Pancreatic stone protein as a biomarkers for sepsis: a systematic review and meta-analysis

Abstract

Backgroud The attack rate of the sepsis and its mortality is increasing rapidly in the world, with early diagnosis and prognosis being essential. Pancreatic stone protein (PSP) is regarded as an excellent indicator of detecting infection, which demonstrated a good diagnostic and prognostic value in sepsis. We utilized the meta-analysis method to further demonstrate the early diagnosis value and prognostic effectiveness of PSP in sepsis. Methods Relevant literature was systematically searched in PubMed, Ovid, Embase and ScienceDirect databases using medical subject headings and relevant diagnostic terms. All included literature was analysed using Stata 14.0 to calculate outcomes of pooled extracted data such as sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, area under the curve, diagnostic odds ratio and diagnostic score. Publication bias in the included studies was assessed using Deek's funnel plot. Cochrane Q statistic and I2 statistic were used to test for heterogeneity. Results A total of 12 studies were included in this analysis and the literature was divided into three groups based on the type of study: the ability of PSP to diagnose early adult/non-adult sepsis and the ability of PSP to predict mortality outcomes in paediatric sepsis. The combined results of sensitivity, specificity, positive likelihood ratios, negative likelihood ratios, area under the curve, diagnostic odds ratios and diagnostic scores indicated that PSP has good clinical value. No publication bias was found in any of the three meta-analyses. Conclusions Diagnosis and prognosis of sepsis by PSP has good accuracy and predictive value that warrants clinical promotion.