PSC positive for nestin marker, support the idea that this population could be involved in the pancreatic regeneration process (Zimmermann A et al 2002, Ishiwata T et al 2006. (Mato E. et al, unpublished data) …”

The pancreatic stellate cell: a star on the rise in pancreatic diseases

“…In human and rodent pancreatic tissues, activated PaSCs are usually found in areas of extensive necrosis and inflammation where an environment rich in cytokines, growth factors, and reactive oxygen species prevails (56)(57)(58). Time-course studies using several animal models of experimental pancreatitis (59)(60)(61) indicate that parenchymal necrosis and inflammation precede PaSC activation, thereby suggesting that a necrotic, inflammatory process is a prerequisite for activation of these cells. Hence, autocrine and paracrine mediators are probably involved in PaSC activation.…”

Immortalization of pancreatic stellate cells as an in vitro model of pancreatic fibrosis: deactivation is induced by matrigel and N-acetylcysteine

“…[8][9][10][11][12] Moreover, these cells seem to contribute to tissue regeneration after acute necrotizing pancreatitis. 13 In the normal pancreas, stellate cells are quiescent and, like their counterparts in the liver, store vitamin A in lipid droplets in their cytoplasm. 9,14 When exposed to injury, inflammation or after prolonged cultivation in vitro, the cells transform to an activated myofibroblast-like state.…”