2010
DOI: 10.1016/j.bbrc.2010.11.040
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Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells

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Cited by 198 publications
(152 citation statements)
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“…Pancreatic ductal adenocarcinoma is characterized by its high malignant potential, showing rapid progression, early metastasis, and limited response to chemotherapy and radiotherapy (18). The efficacies of adjuvant and neoadjuvant chemotherapy with gemcitabine for pancreatic cancer (7,8) and the induction of apoptotic cell death in vitro by chemotherapy and radiotherapy in malignant tumors (9) were reported.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Pancreatic ductal adenocarcinoma is characterized by its high malignant potential, showing rapid progression, early metastasis, and limited response to chemotherapy and radiotherapy (18). The efficacies of adjuvant and neoadjuvant chemotherapy with gemcitabine for pancreatic cancer (7,8) and the induction of apoptotic cell death in vitro by chemotherapy and radiotherapy in malignant tumors (9) were reported.…”
Section: Discussionmentioning
confidence: 99%
“…Accumulating evidence suggests that pancreatic stromal cells promote the progression and EMT of pancreatic cancer by increasing cancer cell proliferation and invasion as well as by protecting the cells from radiation-and gemcitabineinduced apoptosis (18). There are a number of reports on the induction of chemoresistance linked to EMT and cancer stem cells in vitro.…”
Section: Introductionmentioning
confidence: 99%
“…27 Pancreatic cancer cells (1 Â 10 5 cells) were seeded in six-well plates (BD Biosciences) in 2 ml DMEM supplemented with 10% FBS. Human primary-cultured PSCs (3 Â 10 5 cells) were seeded into 3-mm pore Transwell chambers in 1 ml DMEM with 10% FBS.…”
Section: Matrigel Invasion and Migration Assaysmentioning
confidence: 99%
“…[22][23][24][25][26] A recent report demonstrated that PSCs also promote EMT in pancreatic cancer cells. 27 In this study, we aim to verify whether AGR2 expression represents a useful prognostic marker in human PDAC, and whether its downregulation is mediated by EMT induction. We identified a correlation between AGR2 expression, EMT marker expression, and clinic-pathological parameters in PDAC.…”
mentioning
confidence: 99%
“…It has been shown that cancer-associated fibroblasts or TPSCs can stimulate migration or invasion of cancer cells in vitro, although mainly through 2D models (Hwang et al, 2008, Kikuta et al, 2010). The organotypic model has previously displayed favourable results for visualisation of cancer cell invasion and interplay with the local microenvironment (Froeling et al, 2009, Linde et al, 2012.…”
Section: Discussionmentioning
confidence: 99%